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Experimental drug aims for functional cure in hepatitis b

NCT ID NCT07696520

Not yet recruiting Disease control Sponsor: National University Health System, Singapore Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This phase 2 study tests whether the drug bepirovirsen can achieve a functional cure for chronic hepatitis B in 30 adults with low virus levels. Participants receive weekly injections for 24 weeks and undergo liver biopsies to measure changes in the virus and immune response. The goal is to see if the virus can be suppressed enough to stop all treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Bepirovirsen
What this could lead to
If successful, this could point toward a functional cure for chronic hepatitis B, where the virus is suppressed without lifelong medication.
What could go wrong
This is an early phase 2 study with only 30 participants, so results may not apply broadly. The treatment involves weekly injections and liver biopsies, which carry risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection hepatitis B virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATITIS B CHRONIC INFECTION HEPATITIS B, CHRONIC

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Division of Gastroenterology & Hepatology, National University Hospital (NUH)

    Singapore, 119074, Singapore

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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