Digestive system infectious disorder

This study looks at whether a medicine called peginterferon alfa, alone or with other antivirals, can clear the hepatitis B surface antigen from the blood. A total of 10,000 adults aged 18-65 who have used interferon before and still have low antigen levels will take the treatmen…

This study tests a new vaccine (IP-QSV) designed to protect against four types of Shigella bacteria, which cause severe diarrhea. The trial will include 370 healthy adults, children, and infants in Mali. Researchers will check if the vaccine is safe and triggers a strong immune r…

This early-stage trial will test an experimental vaccine against hepatitis C (HCV) in 27 healthy adults. The main goal is to see if the vaccine is safe and to measure the immune response it triggers. Participants will receive three shots over 24 weeks and be closely monitored for…

This early-stage study tests a new oral cholera vaccine called DuoChol in 60 healthy adults aged 18 to 45 in Sweden. Participants will receive two doses of either DuoChol or an existing vaccine (Dukoral) to compare safety and immune response. The goal is to gather initial data to…

This study follows up on African children who received an experimental Shigella vaccine in earlier studies. Researchers will take blood samples 1, 2, and 3 years after the last vaccine dose to see how long the immune protection lasts. No new vaccines are given in this study. The …

This study tests a drug called foscenvivint in people with liver cirrhosis caused by HIV and hepatitis C co-infection who also have hemophilia. Participants receive the drug once a week for 24 weeks. Researchers will check if the drug improves liver function and is safe to use.

This early-stage trial tests an injection called TVAX-028 in adults with chronic hepatitis B. The study checks if the drug is safe and how the body processes it. Participants receive either TVAX-028 with an adjuvant or the adjuvant alone, at different dose levels. The goal is to …

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This study tests whether a combined approach—offering HIV PrEP (pills or injections) and STI prevention (doxycycline after sex) along with smartphone tools—helps young men at high risk stay protected. About 400 men aged 18-29 who have sex with men will be followed for a year to s…

This phase 2 trial tests an experimental drug called AHB-137 in 70 adults with chronic hepatitis B who are already on antiviral pills. The drug is given as a shot under the skin. The goal is to see if it can lower the virus to undetectable levels and allow some people to stop the…

This phase 2 trial tests an injection called AHB-137 in adults with chronic hepatitis B who have not yet received treatment. The study compares AHB-137 to a placebo to see if it can lower the amount of hepatitis B virus in the blood and reduce a key marker of infection (HBsAg). P…

This Phase 2 trial tests an injection called AHB-171 in 138 people with chronic hepatitis B. The goal is to see if it can lower hepatitis B surface antigen and viral DNA to very low levels, potentially leading to a functional cure. Participants include those who have never been t…

This early-phase study tests a new injectable drug called AHB-171 in 144 adults with chronic hepatitis B. The main goals are to check the drug's safety and how the body processes it. Some participants will also take standard oral antivirals. The study is not yet recruiting.

This study tests an experimental injection called HRS-5635 in adults with chronic hepatitis B whose virus is already controlled by daily pills. The goal is to see if the injection can help the body clear the virus so patients can safely stop all hepatitis B medications. About 540…

This early-stage study tests a single injection of AHB-137 in 32 people with chronic hepatitis B, some with mild to moderate liver dysfunction and some with normal liver function. Researchers will measure how the drug moves through the body and check for safety issues. The goal i…

This early-stage trial is testing a new drug called ACT500 in 24 people who have both fatty liver disease and chronic hepatitis B. The main goal is to check the drug's safety and how the body processes it at different doses. Participants will take ACT500 or a placebo daily, and r…

This phase 3 trial tests a new drug called GST-HG141 (Nairecovir) combined with standard antivirals in 576 adults with chronic hepatitis B. Participants have already completed 48 weeks of treatment in an earlier study. The goal is to see if the combination is safe and helps keep …

This study tests whether a one-visit, point-of-care test and treat approach helps more people with HIV, hepatitis B, or hepatitis C complete hepatitis C treatment within 24 weeks compared to standard care. About 1,280 participants will be randomly assigned to either the simplifie…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests a drug called oxfendazole for people with mild brain cysticercosis, a parasitic infection that can cause seizures. Researchers will compare a single dose and three doses of oxfendazole against the standard combination therapy. The goal is to see if oxfendazole cl…

