Cranial nerve neuropathy

This study planned to test whether injecting botulinum toxin (Botox) into the salivary glands could reduce drooling in people with true bulbar palsy, a condition that causes swallowing problems after a brain stem injury. The trial was designed to compare the injections against st…

This study compares a targeted drug called selumetinib to standard chemotherapy (carboplatin/vincristine) in children aged 2 to 21 with neurofibromatosis type 1 (NF1) and low-grade glioma, a type of brain tumor. The goal is to see if selumetinib works as well or better at control…

This study tests a new laser procedure called Direct Selective Laser Trabeculoplasty (DSLT) in 40 ethnic Chinese patients with glaucoma or high eye pressure. The laser aims to improve fluid drainage in the eye and reduce pressure. Researchers will check if the treatment is safe a…

This study tests whether high-dose nicotinamide (vitamin B3) is safe and can help people with dominant optic atrophy, a rare genetic disease that slowly damages the optic nerve and causes vision loss. Researchers will give 25 adults 3 grams of nicotinamide daily and monitor for s…

This study tests a new painless nerve growth factor eye drop (CHF6467) in 36 children and young adults with optic pathway glioma, a brain tumor that often causes vision loss. The goal is to see if the drops can protect or improve vision without the pain side effects of standard n…

This phase 2 trial tests whether glycerol phenylbutyrate (GPB) can slow corticobasal syndrome (CBS), a rare and fast-progressing brain disease. 32 adults with CBS will receive either GPB or a placebo for 26 weeks. The main goal is to see if GPB lowers levels of a nerve damage mar…

This expanded access program gave a single patient with Leber Hereditary Optic Neuropathy (a genetic cause of vision loss) an experimental gene therapy called GS010. The treatment was injected into both eyes to test safety. Only one person was involved, so the results are very li…

This phase 3 trial tests a gene therapy called NR082 for Leber's hereditary optic neuropathy (LHON), a genetic condition that causes rapid vision loss. About 95 people aged 12 to 75 with a specific ND4 mutation will receive a single injection of the therapy or a sham procedure. T…

This study tests a new medicine called PYC-001, given as an injection into the eye, for people with a genetic condition that damages the optic nerve (OPA1 optic atrophy). The main goal is to check if the treatment is safe and tolerable. About 18 adults will receive a single dose,…

This study tests whether a non-invasive brain-computer interface combined with mild electrical brain stimulation can improve facial movement in people with peripheral facial palsy. Thirty adults aged 18-70 with moderate to severe facial weakness will receive up to 20 sessions ove…

This study tests whether high-intensity interval training (HIIT) can improve eye health and slow disease progression in people with glaucoma. 168 adults aged 40-75 with open-angle glaucoma will be randomly assigned to either a supervised HIIT program or standard care with lifesty…

This Phase 2 trial tests an oral drug called FNP-223 in 241 people with progressive supranuclear palsy (PSP), a rare brain disorder that causes problems with balance, eye movement, and thinking. The study compares the drug to a placebo over 52 weeks to see if it can slow the dise…

This early study will test whether weak electrical currents applied to the head can help diagnose balance disorders like vestibular schwannoma and vestibular neuritis. Researchers will measure how 30 people with these conditions sway or move in response to the stimulation. The go…

This study tests an AI tool called AIDP that analyzes MRI scans to help diagnose Parkinson's disease and two similar conditions (MSA and PSP). Researchers at 21 sites will compare the AI's diagnosis to that of movement disorder specialists. The goal is to see if the tool can impr…

This study is testing a smartphone app called NEDS EyeCTester to see if it can help detect active eye disease early in people with conditions like optic nerve or macular disease. About 100 participants will use the app at home, and researchers will compare the results to standard…

This pilot study is testing whether yoga-based movements, done online or in person, can help people with chronic migraine or cluster headache. Twenty adults aged 18-65 will participate. The goal is to see if yoga improves headache frequency, sleep quality, and overall well-being …

