Can a gene therapy restore natural hearing after cochlear implants?
NCT ID NCT07752888
First seen Aug 07, 2026 · Last updated Aug 13, 2026 · Updated 2 times
Summary
This trial tests an experimental gene therapy called EA0010 in children aged 1 to 17 with hearing loss caused by mutations in the OTOF gene, who already have cochlear implants. The therapy is injected into one ear and aims to deliver a working copy of the OTOF gene to inner ear cells. The study will check whether the treatment is safe and whether it can improve hearing beyond what the implant provides.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- EA0010, an investigational gene therapy using two AAV vectors carrying the OTOF gene, injected into the inner ear
- What this could lead to
- If successful, this could enable children with OTOF-related hearing loss to hear without relying on cochlear implants, potentially restoring more natural hearing.
- What could go wrong
- This is an early, very small trial (one participant), so results may not generalize. Risks include immune reactions, inflammation, or the therapy not improving hearing.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Chilling the ear canal during cochlear implant surgery may protect residual hearing
- Real-World data sheds light on Long-Term cochlear implant performance
- New software could give surgeons a Real-Time view inside the ear during cochlear implant surgery
- One-Time injection aims to restore hearing in children born deaf
- Could same-day activation of cochlear implants speed up hearing recovery?
- Can tweaking cochlear implant settings help people hear better in noise?