This early-phase study will test whether adding peginterferon alfa-2b to standard antiviral drugs can help prevent hepatitis B-related liver cancer from coming back after surgery. About 156 adults aged 18 to 65 will receive either the combination or antivirals alone. Researchers …

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…

This study tests whether adding Babao Dan Capsule (a traditional Chinese medicine) to standard antiviral treatment can lower the chance of developing liver cancer in people with hepatitis B-related cirrhosis who are at high risk. About 1,034 adults aged 18-65 with a specific TCM …

This study tests if a 3-day medicine called nitazoxanide can treat Cryptosporidium infection in 480 malnourished children aged 6-12 months in Bangladesh. The goal is to shorten diarrhea and clear the parasite from stool. Half the children get the medicine, half get a placebo, and…

This study tests whether a medicine called ursodeoxycholic acid (UDCA) can help lower bilirubin levels in people with acute viral hepatitis (types A or E). Bilirubin is a waste product that builds up when the liver is inflamed, causing jaundice. The trial will compare 88 adults w…

This study tests an AI-powered assistant (Union-Agent) designed to encourage people with chronic hepatitis B who have been diagnosed but not yet treated to start antiviral medication. The study will enroll 2000 adults in China who are eligible for treatment but haven't started. T…

This phase 2 trial tests an oral drug called ibezapolstat in 20 people who have had three or more C. diff infections in the past year. The goal is to see if the drug can cure the current infection and reduce the chance of it coming back. Participants will take the drug twice a da…

This study tests whether adding a traditional Chinese medicine called Biejia-Ruangan compound to standard antiviral therapy can lower the chance of developing liver cancer in people with hepatitis B-related cirrhosis. About 1,034 high-risk adults (based on a special score) will b…

This study looks at whether adding a specific probiotic (containing Enterococcus faecium and Bacillus subtilis) to the antibiotic rifaximin can improve treatment for small intestinal bacterial overgrowth (SIBO), a condition that causes bloating, pain, and diarrhea. About 100 adul…

This study tests if xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low or high dose of xylitol or a placebo for four weeks. Researchers …

This study tests whether giving two antiviral drugs—entecavir followed by pegylated interferon—can help children aged 3 to 6 with chronic hepatitis B achieve a functional cure (clearing the virus from the blood). About 80 children will be randomly assigned to receive either entec…

This study tests whether adding pegylated interferon to entecavir helps young children (ages 3-6) with chronic hepatitis B achieve a functional cure, meaning the virus becomes undetectable. Sixty children will receive either entecavir alone or entecavir followed by the combinatio…

This study tests whether adding a probiotic called Lacticaseibacillus rhamnosus GG to standard care (like rehydration fluids) can shorten the duration of acute infectious diarrhea in children. About 480 kids aged 1 month to 10 years in Turkey will take part. Half will get the pro…

This study looks at whether a special oral nutritional supplement, combined with dietary counseling, can improve growth in children who are not growing as expected. About 216 children will be randomly assigned to receive either the supplement plus counseling or counseling alone. …

This Phase 3 trial tests a drug called hepalatide (L47) in 150 people with chronic hepatitis D, a serious liver disease. Participants receive either the drug or a placebo daily for 48 weeks. The goal is to see if hepalatide can lower virus levels and normalize liver enzymes. Afte…

This study tests a minimally invasive laparoscopic procedure to drain pyogenic liver abscesses in 30 adults who cannot have standard drainage. The goal is to see if it leads to fewer complications, faster recovery, and lower recurrence compared to open surgery or needle drainage.

This pilot study tests whether xylitol, a common sugar alcohol, can safely clear C. difficile bacteria from the guts of people with inflammatory bowel disease (IBD). About 69 adults with mild or inactive IBD will take different doses of xylitol for up to 8 weeks. Researchers will…

This Phase 3 trial tests an injection called TVAX-008 for people with chronic hepatitis B. About 630 adults who have been on antiviral therapy for at least 6 months will receive either TVAX-008, a placebo, or an active comparator. The goal is to see if the treatment can clear hep…

This study tests two blood products used to control bleeding during liver transplant surgery. It compares a newer product, Intercept Fibrinogen Complex, to standard cryoprecipitate. The goal is to see if the newer product works as well or better at stopping bleeding. The study wi…

