Periodontal disorder

This trial tests whether adding laser therapy to standard gum surgery improves treatment of advanced periodontitis. Adults with stage I to III periodontitis who still have deep pockets after initial non-surgical care will receive open flap debridement, a procedure that lifts the …

Researchers are testing whether a 2% melatonin gel placed directly into gum pockets can improve outcomes when added to standard non-surgical periodontal therapy. The trial enrolls 23 systemically healthy adults with Stage II Grade B periodontitis. Each participant receives standa…

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This Phase 3 trial tests whether a multi-component oral hygiene regimen, including specific mouthwashes and toothpaste, improves outcomes in adults with stage II periodontitis undergoing non-surgical periodontal treatment. Participants will use either an active regimen or a place…

This trial tests whether a gel made from a patient's own blood, called injectable platelet-rich fibrin (I-PRF), can improve the results of a minimally invasive non-surgical treatment for advanced gum disease. Researchers will compare three approaches: the standard deep-cleaning p…

This trial compares two surgical techniques used when a dental implant is placed immediately after removing a tooth in the upper front of the mouth. The goal is to see which technique better preserves the thin bone in front of the socket and the gum around the implant, which ofte…

This study looks at two different approaches to help pregnant people with gum disease get better dental care. Participants will receive free dental check-ups, cleanings, and supplies. The goal is to see which method reduces gum inflammation and improves oral health habits, and wh…

This trial asks whether GLP-1 receptor agonists, a class of drugs used for weight management, can improve gum health and boost the response to standard deep-cleaning treatment in people with obesity and periodontitis. Adults with both conditions will be split into two groups: tho…

This trial compares two types of clear retainers worn after braces to see if the way they are made affects gum health. One retainer is created from a digital scan of the teeth, while the other uses a traditional plaster mold. About 52 people who recently finished braces will wear…

This trial tests two methods for sealing the socket left after a tooth is removed, with the goal of preserving the gum and bone for a future replacement. One method uses a fixed, 3D-printed temporary tooth that supports the gum tissue, while the other uses a removable plastic gua…

This trial tests a new surgical technique that avoids cutting the gum tissue between teeth to repair deep bone defects caused by gum disease. The procedure uses a synthetic bone graft and a special gel to help the bone regenerate. The study includes 60 adults aged 35 to 65 with a…

This study investigates whether a daily probiotic lozenge containing Limosilactobacillus reuteri can reduce inflammation and improve gum health in adults with severe periodontal disease. Researchers will also analyze participants' oral and gut bacteria to identify who is most lik…

This study tests whether a new synthetic membrane, called Inox Nanoksa G-Plus, can help rebuild bone in the upper or lower jaw for adults who need dental implants but lack sufficient bone width or height. All participants receive the same surgery: the membrane is placed under the…

This trial tests a new toothpaste containing a Bio-Descaling Powder (BDP) to see if it can reduce hardened dental plaque (calculus) and gum inflammation. It includes 100 adults with gum disease or who are in a gum maintenance program. Participants brush with either the BDP toothp…

This study follows 100 adults who received short dental implants (7 or 8 mm) in the back part of the upper or lower jaw. Researchers want to see how well these implants hold up over 5 years by measuring bone loss, stability, and overall success. The goal is to determine if shorte…

This study looks at whether using a miswak stick—a natural teeth-cleaning twig—along with regular brushing can improve gum health in people with gingivitis. Researchers will measure markers of inflammation and oxidative stress in saliva and plaque. The goal is to see if this trad…

This study looks at how well 3D printed bone grafts work for supporting dental implants in people with gum disease or bone loss. Researchers will check if the implants stay stable and how much the graft shrinks over 1 to 6 years. About 100 healthy adults who already received this…

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study tests whether adding a daily synbiotic supplement (probiotics plus prebiotic) to standard non-surgical gum treatment improves gum health in smokers with advanced periodontitis. 92 smokers and non-smokers will be split into four groups, receiving either the supplement o…

This study tests whether adding a light-activated dye (photodynamic therapy) to standard deep cleaning improves gum disease more than cleaning alone. Thirty adults with periodontitis will have one side of their mouth treated with cleaning plus the dye/laser, and the other side wi…

This study tests a new gel made from peptides (protein fragments) to see if it can help regrow bone and tissue damaged by gum disease. Forty adults with advanced periodontitis will receive either the new peptide gel or a standard hyaluronic acid gel during surgery. Researchers wi…

This study compares two treatments for repairing bone damage from advanced gum disease. About 40 adults with deep gum pockets will receive either a combination of hyaluronic acid and polynucleotides (Regenfast) or enamel matrix proteins (Emdogain), both with a bone graft material…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

This small study tests a dental implant technique that leaves a piece of the natural tooth root (socket shield) and uses a mix of growth factors and bone graft material to support the implant. Seven adults needing a front tooth implant will be followed for 6 months to check bone …

This study tests a dental implant procedure for people with thin jawbone. Surgeons will place the implant and use the patient's own bone chips and special growth factor membranes to rebuild the bone around it. The study will check bone density and gum thickness before, right afte…

This study tests a new way to place dental implants by combining a technique called socket shield (which saves a piece of the tooth root) with concentrated growth factors made from the patient's own blood. The goal is to see if this helps preserve bone and improve implant stabili…

This study tests a new program that teaches pregnant women in Bangladesh how to care for their teeth and gums during routine prenatal visits. Over 95% of pregnant women in Bangladesh have gum disease, but oral health is not part of standard pregnancy care. The study will compare …

This trial tests whether adding a sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, to standard non-surgical gum treatment helps adults with periodontitis. 78 participants will receive one of three treatments and be checked after three months. The …

