Can a new dental cement ease pain after Tooth-Saving treatment in kids?

NCT ID NCT07774806

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This trial tests whether two dental cements, MTA and CIMMO DTA®, differ in reducing pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth—in children aged 6 to 16 with molar-incisor hypomineralization (MIH), deep decay, and irreversible pulpitis. Participants will receive the treatment on a permanent molar and report pain levels using a child-friendly scale during the first week. The goal is to find which material offers better pain control and helps preserve the natural tooth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mineral Trioxide Aggregate (MTA) or CIMMO DTA® dental cement used during pulpotomy
What this could lead to
If one material proves better at easing post-treatment pain, it could become a preferred option for saving damaged permanent teeth in children, reducing the need for more invasive procedures.
What could go wrong
This is a small, early-stage trial, and results may not apply to all cases. Pain relief can vary, and the materials may not show a clear difference.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 16 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged 6 to 16 years. * Presence of at least one permanent first molar diagnosed with Molar-Incisor * Hypomineralization (MIH), according to the criteria established by the European Academy of Paediatric Dentistry (EAPD). * Deep carious lesion involving the inner third of dentin, confirmed clinically and radiographically. * Diagnosis of symptomatic or asymptomatic irreversible pulpitis based on clinical examination, patient history, and pulp sensibility tests. * Tooth considered restorable after completion of treatment. * Presence of vital pulp tissue confirmed by bleeding following coronal pulp removal. * Child and parent/legal guardian able to understand study procedures and comply with follow-up requirements. * Written informed consent obtained from the parent or legal guardian and assent obtained from the child when applicable. Exclusion Criteria: * Teeth presenting clinical or radiographic signs of pulp necrosis. * Presence of spontaneous swelling, abscess, sinus tract, cellulitis, or other signs of acute odontogenic infection. * Evidence of internal or external root resorption. * Presence of periapical or furcation radiolucency suggestive of endodontic pathology. * Teeth with advanced periodontal disease or pathological mobility. * Teeth with root fractures, crown-root fractures, or extensive structural destruction that precludes definitive restoration. * Teeth in which hemostasis cannot be achieved within the time established by the study protocol after coronal pulp removal. * Children with systemic diseases or medical conditions that may affect healing or interfere with study outcomes. * Current use of medications that may alter pain perception, inflammatory response, or tissue healing. * Previous endodontic treatment or pulp therapy performed on the study tooth. * Inability or unwillingness of the participant or parent/legal guardian to attend follow-up visits.

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Conditions

The condition(s) this trial relates to.

dental caries Molar Hypomineralization pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Universidade Ceuma

    São Luís, Maranhão, 65075-120, Brazil

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