Heart hole repair without X-Rays: major trial launches

NCT ID NCT07054541

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This large study tests whether closing a common heart hole (atrial septal defect) using only ultrasound guidance and special tools is as good as the standard X-ray method. The goal is to avoid radiation and contrast dye risks, such as cancer and kidney injury. About 666 participants will be randomly assigned to either the ultrasound or X-ray group, and a separate group of patients who cannot have X-rays will also be studied.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ultrasound-guided procedure with specialized instruments

What this could lead to

If successful, this could offer a safer, radiation-free and contrast-free way to close heart holes, reducing long-term cancer risk and allowing treatment for pregnant women and those with allergies or kidney problems.

What could go wrong

This is a Phase 4 trial, but it is not yet recruiting. The ultrasound method may not be as effective as the standard X-ray method in all cases, and the specialized instruments may not work for every patient.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

atrial septal defect atrial septal defect, ostium secundum type

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Chinese Academy of Medical Sciences, Fuwai Hospital

    Beijing, Beijing Municipality, 100037, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact