Colorectal adenoma

This study follows 404 people who previously had either an AI-assisted or conventional colonoscopy. Researchers want to see if AI help lowers the risk of developing advanced colon polyps later. Participants will undergo a surveillance colonoscopy to check for new growths.

This study compares two methods used during colonoscopy to remove large, flat colon polyps: marking the edges before removal or using heat to treat the edges after removal. The goal is to see which method better prevents polyps from growing back. About 342 adults with polyps 20 m…

This study is testing whether a blood test can accurately identify colorectal cancer or polyps in adults referred for suspected lower GI cancer. Participants provide a blood sample during their routine diagnostic visit, and their results are compared to their final diagnosis. The…

This study is exploring whether molecular clues in stool and saliva samples can predict the presence of colorectal polyps. About 1,000 adults scheduled for a colonoscopy will provide samples beforehand, which will be analyzed and compared with their colonoscopy results. The goal …

This study tests a new blood test that looks for special molecules called ofCS, which reappear in most colorectal cancers. Researchers will collect blood and stool samples from 2000 people scheduled for a colonoscopy in Denmark. The goal is to see if combining the blood test with…

This trial tests whether a 3D imaging device used during colonoscopy helps doctors find high-risk adenomas—polyps that could turn into cancer—better than the usual 2D view. Adults aged 18-75 scheduled for a diagnostic colonoscopy will be randomly assigned to either a 2D or 3D sco…

This study aims to develop a new, non-invasive diagnostic tool for colorectal cancer by analyzing gut microbiome signatures in stool samples. Researchers will enroll 1006 participants aged 50-74 who have tested positive on the standard fecal immunochemical test (FIT). By combinin…

This study is looking at whether the mix of bacteria in the gut can serve as a warning sign for colorectal cancer and advanced polyps. Researchers will collect stool samples from people aged 50-74 who are part of a national screening program and have had a positive fecal immunoch…

This study compares two ways to monitor older adults (ages 65-82) who have had colon polyps in the past: an annual stool test (FIT) or a colonoscopy every few years. About 9,000 participants will be randomly assigned to one of the two methods and followed for up to 11 years to se…

This study is testing a new blood test called DENEB that looks for tiny molecules (microRNAs) to find colorectal cancer and precancerous polyps early. Researchers will collect blood samples from 2,000 people who are also getting a colonoscopy. The goal is to see if the blood test…

Colon cancer is common but preventable if caught early. While colonoscopy is the best screening tool, many people can't get one due to cost or time. This study collects stool and blood samples from 1,200 adults to find proteins that signal colon polyps or cancer. The goal is to d…

This study compares three ways to screen for colorectal cancer in average-risk people aged 45-74: colonoscopy, a stool test (FIT), and a stool test plus a blood test. Over 60,000 participants will be randomly assigned to one of the three methods. The goal is to see if the simpler…

This study is testing whether a blood test that measures a protein called MMP14 can help screen for colorectal cancer. Researchers will enroll 650 people aged 50 to 74 who already need a colonoscopy after a positive stool test. By comparing MMP14 levels with colonoscopy results, …

This study is testing an artificial intelligence system that helps doctors find precancerous polyps (called adenomas) in the colon during a colonoscopy. The AI analyzes images from a special scope to predict which polyps are dangerous. Researchers will enroll 4,000 adults to see …

This study is testing a blood test (called a liquid biopsy) to see if it can find colorectal cancer, pre-cancerous growths (adenomas), and cancers linked to Lynch syndrome at an early stage. Researchers will enroll 1,200 people who have already had a colonoscopy. The goal is to s…

This study compares two ways to monitor people who have had polyps removed from their colon: a fecal test that checks for blood in stool versus a standard colonoscopy. Researchers want to see if the simpler stool test is just as good at catching new cancers or high-risk polyps. A…

This study tests a tool called SCALE-EYE that helps doctors measure the size of polyps during a colonoscopy. The goal is to see if it works better than current methods and can reduce the number of follow-up colonoscopies, waste, and carbon footprint. About 241 people aged 55-80 h…

This study is testing whether a tiny camera in a pill (colon capsule endoscopy) can find colorectal cancer or precancerous growths in people who have had a bloodstream infection with certain gut bacteria. About 100 adults will swallow the camera 4-8 weeks after leaving the hospit…

