Congenital heart disease

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This study looks at whether moderate treadmill walking can improve how children aged 4 to 6 with surgically corrected acyanotic congenital heart disease walk, balance, and move. Eighty children will take part, with some doing treadmill sessions four times a week for 10 weeks. Res…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This study tests whether high-calorie diets and special nutritional formulas can help underweight children aged 1 to 5 with congenital heart disease gain weight. Seventy-five children will be split into three groups: standard diet, high-calorie diet, or high-calorie diet plus a s…

This early study tests a special cap that shines near-infrared light on the heads of infants who have had a cardiac arrest in the hospital. The light is meant to reduce brain injury caused when blood flow returns. The trial will include 30 infants with heart disease and will chec…

This trial tests a new device called Absnow II that closes a common heart hole (atrial septal defect) and then dissolves over time. About 236 people with a hole between 5 and 26 mm will get either the new device or a standard one. The goal is to see if the new device works just a…

This study tests whether a smartphone app powered by artificial intelligence can help adults recover after heart surgery. 500 patients will either use the app plus standard care or standard care alone. The app gives personalized advice on medications, spotting complications early…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This study tests whether a drug called a PCSK9 inhibitor (Tafolecimab) can slow the progression of mild to moderate calcific aortic stenosis, a condition where the heart valve narrows and hardens. Researchers will give the drug to half of 160 participants and compare changes in v…

This study tests whether giving the numbing drug lidocaine during heart surgery can reduce lung damage in infants. 320 babies under 1 year old having heart surgery will receive either lidocaine or a placebo. The goal is to see if lidocaine lowers the severity of lung injury after…

This study tests a drug called sotatercept in 40 adults with congenital heart disease and Eisenmenger syndrome, a serious condition where blood flow in the lungs is blocked. The drug is given as a shot every three weeks for 24 weeks. The goal is to see if it safely lowers pressur…

This study compares two medical devices used to close a small hole in the heart called a PFO, which can cause strokes. About 1,260 adults who have had a stroke or mini-stroke in the past year will be randomly assigned to receive either the Cocoon PFO Occluder or the Amplatzer PFO…

This study tests whether inserting a heart pump (IABP) early, before severe shock develops, can reduce deaths in patients who develop a hole in the heart after a heart attack. The trial will enroll 100 patients across 5 centers, randomly assigning half to receive the pump within …

This study tests whether dapagliflozin, a drug already approved for diabetes and heart failure, can improve exercise ability and heart function in people who have had the Fontan procedure. About 30 participants aged 12 and older will take the drug daily for 3 months. The goal is …

This large study tests whether closing a common heart hole (atrial septal defect) using only ultrasound guidance and special tools is as good as the standard X-ray method. The goal is to avoid radiation and contrast dye risks, such as cancer and kidney injury. About 666 participa…

This study tests a special heart valve that can be adjusted to fit children as they grow. It involves 36 kids aged 1.5 to 16 years with congenital heart disease who need a new pulmonary valve. The valve is placed during surgery and can later be expanded without another operation.

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests whether a butyric acid supplement, taken daily for three weeks before heart surgery, can safely improve gut health and reduce inflammation in infants and young children (ages 1 month to 3 years) with congenital heart disease. Researchers will monitor side effects…

This study will test a special balloon coated with the drug paclitaxel to treat long blockages in the leg arteries. About 300 people with severe leg pain or wounds will receive the balloon treatment during a standard angioplasty procedure. Researchers will track how well the arte…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study tests a WeChat mini-program designed to help families care for children after congenital heart disease surgery. The program provides health education, peer support, and remote monitoring. Researchers will compare families using the app to those receiving standard phone…

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This study tests the drug tirzepatide (Munjaro) in 30 obese adults with congenital heart disease. Over 6 months, half get the drug and half get a placebo. Researchers will check if it improves exercise ability, heart function, and cholesterol. It is one of the first studies to lo…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study tests a new biodegradable device that closes a common heart hole (PFO) in people who have already had a stroke or mini-stroke. The device is placed through a tube in the leg and dissolves over time, leaving no permanent implant. The trial will check if it safely and ef…

This study tests a new way to close a common heart hole (atrial septal defect) using only ultrasound, without X-rays or cuts. The procedure is done inside a specially equipped mobile surgical unit, bringing care to remote areas. About 300 people aged 8 and older will take part to…

