Could a simple supplement protect Kids' guts during heart surgery?

NCT ID NCT06882772

Not yet recruiting Disease control Sponsor: University of Nebraska Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a butyric acid supplement, taken daily for three weeks before heart surgery, can safely improve gut health and reduce inflammation in infants and young children (ages 1 month to 3 years) with congenital heart disease. Researchers will monitor side effects, changes in gut bacteria, and markers of inflammation. The trial aims to see if this simple approach can help kids recover better after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Butyric acid (SunButyrate-TG)
What this could lead to: If it works, this could point toward a simple, safe way to improve gut health and reduce inflammation in young children after heart surgery.
What could go wrong: This is an early phase 2a trial with only 105 participants, so results may not be conclusive. The supplement may cause side effects like vomiting or diarrhea, and it might not improve outcomes as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

congenital heart disease Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONGENITAL HEART DISEASE (CHD)

Contacts and locations

Locations

Children's Nebraska, 8200 Dodge St

Omaha, Nebraska, 68114, United States

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Other studies related to the condition(s) this trial covers.