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Turmeric compound tested against the ringing in millions of ears

NCT ID NCT04800107

Symptom relief Sponsor: Henry Ford Health System Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers are testing whether a highly absorbable form of curcumin, the main compound in turmeric, can reduce the bothersome ringing or buzzing of subjective tinnitus. The study enrolls adults whose tinnitus comes from sensorineural hearing loss, confirmed by a routine hearing test. Participants take either the curcumin supplement or a placebo capsule, and researchers measure changes in tinnitus severity using two standard questionnaires, the Tinnitus Functional Index and the Tinnitus Handicap Inventory.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A highly absorbable form of curcumin, the yellow compound in turmeric, combined with boswellia
What this could lead to
If it works, this could offer a low-cost, plant-based option to help quiet ringing in the ears for people with hearing-related tinnitus.
What could go wrong
Curcumin is poorly absorbed and many supplements fail to show real benefit. This is an early, single-center study, so any positive signal may not hold up in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Jan 2021

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults with subjective tinnitus due to sensorineural hearing loss as determined by routine audiogram. Exclusion Criteria: * Adults with subjective tinnitus due to another cause * Sensitivity or allergy to test compounds * Use of other off-label medications, substances, treatments specifically for tinnitus mitigation (e.g., anti-depressant/anxiety medications, GABA-inhibitors, psychiatric-based interventions/counseling) * Pregnancy * Patients taking anticoagulants to minimize risk of drug-drug interactions.

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Conditions

The condition(s) this trial relates to.

sensorineural hearing loss disorder tinnitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tinnitus, subjective

Contacts and locations

Locations

  • Michigan Ear Institute

    Novi, Michigan, 48374, United States

  • Michigan Ear Institute

    Royal Oak, Michigan, 48073, United States

  • Michigan Ear Institute

    Farmington Hills, Michigan, 48334, United States

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