Cervical dystonia
MONDO:0000481Cervical dystonia is a neurological condition characterized by excessive pulling of the muscles of the neck and shoulder resulting in abnormal movements of the head (dystonia).Most commonly, the head turns to one side or the other.Tilting sideways, or to the back or front may also occur.The turning or tilting movements may be accompanied by shaking movement (tremor) and/or soreness of the muscles of the neck and shoulders.Cervical dystonia can occur at any age, but most cases occur in middle age. It often begins slowly and usually reaches a plateau over a few months or years. The cause of cervical dystonia is often unknown. In some cases there is a family history. Several genes have been associated with cervical dystonia, including GNAL, THAP1, CIZ1, and ANO3. Other cases may be linked to an underlying disease (e.g. Parkinson disease), neck trauma, or certain medications. Treatment may include local injections of botulinum toxin, pain medications, benzodiazepines (anti-anxiety medications), anticholinergics,physical therapy, or surgery.
Also known as: spasmodic torticollis
29 clinical trials for this condition and its sub-types.
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Brain zaps + pill may ease twisted neck disorder
Symptom relief ENROLLING_BY_INVITATIONThis study tests whether a personalized form of brain stimulation (TMS) combined with a medication can improve neck muscle control in people with cervical dystonia. Fifty adults with the condition will receive either real or sham TMS in a single day, along with the drug trihexyph…
Phase: PHASE2 • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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New pill could ease neck dystonia symptoms
Symptom relief TerminatedThis study tests an experimental oral medication, MTR-601, for people with cervical dystonia, a condition causing painful neck muscle spasms and abnormal head posture. About 80 adults will receive either the drug or a placebo for 8 weeks to see if it safely reduces symptoms. The …
Phase: PHASE2 • Sponsor: Motric Bio • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC