Dental caries

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This trial tests five different materials placed beneath composite fillings in back teeth to see which one best supports the filling and keeps it firmly attached. Adults needing a standard back-tooth filling will receive one of the five materials at random. Dentists will check th…

This study compares two ways to treat deep cavities in young permanent teeth without exposing the nerve. In selective excavation, the dentist removes only the outer decay and seals the tooth. In stepwise excavation, they place a temporary filling first and remove more decay a few…

This trial compares two marketed brands of silver diamine fluoride (SDF) to see which is more effective at stopping tooth decay in children aged 4 to 7. Both treatments are applied to cavities and leave a black stain. Researchers will follow the children for one year, checking wh…

This study tests whether a less invasive partial pulpotomy works as well as the standard full pulpotomy for treating deep cavities in children's baby molars. Both procedures use MTA, a material that helps heal the tooth's pulp. The trial enrolls healthy children aged 4-8 with mat…

This trial tests whether custom-made zirconia crowns hold up better than prefabricated ones in children's first permanent molars. Fifty children with badly decayed or damaged molars will receive one type of crown, and researchers will track retention, chipping, gum health, and fi…

This study compares two types of prefabricated crowns—zirconia and Bioflx—for restoring decayed or discolored front baby teeth in children aged 3 to 5. Each child receives one crown type, and researchers track gum health, plaque buildup, wear on the opposite tooth, crown retentio…

This study compares four types of tooth fillings for cavities on the sides of back teeth. Three of the fillings release minerals like calcium and phosphate, which may help repair the tooth and prevent further decay. The fourth is a standard bulk-fill filling used for comparison. …

This study tests whether 3D-printed composite resin fillings work as well as semi-direct composite resin fillings for cavities or damaged back teeth. About 60 adults aged 25 to 40 who need two similar fillings will get one of each type. Researchers will check for cracks, wear, an…

This study tests two methods of placing a bulk-fill composite filling material in cavities on the chewing surfaces of back teeth. One method places the material all at once, while the other builds it up in thin layers. Researchers will check how well each method holds up over tim…

This study tests a new dental filling made with coconut nanoparticles for children's baby teeth. Sixty children aged 5 to 9 with cavities will receive either the new coconut filling or a standard glass ionomer filling. Researchers will check the fillings' surface, shape, and how …

This study tests whether new plastic-like PEEK crowns work as well as standard metal crowns for children's back teeth after a common nerve treatment (pulpotomy). Sixty kids aged 5-9 got one PEEK crown and one metal crown on opposite sides of their mouth. Researchers checked gum h…

This study compares three types of bioactive dental fillings for cavities in back teeth. Fifty-five healthy adults aged 18 to 50 with at least three cavities will receive each filling type in different teeth. Researchers will check how well the fillings hold up, their appearance,…

This study compares a new injectable tooth filling material to a conventional one for treating cavities in back teeth (molars). About 120 people with cavities will receive one of the two fillings. Researchers will check how well the fillings hold up over time, looking at color, c…

This study compares two types of dental onlays (custom-made tooth covers) for treating decayed teeth. 164 adults will each receive one milled and one 3D-printed onlay to see which lasts longer over 10 years. The goal is to find out if the newer 3D-printing method is as good as th…

This study looks at two methods for placing glass ionomer fillings in the back baby teeth of 200 South African children aged 4-8. One method is done in a classroom using hand tools (ART), the other in a mobile clinic with standard equipment. Researchers will track how long the fi…

This study tests three different materials used to treat deep cavities in children's permanent molars that are still growing. The goal is to see which material best keeps the tooth alive and allows the root to finish forming normally. Sixty-nine children aged 7 to 10 will receive…

This study compares two ways of making dental onlays (custom tooth restorations) for damaged molars: milling from a solid block versus 3D printing. Thirty adults with cavities, broken teeth, or old fillings will receive either a milled or 3D-printed onlay. Researchers will check …

This study compares two types of dental cement used to place tooth-colored inlays (fillings) in cavities of back teeth. Fifty adults with large cavities or broken fillings will receive an inlay and be followed for 18 months to see which cement performs better in terms of strength…

This study tests a new high-strength ceramic material for dental crowns that can be made in a single appointment using a computer technique, avoiding the need for a temporary crown. 48 adults with a decayed, fractured, or poorly restored molar or premolar will receive the crown a…

This study looks at two materials, ferric sulphate and putty MTA, used to treat deep cavities in children's baby teeth. The goal is to see which one works better and is safer than a traditional chemical. Sixty healthy children will be treated and followed for up to a year to chec…

This study looks at how well a new type of tooth-colored ceramic (3D shaded zirconia) works for making dental crowns, onlays, and bridges in a single dental visit using a computer design and milling machine. About 82 adults aged 18 to 75 who need a crown or onlay on a back tooth …

