Cranial nerve neuropathy

This study compares two types of special glasses (DIMS and DOT) to control nearsightedness in children aged 6 to 12 who also have intermittent exotropia (a type of eye misalignment). Researchers want to see which lens works better and whether the glasses affect eye coordination. …

This study tests whether insulin eye drops can protect the optic nerve in people with open-angle glaucoma. Researchers will give 90 participants either insulin drops or placebo daily for up to 12 months. The main goal is to check safety, but they will also measure vision changes …

This study compares two treatments given after emergency eye surgery for people with thyroid eye disease who have vision loss. One group gets teprotumumab, a newer drug that blocks a growth factor, and the other gets high-dose steroids. The goal is to see which one better improve…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests whether 12 sessions of visual therapy (eye exercises) can improve eye alignment and quality of life in people aged 8 to 50 with intermittent horizontal strabismus (eyes that sometimes wander). Participants are randomly assigned to either the therapy group or a no…

This phase 2 trial tests a combination of seven drugs (CL-Pola-R-CHP) in 28 adults aged 65 and older with double or triple-hit diffuse large B-cell lymphoma who are not eligible for transplant. The goal is to see how many patients achieve complete remission after six cycles of tr…

This study tests several experimental treatments for progressive supranuclear palsy (PSP), a rare brain disease that affects movement and thinking. About 440 people with early-stage PSP will receive one of the treatments or a placebo. The goal is to see if any of the treatments c…

This study tests a vaccine called AADvac1 in 146 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and thinking. The vaccine aims to target a protein linked to the disease and slow its progression. Participants will receive injections o…

This Phase 2 trial tests whether the drug LM11A-31 can slow the progression of Progressive Supranuclear Palsy (PSP), a rare brain disorder that affects movement and balance. About 147 people with early-stage PSP will receive either the drug or a placebo twice daily for several mo…

This study compares Botox injections to standard surgery for treating childhood esotropia (crossed eyes) in 244 children. The goal is to see if Botox, a less invasive option, works as well as surgery to straighten the eyes. If successful, it could reduce risks from surgery and an…

This study tests whether a laser treatment called DSLT can lower eye pressure and reduce the number of eye drops needed in Asian patients with normal tension glaucoma. About 40 adults will receive the laser and be followed for 12 months. The goal is to see if the laser can help c…

This early study tests whether high-dose vitamin B3 (nicotinamide) can help preserve or improve vision in people with Leber's hereditary optic neuropathy (LHON), a rare genetic disease that causes sudden vision loss. Researchers will give 13 participants 2 grams of vitamin B3 dai…

This study tests whether injecting Botox into the eye muscles can correct strabismus (misaligned eyes) without surgery. 127 children and adults with small-to-moderate eye turns will receive Botox injections, and their eye alignment will be tracked for a year. The goal is to see i…

This study will check if an AI system can accurately measure eye movements from smartphone videos. About 1,000 adults with suspected eye movement issues will record a short video while following a moving target. The AI's measurements will be compared to expert ratings to see if i…

This study looks at how quickly the optic nerve sheath shrinks after starting steroids in people with giant cell arteritis, a condition that can cause blindness. Researchers will use eye ultrasounds and blood tests over two months in 60 newly diagnosed patients. The goal is to fi…

Trigeminal neuralgia causes sudden, severe facial pain often mistaken for a toothache, leading to wrong treatments. This study tests a 15-question screening tool in 250 adults with facial pain to see if it can accurately identify possible trigeminal neuralgia before a specialist …

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study tests whether wearable augmented reality (AR) glasses can diagnose vertigo as accurately as standard eye-movement exams. About 200 adults with vertigo will try both methods during one visit. If successful, AR glasses could make vertigo assessment faster and more access…

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

This trial compares three treatments for idiopathic trigeminal neuralgia, a condition causing severe facial pain. One group gets standard carbamazepine alone, another adds the antiviral acyclovir, and the third adds the anti-inflammatory celecoxib. The goal is to see which combin…

This study tests whether low-energy shockwave therapy can improve facial nerve function in people with chronic Bell's palsy. Forty-two adults aged 45 to 55 will receive the treatment on specific points along the facial nerve. The goal is to reduce facial muscle weakness and impro…

This study tests whether adding low-level laser therapy to a minor bone-poking procedure (micro-osteoperforations) can speed up tooth movement in people with braces. About 33 patients aged 12-30 will have their canine teeth retracted after premolar extraction. The goal is to shor…

This study tests a 14-day home program called BraW-Day™ that combines brain exercises (like counting backwards) with walking, delivered via a smartphone app. Researchers want to see if doing both tasks together improves thinking, balance, and mood in athletes aged 18-40 who had a…

This study will test whether different types of electrical acupuncture can help adults recover from Bell's palsy, a condition that causes sudden facial paralysis. One hundred participants will receive either low-frequency continuous or intermittent electrical pulses over 4 weeks.…

This study compares two non-invasive laser treatments—high-intensity and low-level—for people with trigeminal neuralgia, a condition causing severe facial pain. About 38 adults who haven't found relief from medication or can't have surgery will receive one of the two laser therap…