This pilot study tests whether actively managing blood pressure during heart surgery in newborns can reduce dangerous low blood pressure episodes. About 130 newborns will be randomly assigned to either standard care or a new approach using a special monitor to keep blood pressure…

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests a small, handheld ECG device that records heart activity when held against the chest and sends the data via smartphone to a doctor. Researchers will enroll 594 adults with known or suspected heart conditions to see if the new device is as good as the standard 10-…

This study looks at 115 children aged 6 months to 5 years who have a hole in the heart (VSD) and need surgery. Doctors want to see if an ultrasound probe placed in the food pipe (TEE) can measure heart pressure as accurately as the standard method using a thin tube (catheter) ins…

This study tests a new cardiac MRI method called Free-Running Framework (FRF) that lets patients breathe normally and skips the sticky ECG electrodes. It captures a 3D image of the whole heart in one go, potentially making scans faster and more comfortable. Researchers will compa…

This study will check if a fast, bedside heart ultrasound performed by emergency doctors or interpreted by artificial intelligence can accurately detect heart problems in children who already have heart disease. About 200 children aged 0-21 will be included. The results will be c…

This study will check how accurate chest X-rays are at finding congenital heart disease in newborns. Researchers will study 60 babies in the NICU who show signs of heart problems. Each baby gets a chest X-ray within 24 hours and an echocardiogram within 72 hours. By comparing the…

This study looks at how CT scans can help doctors identify heart and blood vessel problems in children with Tetralogy of Fallot, a serious heart condition present at birth. About 37 children up to 12 years old will get a CT scan to find hidden issues and help plan surgery. The go…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests whether structured play activities, done with a parent, can reduce anxiety in children with congenital heart disease before their surgery. About 204 children aged 0-12 will be randomly assigned to either receive therapeutic play plus standard care, or standard ca…

This study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study tests whether playing motion-sensing Nintendo Switch games can help children and teens with congenital heart disease become more physically active. Thirteen participants aged 8-18 will wear activity monitors and follow a 12-week exergame program with coaching and suppo…

This study tests a virtual psychological support program called HeartGPS for mothers whose babies are diagnosed with congenital heart disease before birth. About 210 mothers and their infants will take part, with some receiving the program plus usual care and others only usual ca…

This study tests whether playing soft music or using a musical mobile can reduce pain and stress in infants when chest tubes are removed after heart surgery. Fifty-four babies aged 2 to 12 months will be randomly assigned to hear music, see a musical mobile, or receive standard c…

This study tests a digital exercise program that adapts in real time to help children aged 6 to 12 recover after congenital heart disease surgery. Kids wear a monitor and get personalized exercise prompts and feedback. Researchers will compare their recovery to children receiving…

This study looks at whether a multifunctional baby carrier that rocks, swaddles, and plays white noise can help infants (0-3 months old) feel less pain, sleep better, and have steadier heart rates and oxygen levels after congenital heart surgery. About 52 babies will be randomly …

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study looks at whether using clear, non-blood fluids to fill the heart-lung machine during surgery can reduce inflammation in infants having a hole in the heart repaired. Sixty babies aged 1 to 18 months will be enrolled. Researchers will measure inflammation markers and rec…

This study looks at whether a 12-week family walking program called Family WISH can improve frailty, quality of life, and family functioning in teens aged 12-18 with congenital heart disease. About 104 participants will walk with family members for 20-30 minutes daily, at least 5…

This study looks at whether adding special breathing exercises to aerobic training can improve lung function, exercise ability, and quality of life in adults who had surgery for Tetralogy of Fallot, a heart condition. Sixty participants will be split into two groups: one does bre…

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study tests two ways to deliver a group training program for caregivers of children with autism in low-resource areas. The program aims to reduce caregiver stress and improve the child's communication and behavior. About 320 caregivers of children aged 2 to 8 will take part.…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study is creating a decision aid for people with a rare heart condition called right anomalous aortic origin of a coronary artery (R-AAOCA). The condition raises the risk of sudden cardiac death, but the best management—surgery or careful observation—isn't clear. The aid wil…

This study checks whether three common ECG-based methods can accurately locate where abnormal heart rhythms start in adults who had Tetralogy of Fallot repair. Researchers will pace the heart from known spots during a scheduled procedure and compare the predicted location to the …

This study aims to collect blood samples from 450 people, including individuals with autism spectrum disorder (ASD), their relatives, and healthy controls. Researchers will isolate cells from the blood to study genetic factors and biological processes linked to autism. The goal i…