This phase 2 trial will enroll 82 stable liver transplant recipients with chronic hepatitis B to see if switching to entecavir orally disintegrating tablets (ETV-ODT) is safe and helps preserve kidney function. Participants will take the drug daily for 48 weeks, and researchers w…

This study will offer free hepatitis B testing to nearly 240,000 adults in Phichit, Thailand, who were born before 1992 and may have been infected before vaccines were available. Those who test positive will receive care and daily medication to control the virus and prevent liver…

This study compares two antiviral strategies—one using a single drug (TAF) and the other starting with two drugs (entecavir plus TAF) then switching to TAF alone—in 120 people with advanced hepatitis B-related liver cancer who are also receiving immunotherapy. The main goal is to…

This study tests whether a weekly injection of pegylated interferon alfa-2b for 48 weeks can help children and teens (ages 3–17) with chronic hepatitis B achieve a functional cure. The treatment group will be compared to an observation group receiving no drug or standard antivira…

This study compares two antibiotics, fidaxomicin and vancomycin, to see which one is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 60 adults with IBD will take one of the two antibiotics for 10 days and be followed fo…

This early-stage trial tests a new therapeutic vaccine (Hepadvax) in 40 adults with chronic hepatitis B. The vaccine is designed to boost the immune system to control or possibly clear the virus. Researchers will monitor safety, viral load, and immune responses compared to a stan…

This study will test a new rapid device called TruPlex that checks for HIV, Hepatitis B, and Syphilis using a single fingerstick blood sample. About 500 adults at risk for these infections will take part. Researchers want to see if the test is accurate and easy for trained staff …

This study will test a new computer tool that helps emergency doctors spot patients at high risk for hepatitis C and HIV. The tool uses a machine learning algorithm to analyze patient data and pops up an alert for the doctor. Researchers will compare this targeted screening with …

This study will check if a new device called MagIA H3S can accurately detect HIV, hepatitis B, hepatitis C, and syphilis in pregnant women in the Democratic Republic of the Congo. About 7,500 pregnant women will take part. The goal is to see if this quick test works as well as st…

This study looks at whether a new finger-stick test for hepatitis C, which gives results in about an hour, is acceptable to patients in the emergency department. Researchers will enroll 200 adults who have tested positive for hepatitis C antibodies but don't know if they have an …

This early-phase trial tests whether adding Ursodeoxycholic Acid (UDCA) to standard antibiotics can prevent Clostridioides difficile (C. diff) infection from returning. About 30 adults with C. diff and risk factors for recurrence will take UDCA three times daily for up to eight w…

This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can p…

This study tests whether taking oral vancomycin alongside other antibiotics can prevent Clostridioides difficile infection (C. diff) in people aged 65 and older. Participants are randomly assigned to receive either vancomycin or standard care. The goal is to see if the drug reduc…

This study tests whether a probiotic supplement in oral drops can prevent diarrhea in children aged 0-12 who are taking common antibiotics like amoxicillin. One thousand children will receive either the probiotic or a placebo during their antibiotic course, and researchers will t…

This study tests a diet rich in soluble fiber and natural osmotic sugars (the SOLOS diet) to see if it improves constipation symptoms in adults with functional bowel disorders like IBS-C. Researchers will track stool frequency, form, and symptom severity in 180 participants. The …

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This pilot study tests a one-time 'booster' session for people who inject drugs and their injecting partners, given right after finishing hepatitis C treatment. The session helps them set health goals, identify barriers, and improve communication to stay engaged in ongoing health…

This study looks at whether giving unnecessary antibiotics to malnourished infants with diarrhea harms their immune system's ability to fight future infections. Researchers will compare two groups of 150 Bangladeshi infants: one group receives only supportive care, while the othe…

This study looks at 2,500 people newly diagnosed with hepatitis C in France. Researchers will use existing medical data to map the different virus types and subtypes, including rare ones. The goal is to understand which types are most common and why some treatments fail, helping …

This study looks at adults who had a C. diff infection and were treated with either a fecal transplant (FMT) or antibiotics alone. Researchers want to see if FMT leads to healthier gut bacteria and fewer health problems years later. Participants will give blood, stool, and urine …

This study tests whether a pop-up alert in electronic medical records can help primary care doctors order screening for HIV, hepatitis B, and hepatitis C all at once. About 50 primary care providers will participate, and their patient visits will be randomly assigned to either se…

