Hearing loss disorder

This study is testing a device called the BONEBRIDGE, a bone conduction implant that helps people with certain types of hearing loss hear better. The implant is placed under the skin behind the ear during surgery and works by sending sound vibrations through the skull bone direct…

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This study tests a new totally implantable cochlear implant system (TICI G2) that has a microphone under the skin, so you can hear without any external devices. Researchers will enroll 18 adults with sensorineural hearing loss to see how well the internal microphone works over ti…

This pilot study aimed to test whether a mixture of dexamethasone, hyaluronic acid, and a green dye could be safely injected into the ear to treat certain types of hearing loss that don't improve with standard treatments. The plan was to enroll 26 adults with sudden hearing loss,…

This study tests a new type of cochlear implant that is completely hidden under the skin, with no external processor. It is designed for adults with severe hearing loss who do not get enough benefit from hearing aids. The implant picks up sound through a microphone under the skin…

This study follows 100 people with vestibular schwannoma (a non-cancerous ear tumor) who previously received a gene therapy called AAVAnc80-antiVEGF. Researchers will monitor for late side effects and measure tumor size changes over time using MRI scans. The goal is to understand…

This study follows 30 people who previously received a gene therapy (AAVAnc80-hOTOF) for hearing loss caused by otoferlin gene mutations. Researchers will monitor safety over the long term, checking for late side effects, and measure hearing improvements using brain response test…

This study tests a fully implanted cochlear implant called Acclaim CI in 56 adults with severe to profound hearing loss. The goal is to see if it helps them hear words better than before and to check for any medical problems. Participants get the implant and are followed for up t…

This early-phase study is testing whether stem cell therapies and experimental drugs can help repair inner ear damage in people with hearing loss or tinnitus. Researchers will monitor 120 adults over time using hearing tests and symptom surveys. The goal is to see if these regene…

This study compares cochlear implants to hearing aids in 80 children aged 4 to 14 with hearing loss in one ear. Researchers measure how well kids understand speech and hear in noise before and after getting an implant. The goal is to see if the implant provides better hearing tha…

This study is testing a new device called a multichannel vestibular implant for people who have lost most or all of their balance function due to inner ear damage. The implant electrically stimulates the balance nerve to help improve stability and vision during movement. Up to 30…

This study tests whether a personalized, data-driven hearing rehabilitation program can improve hearing, thinking, and quality of life in older adults with mild to moderate hearing loss. Two hundred first-time hearing aid users will be randomly assigned to either the new personal…

This trial is testing a combined cochlear and vestibular implant (CVI) in 13 people who have lost both hearing and balance function due to bilateral vestibulopathy. The implant stimulates the nerves for hearing and balance to see if it can improve stability, vision during movemen…

This study tests a single injection of a new drug called AC102 into the ear, comparing it to standard steroid pills for sudden hearing loss. About 210 adults with hearing loss in one ear will take part. The goal is to see if the injection improves hearing better than steroids, wi…

This study was designed to see if a small device placed in the inner ear during acoustic neuroma surgery can keep the cochlea from filling with scar tissue. If successful, patients who lose hearing from the surgery could still get a cochlear implant later. The study was withdrawn…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests an advanced ultrasound otoscope, a device that uses sound waves to look inside the ear and detect fluid behind the eardrum. Researchers will compare its readings to the surgeon's findings during ear tube surgery in 300 children up to 12 years old. The goal is to …

This study aimed to test whether an oral drug called SPI-1005 (ebselen) could prevent temporary hearing loss caused by loud noise. Researchers planned to enroll adults aged 18-50 with a history of noise exposure and give them the drug or a placebo for 7 days, then measure hearing…

This study was designed to test whether an oral drug called SPI-1005 could prevent hearing loss and ringing in the ears caused by platinum-based chemotherapy. It was planned for adults with advanced lung or head and neck cancer. The study was withdrawn before enrolling any partic…

This study tests whether sodium thiosulfate can prevent hearing loss in children and young adults (ages 1 month to 39 years) who are receiving cisplatin chemotherapy for relapsed or hard-to-treat liver tumors and other embryonal cancers. Some participants also get vorinostat. The…