This study tests whether two devices, used one after the other, can reduce pain and disability from temporomandibular joint (TMJ) disorders. Adults aged 22 and older with TMJ pain will receive four treatment sessions and be followed for three months. Researchers will measure chan…

This study looks at whether a 60-day nerve stimulation device placed near the back of the head can help people with stubborn headaches. Researchers will track pain levels, daily function, and how often participants need emergency care. About 300 adults with various headache types…

This study tests whether daily exposure to different scents can retrain the sense of smell in 250 adults with smell disorders, including those from traumatic brain injury. Participants will use scented inhaler sticks at home and take smell tests before and after 12 weeks. The goa…

This early study tests the safety of a new device called PRIMUS that uses mild electrical pulses on nerves in the forehead and back of the head to treat chronic cluster headache. Five people with frequent, hard-to-treat attacks will be enrolled. The goal is to see if the device i…

This study looks at whether adding a daily 30-minute muscle stimulation session can improve pain control and quality of life for people who already have a spinal cord stimulator (BurstDR) for chronic back pain. Sixty adults with failed back surgery syndrome or persistent spinal p…

This study tests a self-guided web program called Face-Forward-Web for adults with chronic orofacial pain (lasting over 3 months). The program includes five 30-minute video sessions teaching relaxation, mindfulness, and coping skills. Researchers will enroll up to 30 participants…

This study tests whether a home-based telenursing program, led by a specialist nurse, can improve quality of life and reduce complications like falls for people with atypical parkinsonism (MSA or PSP). About 164 participants will receive proactive and reactive remote monitoring a…

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study looks at whether online community support and telemedicine can improve quality of life for people with Parkinson's disease, Lewy body dementia, and related conditions, as well as their caregivers. About 632 participants will receive palliative care training for their d…

This study tests whether adding Kabat rehabilitation or kinesiology taping to standard facial therapy helps people with Bell's palsy recover better. 38 adults with one-sided facial paralysis will receive one of the two extra treatments for 8 weeks. Researchers will measure change…

This early-phase study tests whether MRI-guided focused ultrasound can safely reduce severe facial pain in people with trigeminal neuralgia that hasn't responded to medication. Ten adults aged 21-75 with chronic pain for over 6 months will receive a precise ultrasound treatment t…

This study tests a daily drug called basimglurant for adults with trigeminal neuralgia, a condition causing severe facial pain often called the 'suicide disease.' The trial includes 166 people who still have pain despite current treatments. After an 8-week run-in on the drug, par…

This study explores whether art therapy can help people with progressive supranuclear palsy (PSP) feel better and improve their daily life. Ten participants will take part in art sessions, and researchers will measure changes in quality of life, mood, and caregiver stress. The go…

This small study tests whether eptinezumab, a drug used for migraines, can reduce pain in people with atypical facial pain that hasn't responded to other treatments. Ten participants will receive two intravenous infusions three months apart. The main goal is to see if the drug im…

This study compares carbamazepine and oxcarbazepine, two drugs used to treat trigeminal neuralgia, a condition causing severe facial pain. Researchers will enroll 122 adults aged 18-60 who have had the condition for at least two weeks. They will measure pain relief using a standa…

This study tests a precise radiation treatment for trigeminal neuralgia, a condition that causes severe facial pain. Instead of a metal frame screwed into the skull, a special face mask holds the head still while x-rays target the painful nerve. The trial includes 40 adults whose…

This study tests whether low level laser therapy can improve facial function in people with Bell's palsy, a condition that causes sudden facial weakness. Researchers will compare laser therapy to routine physiotherapy in 100 adults aged 18 to 80. The main goal is to see if laser …

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to walking problems, falls, and thinking skills. The goal is to understand how t…

This natural history study follows 259 children, adolescents, and adults with Neurofibromatosis Type 1 (NF1) for up to 10 years. Researchers will track tumor growth, monitor quality of life, and perform genetic testing to better understand how the disease changes over time. The g…