This study will give fecal transplants to 90 people with recurrent C. difficile infection, ulcerative colitis, or metabolic syndrome. Researchers will use advanced tests on stool and tissue samples to track how donor bacteria settle in the gut and interact with the host. The goal…

This pilot study will test a mobile app called ADEPT among 30 village doctors in Bangladesh. The app helps doctors decide when antibiotics are truly needed for children with diarrhea. The goal is to see if using the app reduces unnecessary antibiotic prescriptions, which is a maj…

This study will follow 352 pregnant women with chronic hepatitis B to see how often their liver enzymes rise after giving birth. Researchers want to find out what factors predict these spikes, especially comparing those who took antiviral drugs during pregnancy to those who did n…

This study will check 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have stomach pain, bloating, or diarrhea. Researchers will use breath tests to see if a condition called SIBO (too much bacteria in…

This study looks at how satisfied young people and those with low incomes are with free HIV and STI testing and counselling in Lucerne and Zurich. Around 1,800 participants will fill out a questionnaire after their visit. The goal is to see if these free services meet people's ne…

This study looks at how the hepatitis B virus changes over time in people taking antiviral drugs. Researchers will analyze blood samples from 700 adults in Turkey to see if the virus becomes resistant to treatment. The goal is to help doctors choose the best medications for each …

This study will follow 5,160 pregnant women in France who have HIV, hepatitis B, hepatitis C, or an arbovirus infection (like Zika or dengue), along with their children, for up to 7 years. Researchers want to learn how these viruses and their treatments affect pregnancy, the moth…

This study looks at how well telemedicine works to treat hepatitis C in people who are already getting care at opioid treatment programs. Researchers will review medical records from 200 patients to see how many start and finish their hepatitis C treatment. The goal is to make it…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study tests whether digital messages created by sex trafficking survivors can encourage more HIV, STI, and hepatitis C testing, as well as use of overdose prevention kits. About 368 survivors in New York City will be randomly assigned to see either survivor-made messages or …

This study looks at whether a rapid fingerstick test that gives results in 10-20 minutes can help more people get screened for HIV, hepatitis C, and syphilis during mobile clinic visits. About 200 patients of the WVU Street Medicine team can choose the rapid test, a traditional b…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This observational study looks at data and samples from 220 people with hepatitis D (HDV) who are already taking the medication bulevirtide. Researchers want to see how well the drug works over time and find markers that predict a good response. The goal is to improve monitoring …

This study follows 600 Chinese children who received standard vaccines against polio, measles, mumps, rubella, and hepatitis A. Researchers will test their blood to see if protective antibodies remain 5 years after vaccination. The goal is to understand how long vaccine protectio…

This study will look at 130 people with H. pylori-related gastritis to see if the infection is linked to anxiety, depression, or other psychological symptoms. Researchers will also check whether treating the infection improves mental health. The goal is to better understand the c…

This early-stage trial will test a new drug called hydronidone, which is being developed for liver fibrosis caused by hepatitis B. Since patients often need to take antiviral drugs for hepatitis B, researchers want to see if hydronidone can be taken safely alongside four common a…

This pilot study will test whether an 8-session telehealth program can help people who inject drugs in the rural South build coping skills and resilience. The goal is to improve access to HIV prevention (PrEP), hepatitis C treatment, and medication for opioid use disorder. The st…

This study will enroll 2,000 Egyptian patients with chronic hepatitis B to find out how common antiviral drug resistance is and what factors make it more likely. Researchers will look at patients taking common antiviral drugs like tenofovir, entecavir, or lamivudine. The goal is …

This study tests whether watching a single episode of the medical drama House M.D. can boost knowledge about neurocysticercosis, a parasitic brain infection that can cause epilepsy. Sixty young adults aged 18-35 will be randomly assigned to either watch the episode or not, and th…

This study will compare a new handheld device to the standard iLivTouch system for measuring liver stiffness and fat in 224 adults with chronic liver disease. Participants will be tested with both devices while lying down and sitting. The goal is to see if the handheld device is …

This study will screen 1,000 Chinese adults aged 18 to 50 living in Milan for hepatitis B and C using rapid finger-prick tests. Participants get counseling in Italian or Chinese, fill out a short questionnaire, and receive results the same day. The goal is to see if culturally ta…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…