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for…

This study compares three oral hygiene routines in 90 adults aged 60+ who have gum disease and mild cognitive impairment. One group uses a special light device (Lumoral) plus a manual toothbrush, another uses a powered toothbrush (Oral-B iO), and a control group uses a manual too…

This study tests whether sending SMS reminders and advice to people with type 2 diabetes and gum disease can improve their blood sugar control over two years. 516 adults who recently completed gum disease treatment will be split into two groups: one gets standard follow-up, the o…

This study tests whether breath samples collected in special bags remain stable for up to 7 days, which could allow people with bad breath (halitosis) to provide samples from home instead of traveling to a clinic. Researchers will compare gas levels measured right away and after …

This study aims to validate an Italian version of a widely used questionnaire for screening periodontitis (gum disease). Researchers will also develop an enhanced version with additional questions and test how accurately it identifies people with the condition. About 495 adults a…

This study will check if a simple questionnaire can accurately identify gum disease in adults. About 291 participants in Saudi Arabia will fill out the questionnaire and then have a standard dental exam. The goal is to see how well the questionnaire matches the exam results, whic…

This study is developing a new, non-invasive saliva test that uses artificial intelligence to detect gum disease (periodontitis) early. Researchers will collect saliva from 200 adults—some with gum disease and some healthy—and analyze it with a special sensor. The goal is to see …

This study will enroll 2,000 adults to see if non-invasive methods like smartphone photos, dental X-rays, and questionnaires can accurately detect gum disease compared to a standard clinical exam. Researchers will use artificial intelligence to analyze the images and combine data…

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many r…

This study tests whether a simple, low-cost oral health program for pregnant women in rural Nepal can reduce the number of babies born too early, too small, or underweight. About 2,280 women will either receive daily antiseptic mouthwash and intensive oral hygiene education, or j…

Researchers are testing whether signaling molecules made by a patient's own fat-derived stem cells can help synthetic bone grafts build stronger jawbone. The trial enrolls 20 adults with severe upper-jaw bone loss who need sinus floor augmentation before dental implants. Each par…

This study tests a smoking cessation program delivered via telemedicine and wearable devices. About 102 adult smokers will either get the program with remote monitoring or standard in-person support. The goal is to see if the tech-based approach helps more people quit and stay sm…

This study looks at whether gum health is linked to thyroid function in pregnant women. Researchers will examine the gums and measure thyroid-related blood markers in 100 healthy pregnant women in their second trimester. The goal is to see if gum inflammation is associated with t…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study aims to find biological markers in saliva, mouth rinse, blood, or tissue that could help identify and predict the course of oral cancer, gum disease, and tooth decay. Researchers will collect health information and samples from 4,000 adults with these conditions and he…

This study looks at whether inflammation from gum disease during pregnancy can affect the womb environment and lead to early delivery. Researchers will measure markers of inflammation and oxidative stress in saliva and amniotic fluid from 80 healthy pregnant women. The goal is to…

This study looks at people who had treatment for peri-implantitis—an infection around dental implants—between 5 and 23 years ago. Researchers will check gum health, bone levels, and other signs to see which surgical or non-surgical approaches worked best over the long term. The g…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study looks at whether checking gum health 4 weeks after non-surgical treatment is better than waiting 8-10 weeks. Researchers will compare healing and pocket depth in 24 adults with advanced gum disease. The goal is to find the best time for follow-up to improve care.

This study looks at how mental health, especially stress, affects gum disease in people who grind their teeth. About 110 adults aged 30-50 with both teeth grinding and gum disease will answer mental health questions and get a dental check-up. The goal is to see if poor mental hea…

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This study will measure certain proteins and antioxidants in the fluid from gum pockets in 21 adults with gum disease. Researchers will take samples before and after a deep cleaning procedure (scaling and root planing) to see how these markers change during healing over 3 months.…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This observational study looks at whether eating lots of ultra-processed foods (like chips, soda, and packaged snacks) is linked to cavities and gum disease. Researchers will track the diets and oral health of 200 adults aged 18 to 65. No treatments or changes are given—just care…

This study looks at how much final-year dentistry and psychology students know about gum disease (periodontitis) and whether that knowledge is linked to their own gum health. About 60 students will fill out a questionnaire and get a dental check-up. The goal is to see if more kno…

This study will check the gum health of 100 people—half with multiple sclerosis (MS) and half without—by measuring gum pockets, plaque, and inflammation. Researchers will also test saliva for certain bacteria and viruses to see if they are linked to MS. The goal is to better unde…

This observational study will follow 94 transgender individuals for 12 months to see how gender-affirming hormone therapy affects their mood, stress, and heart health. Researchers will measure inflammation, blood vessel function, and other markers to understand potential cardiova…

This study will test three common techniques for removing a tiny amount of enamel between teeth to make room for clear aligners. Seventy-five adults will be randomly assigned to manual strips, motor-driven strips, or abrasive discs. The main goal is to see which method most close…

This study aims to find out if tiny plastic particles, called microplastics, are present in the deep gum pockets of people with severe gum disease (periodontitis). Researchers will collect plaque from 25 adults with advanced gum disease who have not yet started treatment. The goa…

This study looks at whether teeth that bear more chewing force are more likely to have severe gum disease. Researchers will measure bite patterns in 50 adults with natural teeth or fixed dental work. The goal is to understand the link between chewing loads and gum health, which c…

This study aims to understand how certain immune proteins, called NOD1 and NOD2, relate to gum disease. Researchers will collect saliva and blood samples from 75 people with healthy gums, gingivitis, or periodontitis. They will measure levels of these proteins and other markers t…

This study compares levels of oxidized LDL (a type of 'bad' cholesterol linked to heart disease) in the gum fluid of people with advanced gum disease versus those with healthy gums. Researchers aim to better understand the connection between gum inflammation and heart health. The…