Movement disorder

This trial is investigating whether ATH434, an experimental drug taken twice daily as a tablet, can help control multiple system atrophy (MSA), a rare and progressive brain disorder. The study enrolls people who have already completed a prior phase 2 trial of ATH434 and may benef…

Researchers are testing an experimental oral drug called ONO-2808 in adults with the Parkinsonian subtype of multiple system atrophy (MSA-P), a rare and progressive brain disorder. The phase 3 trial enrolls about 486 people in the early stages of the disease, within five years of…

This trial tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in people with spinocerebellar ataxia type 3, a genetic condition that affects coordination and balance. The stimulation targets a deep brain region involved i…

This early-stage trial tests whether an experimental antibody called α-Syn H21 is safe and might help people with multiple system atrophy (MSA), a rare and progressive brain disorder. The antibody is designed to latch onto and neutralize abnormal clumps of a protein called alpha-…

This phase 2 trial is investigating whether adding a ketogenic diet and/or high-dose intravenous vitamin C to standard chemoradiotherapy and immunotherapy can improve outcomes for patients with locally advanced rectal cancer that is mismatch repair proficient (pMMR/MSS). The stud…

This Phase 3 trial tests whether vatiquinone can slow the progression of Friedreich's ataxia, a rare genetic disorder that damages the nervous system and impairs movement. About 120 adults with moderate symptoms will take the drug for 24 months. Researchers will measure changes i…

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This trial tests whether deep brain stimulation (DBS) targeting the cerebellum is safe and feasible for people with spinocerebellar ataxia types 1 and 3, a group of inherited disorders that cause progressive problems with movement and coordination. The study will enroll 12 adults…

This early trial tests a gene therapy called ZR001 in people with moderately advanced Parkinson's disease. ZR001 is injected into a brain region involved in movement, and a very low dose of an existing drug is then used to activate the therapy. The goal is to see if this approach…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This early-stage study tests whether injecting special stem cells into the brain is safe for people with a rare, severe movement disorder called MSA-P. Only 3 participants will receive the treatment, and the main goal is to check for serious side effects within the first month. T…

This phase 3 trial tests whether short-course radiation followed by chemotherapy and an immunotherapy drug (serplulimab) works better than standard long-course chemoradiation for high-risk locally advanced rectal cancer. 612 patients will be randomly assigned to one of the two tr…

This Phase 2 trial tests whether umbilical cord stem cells can safely improve movement and coordination in people with spinocerebellar ataxia (types 1, 2, 3, and 6). Forty-five participants will receive the cells through an IV and a spinal injection. The main goal is to see if sy…

This early-stage trial tests whether stem cells and their exosomes (tiny particles that help cells communicate) can safely improve movement in people with spinocerebellar ataxia, a condition that affects coordination and balance. Ninety participants will receive the treatment thr…

This study tests whether a person's own stem cells, processed and given by IV, can safely help with multiple system atrophy (MSA) — a rare, worsening brain disease that affects movement and automatic body functions like blood pressure. Fifty adults aged 35 to 65 will receive eith…

This early-stage study tests whether stem cells from umbilical cords are safe for people with Parkinson's disease. About 20 adults will receive either the cells or a placebo, and researchers will monitor side effects and any changes in movement. The goal is to see if this approac…

This study tests whether adding scalp acupuncture to repetitive transcranial magnetic stimulation (rTMS) improves arm movement in stroke survivors. Researchers will compare two groups: one getting rTMS plus standard rehab, and another getting rTMS plus scalp acupuncture and stand…

This study tests a new drug called NS101 in 15 people with semantic variant primary progressive aphasia (svPPA), a rare type of frontotemporal dementia that affects language and memory. The drug is an antibody designed to help repair connections between brain cells. The main goal…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study will test a new intelligent diagnostic system for orthostatic hypotension (a sudden drop in blood pressure when standing up). The system continuously monitors blood pressure, brain blood flow, and heart signals to classify the condition more precisely. Researchers plan…

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

Researchers at Lund University are testing a new way to deliver deep brain stimulation using a cluster of very thin, flexible microelectrodes. The study includes up to 12 adults with Parkinson's disease or essential tremor who are already scheduled for standard deep brain stimula…

Progressive supranuclear palsy (PSP) causes problems with movement, thinking, and behavior, including impulsivity that can lead to falls. Researchers are testing a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) aimed at the right in…

This study tests a botulinum toxin called DaxibotulinumtoxinA (DAXI) for adults with blepharospasm, a condition causing uncontrollable blinking or eye muscle spasms. Twenty participants will receive up to three injection cycles over 12 months. The goal is to measure how long symp…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study tests whether using brain images to program deep brain stimulation (DBS) devices works better than the usual method for reducing hand tremors in people with essential tremor. Twenty adults who already have DBS electrodes in their brain will try both programming approac…