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study tests whether watching 3D movies, combined with standard patching therapy, improves depth perception and vision in children aged 4 to 14 with amblyopia (lazy eye). Half the children will receive patching alone, while the other half will also attend weekly 3D movie sess…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can help people with Bell's palsy recover facial movement and reduce symptoms like drooping. About 111 adults who have had Bell's palsy for 3 weeks to 6 months will receive either real o…

This study compares two anesthesia methods for strabismus (eye muscle) surgery in adults: general anesthesia (being fully asleep) versus a combination of sedation with a local numbing injection around the eye. Researchers will measure patient and surgeon satisfaction with each ap…

This study tests whether a combination of gentle brain stimulation and visual exercises can improve vision and daily function in people with glaucoma who have lost some side vision. About 56 adults with open-angle glaucoma will receive both real and sham treatments in a crossover…

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can reduce pain in people with trigeminal neuralgia, a condition causing severe facial pain. 126 participants will either get real electroacupuncture or a sham version, while continuing …

This study tests two types of pulsed radiofrequency treatments for people with severe trigeminal neuralgia, a condition causing intense facial pain. 62 adults who haven't found relief from medication will receive either a standard or a new irregular-pulse technique. The goal is t…

This study tests whether watching 3D movies can improve depth perception and vision in children aged 4 to 12 who still have some vision loss from lazy eye (amblyopia) despite prior treatment. Forty children will be randomly assigned to watch three movies in either 3D or 2D, then …

This study tests whether patching the stronger eye in the morning (8-10 AM) or evening (5-7 PM) works better for improving vision in children with lazy eye (amblyopia). About 100 children aged 4-8 will wear an eye patch for 2-6 hours daily over 6 months. The goal is to see if tim…

This study compares two non-drug treatments—light therapy (photobiomodulation) and electrical stimulation—to see which better helps people with Bell's palsy regain facial movement. About 34 adults with moderate to severe facial weakness will receive one of the treatments along wi…

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This phase 2 trial tests whether low sodium oxybate (Xywav) can reduce nighttime cluster headache attacks in people with chronic cluster headache. About 52 participants will receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug lowers the number o…

This study tests if a long-lasting numbing drug (liposomal bupivacaine) injected into the scalp before surgery can reduce pain after a specific type of brain surgery called microvascular decompression. About 100 adults having this surgery will be randomly assigned to receive eith…

This study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…

This study explores whether tracking eye movements and arm motions during virtual reality driving tasks can help identify early signs of mild cognitive impairment (MCI) in older adults. Researchers will enroll 192 participants, including healthy young adults, healthy older adults…

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This study examines patients who have internuclear ophthalmoplegia, a condition that causes trouble moving the eyes sideways, to see how many later develop multiple sclerosis (MS). Researchers will review medical records of 200 patients to identify factors that predict MS convers…

This study will check if an artificial intelligence (AI) system can accurately measure facial paralysis in people with Bell's palsy. Currently, doctors use subjective scales that can vary between observers. The AI analyzes facial movements using a camera and compares its scores t…

This study looks at whether a common type of glaucoma eye drop (prostaglandin analogues) can protect the eye's nerve cells directly, not just by lowering eye pressure. Researchers will review medical records from 1500 adults with glaucoma over 3 years, comparing those on prostagl…

This study will test a wearable device called Syde® in 30 people with progressive supranuclear palsy (PSP-R). The device tracks movement and activity during daily life. Researchers want to see if patients find it easy to use and if the data matches standard clinic tests. The goal…

This observational study looks at 85 adults with Bell's palsy to see if worse facial muscle function is linked to higher anxiety, depression, and lower self-esteem. Researchers will measure facial movement and muscle activity, then compare those results with participants' answers…

This study will interview 30 children aged 6-17 who are undergoing chemotherapy for cancer, along with their parents, to understand how they deal with changes in taste, smell, and food texture. The goal is to learn what coping strategies families use at home and in the hospital t…

This study follows 62 people who need a second surgery for crossed or wandering eyes (strabismus). Researchers want to find out what factors increase the risk of needing repeat surgery and how successful the second operation is. Participants get a personalized surgical plan and a…

This study looks at how Gamma Knife radiosurgery affects brain connections in people with severe facial pain called trigeminal neuralgia. About 28 adults will get brain scans before treatment and at 1, 3, and 12 months after. The goal is to see if changes in brain wiring match pa…

This study looks at whether using artificial intelligence (AI) can help physical therapists make better treatment choices for people with myofascial pain syndrome (a type of muscle pain). About 70 adults with chronic muscle pain will be split into two groups: one gets therapy dec…

This study will look back at medical records of 45 people with either Wolfram syndrome or a related eye condition caused by changes in the WFS1 gene. Researchers want to see if these two conditions are truly different by comparing vision loss over time and other health problems. …

This study looks at 700 adults with trigeminal neuralgia who had a balloon compression procedure to relieve facial pain. Researchers will use machine learning to analyze past patient data and create a model that predicts if pain will come back. The goal is to identify key factors…

This study looks at people who had surgery for a severe facial pain condition called trigeminal neuralgia. Researchers want to know if dental treatments or other mouth stimulation after surgery can make the pain come back. About 100 participants will answer surveys about their pa…

This study will measure the width of the medial rectus tendon in 28 people having surgery for crossed eyes (esotropia). The goal is to see if tendon width is linked to how much the eye position changes after surgery. If a link is found, it could help surgeons plan more precise op…