This study looks at whether auto-captioning glasses are easy and helpful for adults with NF2-related schwannomatosis who have hearing loss. Eighteen participants will use the glasses for 12 weeks and report their experience through surveys and interviews. The goal is to see if th…

This study looks at whether cochlear implants are safe and effective for adults with severe hearing loss in both ears who currently don't meet standard implant criteria. Fifty participants will receive an implant and be followed for 6 months to measure improvements in word recogn…

This study tests whether adding a superficial cervical plexus block to standard care reduces opioid use and pain in children aged 3 months to 18 years undergoing ear surgery (cochlear implant or tympanomastoidectomy). Half the children get the block plus standard care, the other …

This study tests new speech-enhancement software in cochlear implants to help adults with hearing loss understand speech better in noisy places. About 150 adult cochlear implant users will compare the new algorithms to the standard ones. The goal is to see if the new software imp…

This study tests whether motivational interviewing, a counseling style that encourages behavior change, can help new hearing aid users wear their devices more often and feel better about their hearing. Researchers will enroll 180 adults who are new to hearing aids and compare tho…

This study tests a mobile app called iPREPARED that helps patients and their caregivers prepare for a hospital stay. The app provides videos and tips to prevent or reduce delirium, a sudden confused state common in older adults. Researchers want to see if the app is easy to use a…

This study tests whether an 8-week auditory-cognitive training program can improve speech recognition and cognitive function in older adults (60+) who have had a cochlear implant for 3 months to 3 years. Participants will do computer-based listening and thinking exercises at home…

This study tests different automatic sound management features on MED-EL cochlear implants to see which helps adults hear speech best in background noise. About 20 experienced cochlear implant users will listen to sentences in noise and report what they hear. The goal is to find …

This study tests whether adjusting the frequency settings of a cochlear implant based on a person's ear anatomy can improve hearing and quality of life. Fifty new cochlear implant users with some hearing in their other ear will try two different settings and complete hearing test…

This study tests a hearing care program for older Korean Americans (age 60+) who have hearing loss but do not use hearing aids. The program includes a low-cost sound amplifier and communication training, delivered in the community. Researchers will compare participants who get th…

This study tests experimental sound coding strategies that may improve hearing for adult cochlear implant users. About 120 participants will compare the new strategies to their current settings, focusing on understanding speech in noisy environments. The goal is to find ways to m…

This study tests a new cochlear implant that slowly releases a drug called dexamethasone to reduce swelling and tissue damage after surgery. The goal is to see if this helps the implant work better and improve hearing in adults with severe hearing loss. About 56 adults will recei…

This study tests a new cochlear implant that slowly releases dexamethasone, a drug that reduces inflammation after surgery. The goal is to see if it works better than a standard implant for adults with severe hearing loss. About 48 adults will be randomly assigned to get either t…

This study tests an 8-week exercise program designed for deaf adults aged 60 and older. The classes are taught in American Sign Language and meet twice a week. Researchers will measure balance, leg strength, walking speed, and confidence to see if the program helps reduce fall ri…

This study is testing whether hearing aids alone or hearing aids with a tinnitus masker can improve hearing and reduce tinnitus symptoms in adults with hearing loss and tinnitus. One hundred participants will wear hearing aids for 6 months, with the masker turned on after 3 month…

This study tests whether using special communication technology (AAC) alongside speech therapy helps children who are deaf or hard of hearing develop language faster. Half of the 154 children will use AAC tools, while the other half continue their usual therapy. Researchers will …

This study looks at whether traditional exercises like Tai Chi and Baduanjin can help people with hearing loss feel better physically and mentally. About 90 adults with severe hearing loss will be split into three groups: one doing Tai Chi, one doing Baduanjin, and one doing regu…

This study aimed to compare two over-the-counter hearing aids—the Lexie B3 Pro and a competitor—in adults with mild to moderate hearing loss. Participants would have tested each device and reported their experiences. However, the trial was withdrawn before any participants were e…

This study aims to see if a self-fitting over-the-counter (OTC) hearing aid works as well as a professionally fitted prescription device for adults with mild-moderate hearing loss. The research involves three phases: validating a hearing test, checking user experience, and a rand…