This study tests a continuous passive motion device that gently moves the knee for young children with arthrogryposis after they have knee surgery. The goal is to see if the device improves knee range of motion. Five children aged 3 to 7 who recently had knee surgery will take pa…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This phase 1 trial tests whether low-energy focused ultrasound can safely and temporarily reduce tics in people with Tourette syndrome. Twenty participants aged 16 and older receive ultrasound to deep brain regions or the motor cortex, or a sham treatment, across four sessions. T…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve voice quality in people with laryngeal dystonia, a condition that causes involuntary muscle spasms in the voice box. Twenty adults with the c…

This study tests a new device that uses muscle signals from the face and neck to recognize silent speech and turn it into voice. It is for adults who have lost their voice due to laryngectomy or severe voice problems. The goal is to see if the device can accurately identify words…

This study tests whether the sleep medication lemborexant can improve both sleep and motor symptoms in people with Parkinson's disease. Forty-four participants will take either lemborexant or a placebo nightly for 28 days. Researchers will measure changes in sleep quality and mov…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation can improve tremor and walking difficulties in people with Parkinson's disease. Fifty participants will be randomly assigned to receive either real or sham stimulation dai…

This study tests a 16-week home-based exercise program for people with Parkinson's disease. Fifty participants will either do aerobic and resistance training or just stretching. The goal is to see if the program increases daily physical activity, improves thinking, and enhances q…

This study tests if a new dynamic compression device, used with compression stockings, works as well as current treatments for reducing leg swelling in people with lymphedema. About 98 adults with stage II or III lymphedema will use either the new device or standard wraps and pum…

This study compares a new dynamic compression device to traditional bandages for reducing leg swelling in people with lymphedema. Over 5 days of intensive treatment, 110 participants will wear either the device or standard bandages. The goal is to see which method reduces excess …

This study will test if acupuncture can reduce tics (uncontrolled movements or sounds) in children aged 5 to 18. Researchers will also use special brain scans to see how acupuncture might affect the brain. The goal is to find a safe, non-drug treatment for tic disorders.

This study compares two ways of giving Botox injections to treat voice tremor, a condition that causes a shaky voice. About 30 adults with essential voice tremor will receive either a standard injection guided by muscle signals or a newer injection into a different part of the vo…

This small pilot study will test whether a non-invasive electrical stimulation technique called tTIS can reduce tremors in people with essential tremor. Six adults who are already candidates for a standard treatment (focused ultrasound) will receive tTIS to a deep brain area invo…

This pilot study tests a 4-week program based on acceptance and commitment therapy (ACT) for women who have experienced a miscarriage, stillbirth, or newborn death within the past year. The program includes six sessions plus a booster, combining in-person and video meetings. Rese…

This early study tests whether a long-acting form of sodium oxybate (Lumryz) can improve voice symptoms in 8 adults with spasmodic dysphonia or voice tremor. Participants will take the drug and have their voice and brain activity measured. The goal is to see if the drug works and…

This study tests a daily oral medication called SCI-110, made from cannabinoids, to see if it can safely reduce tics in adults with Tourette syndrome. About 164 adults aged 18 to 65 with moderate to severe tics will receive either the drug or a placebo, then switch after 12 weeks…

This study tests whether butylphthalide, a drug used for stroke, can improve symptoms of Multiple System Atrophy (MSA), a rare and serious brain disorder. About 150 adults with MSA will take either the drug or a placebo three times a day for six months. Researchers will track sym…

This study tests whether a precise beam of ultrasound directed at a small part of the brain (the dentate nucleus) can reduce tremor. First, 30 healthy volunteers will have their hand tremor measured during ultrasound to find the best settings. Then, 30 people with essential tremo…

This study tests if low-intensity focused ultrasound (LIFU) can safely reduce tremors and improve quality of life in people with essential tremor. Twenty adults with hard-to-treat tremors will receive both real LIFU and a fake (sham) treatment in separate sessions to compare effe…

This study looks at whether doing aerobic exercise at home, with or without the drug omaveloxolone, can safely improve fatigue and heart-lung fitness in people with Friedreich's ataxia. About 30 adults with the condition will take part. The goal is to see if the combination helps…

This study tests whether a special type of speech training using five musical tones can help people with aphasia (trouble speaking) after a stroke. Researchers will enroll 120 adults who had a stroke and have non-fluent aphasia. Participants will receive either five-tone therapy …

This study compares voice therapy delivered in-person versus via telehealth for adults aged 55 and older with age-related voice problems. Thirty participants will receive four sessions of PhoRTE® voice exercises either face-to-face or through video calls. Researchers will measure…

This study looks at whether new ways of programming deep brain stimulation (DBS) can improve tremor control in adults with essential tremor who stopped responding to standard DBS. Five participants will try six different stimulation settings and use one at home for three months. …

This pilot study tests whether shining red and near-infrared light on the scalp (photobiomodulation) can temporarily improve balance and cognitive function in 20 adults with ataxia. Participants will receive either active light or a sham device in a randomized, placebo-controlled…

This study tests if a long-lasting numbing drug (liposomal bupivacaine) injected into the scalp before surgery can reduce pain after a specific type of brain surgery called microvascular decompression. About 100 adults having this surgery will be randomly assigned to receive eith…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve movement and balance in children with cerebellar ataxia, a condition that causes coordination problems. Twenty children aged 4 to 18 will receive either real or sham (fake) rTMS to see if …