This study is testing a blood test that looks for DNA fragments to detect colorectal cancer and advanced adenomas. Researchers will collect blood samples from 1,300 people in the U.S., including those with suspected cancer or adenomas and those undergoing routine screening. The g…

This study aims to create a blood test that can detect colorectal cancer and advanced polyps early. Researchers will use artificial intelligence to combine molecular markers and personal risk factors. The test will be developed and validated in 510 adults undergoing colonoscopy o…

This study tests a new microwave-based device, called MiWEndo, that is used during a standard colonoscopy to help doctors find polyps in the colon. About 50 people who already have a polyp in their rectum will take part. The goal is to see if the device is safe and can find more …

This study looks at whether analyzing the bacteria in stool samples with artificial intelligence can better predict colorectal cancer risk than the standard stool test. Researchers will collect samples from 2,500 people aged 50-75 who are already scheduled for a colonoscopy. The …

This early-phase study tests the safety of a drug called ONC201 (dordaviprone) in 36 adults at high risk for colorectal cancer due to familial adenomatous polyposis (FAP) or a history of many polyps. The drug aims to kill precancerous cells without harming normal ones. Researcher…

This study compares two ways to prevent colon cancer in people who have had multiple advanced polyps removed. One group gets a standard colonoscopy after three years, while the other group does a simple stool test every year for two years, and only gets a colonoscopy if the test …

This study tests whether eating more plants and fewer animal foods can lower colorectal cancer risk. Researchers will measure changes in bile acids, gut bacteria, and other markers in 40 adults who have had colon polyps removed. Participants follow a self-guided diet for several …

This study tests whether taking a probiotic called Clostridium butyricum can prevent colorectal adenomas (precancerous polyps) from returning after they are removed during a colonoscopy. About 294 adults aged 18-75 who have had all visible polyps removed will take either the prob…

This study tests whether giving personalized diet and lifestyle advice to people who had a positive colorectal cancer screening (but no cancer) can help them adopt healthier habits and potentially prevent future cancer. 800 participants will be randomly assigned to receive the ad…

This study tests whether using a computer-aided detection (CADe) system during screening colonoscopy helps find and remove more advanced polyps, potentially lowering the risk of colorectal cancer. About 592 adults at increased risk for colorectal cancer will be randomly assigned …

This early-phase study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower biological markers linked to colorectal cancer risk. Researchers will enroll 20 adults aged 18-50 with a BMI between 27 and 40 who have had a recent colonoscopy. The goal is to s…

This study tests whether Shenling Baizhu granules, a traditional Chinese medicine, can prevent low-risk colorectal adenomas from recurring after they are removed during a colonoscopy. About 624 adults aged 18-70 will take the granules three times daily for six months or receive n…

This study tests whether drinking carrot juice rich in natural compounds called polyacetylenes can stop new polyps from growing in people who have already had large or high-risk polyps removed. Four hundred participants will drink either special carrot juice or a placebo juice da…

This study tests whether a device called GelPOINT® Path can improve the removal of colorectal polyps during a procedure known as endoscopic submucosal dissection (ESD). The device is designed to give doctors better access, stable air pressure, and clearer views inside the colon. …

This study tests a new gel called SUBMO® to see if it works as well as the standard saltwater solution for lifting and removing large colon polyps (over 10 mm) during a colonoscopy. About 300 adults will take part. The goal is to make the removal process smoother and safer.

This study is building a risk prediction model for colorectal adenomas (precancerous polyps) by combining data from both Traditional Chinese Medicine (like tongue and pulse diagnosis) and Western medicine (like endoscopy and lab tests). Researchers will follow 3,000 adults across…

This study looks at how eating different amounts of cysteine—a protein building block—affects gut bacteria and inflammation in people at higher risk for colon cancer. Researchers will compare Black and White adults aged 45-75 who have had colon polyps. Participants will follow bo…

This study looks at 300 people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer. Researchers want to understand why some patients still develop cancer even with regular check-ups. They will analyze blood, gut bacteria, and hair samples to find cl…

This study tests whether a digital training program called Colo-ID helps doctors better predict the type of colon polyps they see during a colonoscopy. About 1,500 adults with at least one polyp will take part. Doctors will record their predictions before and after training, and …