This study aims to identify biomarkers—biological clues in the body—that can help distinguish between Parkinson's disease and similar conditions like progressive supranuclear palsy and multiple system atrophy. Researchers will follow people with early-stage parkinsonism and healt…

This study compares stainless steel and titanium-molybdenum alloy wires for moving canine teeth in people with braces. Sixteen participants will have one type of wire on each side of their upper jaw to see which works better. The goal is to find out which wire moves teeth more ef…

This study aims to better understand the autonomic nervous system (ANS), which controls things like heart rate and breathing without us thinking about it. Researchers will use simple, noninvasive tests (like cold water and deep breathing) to measure how the ANS responds in 48 hea…

This study will collect and analyze genetic data from 1000 people with suspected inherited metabolic diseases, including conditions like epilepsy and mitochondrial disorders. Researchers at Karolinska University Hospital aim to improve diagnosis by using advanced genetic testing …

This study uses advanced MRI scans and genetic tests to track how neurodegenerative diseases like frontotemporal dementia and ALS spread across the brain's network. Researchers will follow 645 participants, including patients, family members, and healthy controls, for up to 2 yea…

This study looks at people with trigeminal neuralgia, a condition that causes severe facial pain. Researchers want to see if adding virtual reality (VR) training before Gamma Knife surgery can improve pain relief. They will also use artificial intelligence (AI) and brain scans to…

This study looks at how headaches work by using capsaicin (the spicy part of chili peppers) and ice water to trigger mild, temporary pain in people with and without headache disorders. Researchers measure changes in pain signals and tear production to better understand conditions…

This study is testing whether wearable sensors can reliably monitor movement problems in people with progressive supranuclear palsy (PSP) and related frontotemporal disorders. About 60 participants will wear pendant-like devices for 12 months to track their activity. The goal is …

This study aims to discover new genetic mutations that cause mitochondrial disorders by analyzing tissue samples from up to 6,900 participants. It includes people with suspected or known mitochondrial diseases, such as MELAS or Leigh's Disease, who lack a genetic diagnosis. The r…

This study follows 150 people with rare neuroimmunologic disorders like neuromyelitis optica and transverse myelitis. Researchers collect medical data and blood samples over time to learn what causes inflammation and why some patients respond to treatments while others do not. Th…

This study aimed to find out how many people with trigeminal neuralgia (a severe facial nerve pain condition) also have temporomandibular disorder (TMD), which causes jaw pain. Researchers planned to follow patients from three clinics and test a questionnaire to better diagnose b…

This study looks at how changing your body position or drinking water can cause temporary spikes in eye pressure. Researchers will measure these changes in healthy volunteers and in people with glaucoma or autonomic dysfunction. The goal is to better understand what challenges th…

This study follows 300 children with congenital esotropia (crossed eyes from birth) who had corrective surgery. Researchers will analyze their genes and medical images to see how genetics and the timing of surgery affect eye alignment and the development of 3D vision. The goal is…

This study looks at how often a common heart side effect (first-degree atrioventricular block) occurs when verapamil is used at high doses to prevent cluster headaches. Researchers will monitor 60 patients starting or already on verapamil, using ECGs and blood tests. The goal is …

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study is creating a large, long-term collection of blood samples and health information from over 3,200 people with multiple sclerosis and related demyelinating diseases, as well as healthy volunteers. The goal is to provide scientists with a shared resource to better unders…

This study looks at whether a lung-opening technique called alveolar recruitment manoeuvre (ARM) affects brain pressure during laparoscopic hysterectomy. Researchers will use ultrasound to measure the optic nerve sheath diameter, a noninvasive way to estimate intracranial pressur…

This observational study looks at how brain inflammation contributes to frontotemporal lobar degeneration (FTLD), a group of disorders that cause dementia. Researchers will use advanced brain scans, blood tests, and spinal fluid analysis in 110 participants to find biomarkers tha…