Researchers at the University of California, San Francisco are studying how well a calibrated touch device measures sensation in the larynx and throat. The study includes adults with larynx or throat disorders, including those whose condition followed radiation or other cancer tr…

Researchers are studying whether navigational memory fades before other spatial memory in people with Parkinson's disease and related conditions. The pilot includes 80 participants: those with mild or advanced Parkinson's, those with parkinsonism, and healthy volunteers. Particip…

This observational study looks at adults aged 18 to 85 with neurological conditions like stroke, Parkinson's disease, or spinal cord injury who use robotic or virtual reality tools in their rehabilitation. Researchers want to see if hope and the quality of the patient-provider re…

This study is testing whether wearable sensors can reliably measure tremor and arm movement in people with Parkinson's disease or Essential Tremor. Participants will wear the sensors during a clinic visit and possibly at home for up to three weeks. The goal is to see if these dev…

This observational study tests whether wearable sensors and digital health tools can reliably measure falls, movement, speech, and thinking skills in people with progressive supranuclear palsy, Parkinson's disease, or multiple system atrophy. Participants wear a pendant sensor an…

This study is testing whether a new digital tool—using AI-powered video games and a single camera—can accurately measure movement problems in people with Friedreich ataxia, a rare inherited condition that affects balance and coordination. Participants play short movement-based co…

This study investigates how a drug called Cobenfy KarXT, which affects the brain's cholinergic (acetylcholine) system, alters brain activity during memory and thinking tasks. About 30 people with essential tremor or epilepsy who are already scheduled for deep brain stimulation (D…

This study will check if two common brain monitors used during anesthesia (BIS and Sedline) give accurate readings in children with severe seizure disorders. Researchers will compare these monitors to a standard EEG in 40 children under 16. The goal is to make anesthesia safer fo…

This study follows babies and young children (up to age 5) who have a genetic diagnosis of ataxia telangiectasia (A-T), a rare disease that affects movement and immunity. Researchers use brain and lung scans, blood tests, and movement analysis to spot early signs of disease progr…

This study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…

This study from Stanford University will look at how people react when they learn their Lewy Body Disease biomarker test results. Researchers will interview and survey 40 participants, both with and without symptoms, to measure distress and other responses over time. The goal is …

This pilot study will test whether using ultrasound during common office procedures for voice and swallowing problems is helpful and practical. Researchers will enroll 200 adults with conditions like chronic cough, vocal cord issues, or swallowing difficulties. They will measure …

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This study will test if wearable sensors can effectively monitor symptoms and daily function in people with frontotemporal dementia (FTD). Sixty adults with FTD will wear pendant and wrist sensors for two weeks at a time, every six months over two years. The goal is to develop di…

This study tests whether wearable sensors and computerized voice and thinking tests can reliably track symptoms in people with frontotemporal dementia (FTD). Twenty participants will wear sensors and complete assessments at home over 12 months. The goal is to develop digital biom…

This study will test a wearable device called Syde® in 30 people with progressive supranuclear palsy (PSP-R). The device tracks movement and activity during daily life. Researchers want to see if patients find it easy to use and if the data matches standard clinic tests. The goal…

This study will see if an AI chatbot app is practical and acceptable for family caregivers of people with traumatic brain injury, dementia, or Huntington disease. About 60 caregivers will use the app for 8 weeks, focusing on physical and mental health. They will complete surveys …

This early-stage study will give 8 healthy men a single radioactive dose of LPM3770164, a drug being developed for Huntington disease. Researchers will measure how much of the drug is recovered in urine and stool, and identify its breakdown products. The goal is to understand how…

This study looks at how Huntington's disease impacts autobiographical memory—the ability to recall personal experiences and imagine future events. Researchers will use eye-tracking and neuropsychological tests in 80 participants (patients and healthy controls) to find markers of …

This study will look at 800 patients who had aortic surgery to understand why some develop dangerous blood clots inside the repaired artery. Researchers want to find out how common these clots are, what puts patients at risk, and how they affect recovery. The goal is to improve c…

This study will look at sleep in 34 children with Tourette syndrome, comparing them to children without the condition. Researchers will use a special tic index, a watch-like movement tracker, and overnight sleep recordings to see how tics affect sleep quality. The goal is to bett…

This study checks if a tool called the Hypertonia Assessment Tool (HAT) can correctly identify different types of muscle tightness in adults who have had a stroke. The tool was already tested in children with cerebral palsy, but not in adults after stroke. Researchers will test 6…

This study aims to better understand pain in people with a rare genetic form of arthrogryposis (stiff joints) caused by a PIEZO2 mutation. About 12 participants aged 10 and older will track their pain daily for two weeks using simple questionnaires and body charts. No drugs or tr…

This study aims to see if wearable sensors and digital health tools can accurately track symptoms of Huntington's disease over 12 months. About 75 adults with and without Huntington's will wear sensors on their wrist, ankle, and pendant to measure daily activity, and complete spe…