This study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…

This study tests a new method to measure central venous pressure (a key heart health indicator) without inserting a catheter. Researchers will use a pressure cuff and Doppler sensor on the forearm of 30 children (ages 0-17) in the intensive care unit. The goal is to see if this n…

This study tests a special breastfeeding guideline for infants born with congenital heart disease (CHD). Researchers want to see if the guideline helps more mothers breastfeed directly and reduces stress. About 266 mother-infant pairs will take part across multiple hospitals, wit…

This study tests a nursing support program for families of children aged 1 to 3 who have had heart surgery. The program includes education and counseling sessions to help parents improve caregiving skills and support their child's growth. Researchers will compare families who rec…

This study looks at how the heart's upper and lower chambers change shape and function after closing a hole called patent ductus arteriosus (PDA) using a catheter-based procedure. It will include 40 people aged 12 and older who are already scheduled for the closure. The goal is t…

This study looks at whether a special breathing maneuver during heart surgery can improve heart and lung function in children with congenital heart disease. About 80 children will be randomly assigned to receive either the maneuver or standard care. The goal is to see if this app…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This observational study will enroll 1,000 pregnant women and their fetuses to establish normal ranges for heart sounds and ECGs. The goal is to develop early warning systems for serious heart events in mothers, progression of fetal heart defects, and autoimmune-related fetal hea…

This study looks at whether children who had surgery to close a large hole in their heart (called a VSD) will catch up in growth. Researchers will measure weight, height, and BMI before and after the procedure in 58 children aged 1 month to 2 years. The goal is to see how long it…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This three-year study in 410 adults with congenital heart disease aims to see if AI-powered voice emotion detection can predict frailty and improve mental health. Participants will complete surveys and interviews, and some will receive AI-guided counselling. The goal is to better…

This study looks at whether certain proteins in the blood can signal brain injury in children who have heart surgery with a heart-lung machine. Researchers will measure these proteins before and after surgery and compare them to the child's brain function. The goal is to find a s…

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This study looks at how leg muscle size and strength affect circulation in people born with a single-chamber heart, a condition where the heart can't pump blood to the lungs on its own. Researchers will measure muscle mass, oxygen use, and quality of life in 40 adults aged 16-50 …

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study focuses on extremely preterm infants (born before 32 weeks) who have a heart condition called hsPDA. Researchers will collect blood samples and health data to create a model that predicts which infants need treatment. They are also developing a targeted drug-delivery s…

This study will review medical records of 72 children aged 1 month to 2 years with congenital heart disease (CHD) to see how their growth compares to healthy children. Researchers will measure weight, height, and head circumference. The goal is to understand which types of CHD af…

This study looks at 22 children with congenital heart disease who are getting a blood thinner called heparin. Doctors want to see if taking blood from a central line (a special IV) gives the same results as taking blood from an artery. They will compare three different ways of dr…

This study will test a handheld device called IntraOx that uses light to measure oxygen levels in heart and liver tissue during complex heart surgery in children. The goal is to see if it can give surgeons useful information about blood flow without interfering with the operation…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…

This study looks at how heart procedures change mental health in people with congenital heart disease. About 60 patients will complete surveys on mood, thinking, sleep, and eating before surgery, one month after, and three months after. The goal is to help doctors better screen a…

This study looks at how the antibiotic cefazolin spreads in the chest tissue of 10 children after heart surgery for congenital heart disease. A small probe placed during surgery will measure drug levels over 36 hours. The goal is to create a computer model to help doctors give th…

This study will test a new, non-invasive ultrasound technique that captures brain blood flow in real time for infants with congenital heart disease. Researchers aim to understand how medical treatments and surgeries affect the brain, potentially explaining why some children later…

This study will measure a specific heart function index in 2,640 healthy adults and people with heart conditions using AI-enhanced 3D ultrasound. The goal is to establish normal ranges and see how this measurement changes in diseases like heart failure and high blood pressure in …

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study will examine 106 infants under two years old who have cholestasis (a liver condition) to see how many also have congenital heart defects and how their development is affected. Researchers will use echocardiograms and developmental assessments. The goal is to better und…

This study will examine 138 children with congenital heart disease to find out how many also have chromosomal abnormalities. Researchers will use a standard genetic test called karyotyping to look for missing or extra chromosomes. The goal is to improve diagnosis, treatment plann…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…