This study tests whether a gel containing silver diamine fluoride can stop cavities in preschool children as effectively as the standard liquid version. About 630 healthy children with at least one cavity will receive the gel or solution every six months for 30 months. The goal i…

This study tests three non-drilling treatments—silver diamine fluoride, a self-assembling peptide, and fluoride varnish—to see if they can stop or reverse early cavities in children's baby teeth. About 90 kids aged 4-10 with early tooth decay will be randomly assigned to one of t…

This study looks at three different ways to treat deep cavities in children's baby molars without pulling the tooth. The treatments are two types of pulpotomy (removing part of the tooth nerve and placing a material on it) and an indirect pulp cap (leaving some decay and sealing …

This study tests whether a new tooth-colored crown (Bioflx) works as well as the standard metal crown for fixing severely decayed baby molars in children aged 4 to 10. Each child gets one of each type on opposite sides of the mouth, and researchers check durability, gum health, a…

This study tests whether using a diode laser before placing a special filling material (Biodentine) helps preserve more healthy tooth and reduces staining compared to using Biodentine alone. 48 adults with deep cavities in permanent back teeth are being treated and followed with …

This study tests three materials—amniotic membrane, mineral trioxide aggregate putty, and biodentine—for treating deep cavities in children's permanent molars that are still growing. The goal is to help the tooth root finish developing and avoid root canal or extraction. Seventy-…

This study tests three types of dental fillings—high-viscosity glass ionomer, bulk-fill composite, and conventional composite—in 110 adults with deep cavities. The goal is to see which material performs best and causes less irritation to the tooth's nerve. Participants are health…

This study tests whether a newer version of a blood-derived filling (Advanced Platelet-Rich Fibrin) helps bone and gums heal better than the standard version after a tooth is pulled and a dental implant is placed right away. Sixteen healthy adults with a badly decayed back tooth …

This study compares a new self-cured bioactive filling material to a standard one for treating deep cavities in back teeth. Twenty-five patients with two decayed molars will receive one of each filling, then be monitored for up to two years. Researchers will measure how well the …

This study compares a new bioactive filling material to a standard resin composite for treating cavities. 31 adults with at least two cavities will receive both types of fillings and be monitored for up to 4 years. The goal is to see which material performs better in terms of dur…

This study tested four different types of tooth-colored fillings (flowable resin composites) to see which works best for fixing cavities. Twenty-eight adults each received at least four fillings, and the fillings were checked over two years. The goal was to find out if newer, sel…

This study compared two types of tooth fillings for cavities between teeth. 23 adults received either a glass ionomer or a bulk-fill composite resin filling. The fillings were checked at regular visits over 4 years to see how well they held up. The goal was to find out which mate…

This study looks at how well tooth-colored fillings hold up in baby molars that have had a pulpotomy (a procedure to remove infected pulp) compared to similar fillings in teeth without pulpotomy. About 40 healthy children aged 3-9 will be followed for 24 months. The goal is to se…

This study tests three different dental cements used to attach prefabricated zirconia crowns to children's front baby teeth. Thirty-six children with cavities will receive crowns, and researchers will check crown retention, gum health, plaque buildup, and parent satisfaction at 1…

This study compares two types of tooth-colored fillings for cavities on the chewing surface of back teeth. One is a new injectable resin composite, and the other is a conventional composite. Over 24 months, researchers will check how well each filling stays in place, resists stai…

This study compares two types of tooth-colored filling materials for cavities between teeth. 54 healthy adults aged 18-60 received fillings using either a standard bulk-fill composite or a newer thermoviscous material. Researchers will check the fillings at 6 and 12 months for ho…

This study compares two materials used to make dental onlays (a type of tooth filling for molars): a high-performance polymer called BioHPP and a ceramic called lithium disilicate. Forty participants received onlays made from one of these materials. Researchers will evaluate how …

This study tests two new dental filling materials for cavities in back teeth. 65 adults with cavities or old fillings that need replacing will receive the new fillings and be checked for pain, function, and appearance over 5 years. The goal is to see if the materials are safe and…

This study tests a new dual-cure adhesive used to bond ceramic inlays and onlays to teeth. Researchers will check how often patients have tooth sensitivity after the procedure and how well the restoration holds up over time. 45 adults aged 18-65 with cavities in molars or premola…

This study tests a blue dye called BlueCheck to see if it can find early tooth decay and track whether the decay is healing. Twelve adults will wear a special denture with pieces of human tooth enamel for 28 days. The dye's results are compared to standard dental tools to see if …

