Cervical dystonia

This study explores whether gentle vibrations on neck muscles can help people with cervical dystonia hold their head straighter. Fifty adults with the condition will receive different vibration intensities during a single three-hour lab visit. Researchers will measure head postur…

This Phase 2 trial tests whether adding valbenazine (a daily pill) to standard botox injections can further reduce neck muscle spasms and pain in people with cervical dystonia. About 20 adults who still have symptoms despite botox will receive either valbenazine or a placebo for …

This study tests whether taking zinc supplements can help Botox injections last longer for people with cervical dystonia, a condition that causes painful neck muscle spasms. About 25 adults will take either zinc or a placebo daily for 3 months, then switch to the other for anothe…

This study tests a new drug, IPN10200, for adults with cervical dystonia—a condition causing painful neck muscle spasms. Current treatments last about 3 months, but IPN10200 is designed to work longer. Around 132 participants will receive either the drug or a placebo injection, a…

This study is testing a device called ViBandz, which uses small vibrating motors strapped to the body to provide vibration therapy. Researchers want to see if it is easy and comfortable for children with neurological conditions to use at home. The study will involve 30 children a…

This study compares two ways of giving Botox injections for cervical dystonia, a condition that causes painful neck muscle spasms. One method uses ultrasound to see the muscles, the other relies on touch and body landmarks. About 100 adults will receive both types of injections a…

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

This study tests whether a personalized exercise program can improve pain, disability, and quality of life in people with cervical dystonia who already receive botulinum toxin injections. Thirty-four participants will be split into two groups: one gets tailored stretching and str…

This study aims to understand the link between genes and symptoms in people with inherited movement disorders. Researchers will study up to 2,500 participants, including patients and their family members, to identify new disease-causing genes and improve diagnosis. The goal is to…

This natural history study is collecting information from up to 4,000 people with movement disorders (like Parkinson's disease or tremor) and their family members. Participants undergo exams, blood tests, and imaging, but receive no new treatments. The goal is to gather data that…

This study aims to find the genetic causes of movement disorders and dementias by analyzing DNA from up to 12,000 participants, including patients and their family members. Researchers will collect blood or saliva samples and look for gene mutations linked to these conditions. Th…

This study is gathering medical information and samples from up to 5,000 people with neurosurgical conditions like brain tumors, epilepsy, and Parkinson's disease. Participants receive standard care while their data is collected for future research. No new treatments are being te…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study uses brain scans and genetic tests to explore why different forms of focal dystonia develop. Researchers will compare brain activity and structure in people with dystonia, their unaffected relatives, and healthy volunteers. The goal is to identify unique brain markers …

This study aims to translate the Hypertonia Assessment Tool (HAT) into Turkish and check if it works correctly. The HAT helps doctors identify different types of increased muscle tone in children with motor disorders. Researchers will test the tool on 70 children under 18 who hav…

This study looks at how deep brain stimulation (DBS) — a treatment already used for movement disorders — affects voice and speech in people with laryngeal dystonia or voice tremor. Researchers will record brain signals during surgery and measure voice changes afterward. The goal …