Can a new dental cement ease pain after Tooth-Saving treatment in kids?
NCT ID NCT07774806
First seen Aug 19, 2026 · Last updated Aug 21, 2026 · Updated 2 times
Summary
This trial tests whether two dental cements, MTA and CIMMO DTA®, differ in reducing pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth—in children aged 6 to 16 with molar-incisor hypomineralization (MIH), deep decay, and irreversible pulpitis. Participants will receive the treatment on a permanent molar and report pain levels using a child-friendly scale during the first week. The goal is to find which material offers better pain control and helps preserve the natural tooth.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mineral Trioxide Aggregate (MTA) or CIMMO DTA® dental cement used during pulpotomy
- What this could lead to
- If one material proves better at easing post-treatment pain, it could become a preferred option for saving damaged permanent teeth in children, reducing the need for more invasive procedures.
- What could go wrong
- This is a small, early-stage trial, and results may not apply to all cases. Pain relief can vary, and the materials may not show a clear difference.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2026
- Expected to finish
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Sep 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 to 16 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children aged 6 to 16 years. * Presence of at least one permanent first molar diagnosed with Molar-Incisor * Hypomineralization (MIH), according to the criteria established by the European Academy of Paediatric Dentistry (EAPD). * Deep carious lesion involving the inner third of dentin, confirmed clinically and radiographically. * Diagnosis of symptomatic or asymptomatic irreversible pulpitis based on clinical examination, patient history, and pulp sensibility tests. * Tooth considered restorable after completion of treatment. * Presence of vital pulp tissue confirmed by bleeding following coronal pulp removal. * Child and parent/legal guardian able to understand study procedures and comply with follow-up requirements. * Written informed consent obtained from the parent or legal guardian and assent obtained from the child when applicable. Exclusion Criteria: * Teeth presenting clinical or radiographic signs of pulp necrosis. * Presence of spontaneous swelling, abscess, sinus tract, cellulitis, or other signs of acute odontogenic infection. * Evidence of internal or external root resorption. * Presence of periapical or furcation radiolucency suggestive of endodontic pathology. * Teeth with advanced periodontal disease or pathological mobility. * Teeth with root fractures, crown-root fractures, or extensive structural destruction that precludes definitive restoration. * Teeth in which hemostasis cannot be achieved within the time established by the study protocol after coronal pulp removal. * Children with systemic diseases or medical conditions that may affect healing or interfere with study outcomes. * Current use of medications that may alter pain perception, inflammatory response, or tissue healing. * Previous endodontic treatment or pulp therapy performed on the study tooth. * Inability or unwillingness of the participant or parent/legal guardian to attend follow-up visits.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Universidade Ceuma
São Luís, Maranhão, 65075-120, Brazil
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Other studies related to the condition(s) this trial covers.
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