Timing tylenol: could a fixed schedule beat 'as needed' for kids' post-surgery pain?

NCT ID NCT06689943

Terminated Symptom relief Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether giving children acetaminophen (Tylenol) on a strict schedule every 6 hours for 48 hours after strabismus surgery reduces pain more than the usual as-needed approach. About 80 children aged 4–12 will take part, with parents and children reporting pain scores. The goal is to see if a regimented course prevents underdosing and leads to better pain control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetaminophen (Tylenol) given on a fixed schedule every 6 hours for 48 hours after surgery
What this could lead to: If scheduled dosing works better, it could give parents a clearer, more effective way to manage children's pain after eye muscle surgery.
What could go wrong: This is a small Phase 2 trial, so results may not apply broadly. The difference between scheduled and as-needed dosing might be small, and the study does not test long-term outcomes.

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Conditions

The condition(s) this trial relates to.

Pain strabismus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STRABISMUS

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.