This early-phase study tests whether donepezil, a drug used for Alzheimer's, can improve speech recognition in adults who already use a cochlear implant. Researchers think the drug may help the brain adapt to the implant's signals. Fifty participants will receive either donepezil…

This study aims to find the genes that cause inherited hearing loss by analyzing DNA from 24,000 people in large Pakistani families. Researchers will compare affected and unaffected family members to identify new deafness genes. The goal is to improve genetic testing and counseli…

This study follows 88 deaf or hard-of-hearing children who, as toddlers, were randomly assigned to receive a 6-month parent coaching program or standard care. Researchers want to see if the early coaching leads to better language, reading, and social skills when the children reac…

This study tests a new type of cochlear implant that uses light instead of electricity to stimulate the hearing nerve. Researchers hope light can target smaller nerve groups, leading to clearer sound. The trial involves 30 adults who are already having ear surgery for tumor remov…

This study looks at whether hearing aids programmed to match a person's unique listening style can improve speech understanding in noisy environments. Thirty adults with sensorineural hearing loss will attend a 2-hour lab visit, where they will listen to sentences in noise with b…

This study follows 100 people aged 60-85 with mild memory or movement problems to see if losing smell, hearing, or balance speeds up cognitive decline. Researchers will test these senses and track thinking skills and quality of life for 5 years. The goal is to understand which se…

This study looks at whether people with a MED-EL cochlear implant can use a smartphone app to check their hearing from home instead of going to the clinic. About 50 participants will try the remote check and report how well it works, how much time and money it saves, and how easy…

This study aimed to understand how exposure to HIV and antiretroviral therapy in the womb might affect hearing in children who are HIV-free. Researchers planned to test hearing abilities in healthy infants born full-term. However, the study was withdrawn before enrolling any part…

This study looks at whether a special parent training program can help families with deaf or hard of hearing children aged 3 to 6. The program teaches positive parenting strategies to prevent behavior problems. About 295 parents will take part, and researchers will measure change…

This study, run by Apple and the University of Michigan, tracks headphone and environmental sound exposure in 300,000 US adults using iPhones and Apple Watches. Participants answer surveys and take hearing tests through the Research app. The goal is to understand how everyday sou…

This study tests a new technique that lets a cochlear implant stimulate the entire cochlea without needing a longer electrode. The goal is to see if this improves speech understanding and sound quality for people with hearing loss. About 40 adults who already qualify for a cochle…

This study tests whether a special technology tool can help deaf or hard-of-hearing children ages 3-10 improve their language skills. About 114 children will be randomly assigned to use the tool or continue their usual therapy. Researchers will measure changes in vocabulary, sent…

This study follows 44 people with a rare genetic form of Usher syndrome caused by PCDH15 mutations. Over 48 months, researchers measure how their vision changes using eye exams and imaging. The goal is to identify the best ways to track disease progression, which will help design…

This study looks at how stimulating a nerve in the ear affects pupil size during cochlear implant surgery. Researchers will measure pupil dilation in 30 adults to learn more about the vagus nerve's role in hearing. The goal is to gather knowledge, not to treat hearing loss direct…

This study looks at whether managing cochlear implant care remotely (via phone or app) works as well as going to the clinic. About 148 adults with hearing loss will be followed for a year after their implant is activated. The goal is to see if remote care saves time and money whi…

This study tests a hearing program for older adults who don't have easy access to hearing care. During a primary care visit, participants are screened for hearing loss and then randomly assigned to either get counseling on affordable listening devices or be referred to standard a…

This study planned to test whether playing specially designed video games at home could improve the ability of older adults with high-frequency hearing loss to understand speech in noisy environments. Participants would have played either an immersive audiomotor game or an audito…

This study looks at how deaf children in kindergarten through 3rd grade develop sign language skills. Eight children from a school for the deaf will receive special sign instruction and have their language progress tracked daily. The goal is to understand how teaching methods aff…

This study looks at whether a special training program for teachers can help deaf children learn sign language better. About 150 teachers and their deaf students (ages 4-12) are taking part. Teachers are split into two groups: one gets the new training, the other continues as usu…

This study follows 39 adults with severe hearing loss who are getting a cochlear implant. Researchers will test their hearing and balance at several points over two years, using both objective tests and patient questionnaires. The goal is to better understand how the implant affe…