Researchers are testing three mouthwashes, licorice, clove, and chlorhexidine, in Egyptian children aged 7 to 12 who have a high risk of cavities. The trial measures levels of Streptococcus mutans, a bacterium linked to tooth decay, in saliva before and after children use their a…

Researchers are testing whether fluoridated bottled water prevents tooth decay in young children. The trial enrolls 200 children starting at 2 to 6 months of age and follows them until around their fourth birthday. Families receive either fluoridated or non-fluoridated bottled wa…

Researchers at Trinity College Dublin are testing whether adding an adhesive bonding step before placing fissure sealants helps the sealants stay on children's permanent molars and prevents cavities. The trial includes 100 children aged 6 to 12 who are at high risk of tooth decay…

This study tests whether specially designed videos can help parents of young children prevent early childhood cavities. The program uses motivational messages to encourage good oral health habits. Researchers are following over 1,200 families enrolled in the WIC program in Iowa, …

This study tests two different dental sealants—a resin-based and a glass ionomer-based—on partially erupted permanent molars in children aged 10-15. The goal is to see which one lasts longer and prevents cavities better over one year. Forty healthy children will each get both typ…

This study tests simple educational programs for parents of children aged 9 months to 3 years. The goal is to see if these brief lessons can help prevent cavities and reduce behavior problems. Researchers will track dental records and behavior outcomes for 750 children.

This study tests a silver diamine fluoride (SDF) gel to prevent cavities in 1,500 healthy preschool children. The gel is applied every six months for two years and compared to standard fluoride varnish. The goal is to see if the SDF gel better protects teeth from decay.

This study aimed to see if chewing xylitol gum could prevent cavities in children aged 5 to 14 living in Ladakh, India. Participants would have chewed gum with either 100% or 22% xylitol daily for a school year. However, the study was withdrawn before any children enrolled, so no…

This study tests whether teaching children in Uganda how to brush their teeth, use fluoride varnish, and eat healthy foods can prevent cavities. About 610 school children aged 5-17 will be split into two groups: one gets the prevention program, the other does not. Researchers wil…

This study tests three approaches to prevent cavities in 180 children aged 6-7 in Karachi, Pakistan. One group brushes with fluoride toothpaste, another adds dietary advice, and the third also gets sealants on their back teeth. The goal is to find the most effective and affordabl…

This trial tests whether two dental cements, MTA and CIMMO DTA®, differ in reducing pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth—in children aged 6 to 16 with molar-incisor hypomineralization (MIH), deep decay, and irreversible pulpitis. Partic…

This study tests different ways of applying a dental adhesive and filling material to see which method keeps fillings intact and stain-free for up to 5 years. Fifty adults with cavities or old fillings needing replacement will receive four different filling types. The goal is to …

This study tests whether a virtual reality (VR) game can lower anxiety and pain in children aged 6 to 10 during their first dental treatment. Half of the 88 kids will wear VR glasses showing an interactive game that explains each step, while the other half gets the standard 'tell…

This study compares three types of dental onlays (a type of filling that covers part of a tooth) for treating cavities. It involves 36 adults who each need at least three onlays. The onlays are made using 3D printing, milling, or indirect resin composite. Researchers will check h…

This study surveys general dentists in two UK regions to understand their knowledge and use of silver diamine fluoride (SDF), a liquid that stops tooth decay without drilling or needles. Researchers aim to identify barriers like training gaps or cost that prevent wider use in chi…

This study looks at two common treatments for cavities in children's baby molars: ferric sulfate and sodium hypochlorite. Researchers will check how well each treatment worked by examining kids aged 4-9 during routine dental visits over 2 years. The goal is to see which agent lea…

This study looks at how two ways of cleaning cavities—removing all decayed tissue versus leaving some softer tissue near the nerve—change the types of bacteria left in the tooth. Researchers will take samples from 48 adults with cavities and analyze the DNA of the bacteria. The g…

This study follows 100 head and neck cancer patients receiving standard radiotherapy to see how their teeth, gums, and saliva change over time. Researchers measure gum health, tooth condition, and quality of life before and after treatment. The goal is to better understand these …

This study compares four different dental filling materials in 20 patients with cavities in their back teeth. The fillings are evaluated over 9 months for how well they hold up, look, and affect tooth health. The goal is to see if newer bioactive materials perform better than sta…

This study compares different types of dental tools (matrix systems) used to rebuild the shape of a tooth when filling large cavities. Ninety adults with large cavities on the side of a back tooth will receive a standard filling, and the quality of the filling's shape and contact…

This study compares four new single-shade universal resin composites to a conventional composite for filling class 2 cavities (between teeth). 45 adults will receive 180 fillings, which will be evaluated at 6 and 12 months by blinded dentists using standard criteria. The goal is …