Bowel dysfunction

This study compared two surgical techniques for treating Hirschsprung's disease in children: the traditional Soave method and a newer heart-shaped anastomosis. The trial involved 177 children under 14 years old across multiple hospitals. The goal was to see which approach leads t…

This study looked at 20 children with Hirschsprung disease, a condition where part of the bowel lacks nerve cells, causing severe constipation. Researchers compared two surgical methods—Swenson and Soave—to see which one had shorter operation time and better daily bowel movements…

This study looked at the long-term safety of the drug linaclotide in children aged 6 to 17 with functional constipation or irritable bowel syndrome with constipation (IBS-C). A total of 381 children who had already completed earlier studies took linaclotide for 24 or 52 weeks. Th…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study looked at 60 women with deep endometriosis in the rectum to compare two surgical approaches: removing the affected part of the rectum versus just cutting out the endometriosis nodules. The goal was to see which method leads to fewer long-term bowel and bladder problems…

This study tested a two-part surgery for children with severe constipation that didn't get better with standard treatments. The surgery removes part of the colon and creates a small opening in the belly for enemas. The goal was to reduce accidental stool leakage (soiling). The st…

This early study tested a wireless patch that uses a tiny electric current to push two drugs (neostigmine and glycopyrrolate) through the skin and into the blood. The goal is to help people with spinal cord injury have predictable bowel movements without needles. Only 2 healthy v…

This phase II trial tested the drug isatuximab in 43 patients with AL amyloidosis that had come back or stopped responding to treatment. Isatuximab is a monoclonal antibody that may help stop abnormal protein buildup. The study measured how well the drug reduced disease markers a…

This study tested two ways to stimulate sacral nerves in 48 children aged 2-17 with severe constipation and fecal incontinence that didn't improve with standard care. One group got an implanted nerve stimulator, the other a non-invasive patch. The goal was to see if either approa…

This study tested a new, locally made capsule to see if it can accurately diagnose slow-transit constipation. Twenty healthy volunteers and people with constipation took both the new capsule and a standard capsule at the same time. After five days, an abdominal X-ray counted how …

This study tested whether a new device called EndoFLIP can better diagnose anismus, a condition where the anal muscles don't relax properly during bowel movements, causing severe constipation. Researchers measured anal stretchiness in 61 patients with chronic constipation and com…

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve symptoms of chronic constipation in adults. One hundred participants took either the probiotic or a placebo for a period, and researchers measured changes in stool consistency and gut bacteri…

This trial investigates whether drinking coffee after pancreatic surgery can help the bowel start working again sooner. About 200 adults who had open pancreatic surgery will receive either regular coffee, decaf coffee, or water twice a day. The main goal is to see how quickly the…

This study tested whether naldemedine, a drug already used for opioid-induced constipation, can also prevent nausea and vomiting when cancer patients start strong painkillers. 120 adults with cancer who were beginning opioid therapy took either naldemedine or a placebo for up to …

This study tested a new device called MOWOOT for people with chronic constipation. 86 adults who already used standard treatment (trans-anal irrigation) tried the MOWOOT device to see if it improved their symptoms and quality of life. The goal was to compare the new device's effe…

This study tested a hands-on therapy called visceral osteopathy for people with functional constipation. 27 adults received either osteopathic manual therapy or standard dietary advice. The goal was to see if the manual therapy could improve bowel symptoms and quality of life bet…

This study tested health and wellness products to see if they could improve common stomach issues like gas, bloating, diarrhea, and constipation. About 500 adults from across the U.S. took part. Participants took either the product or a placebo (a dummy pill) and reported their s…

This pilot study tested a drug called TD-1211 in 95 people who had constipation from taking opioid pain medications. The main goal was to see if the drug was safe and tolerable. Researchers also looked at whether it increased the number of complete and spontaneous bowel movements…

This study tested a drug called TD-1211 in healthy volunteers and people with constipation caused by opioid painkillers. The goal was to see if it is safe and helps with bowel movements. Participants took different doses of TD-1211 or a placebo, and researchers monitored their sa…

This study tested a drug called TD-1211 in 217 adults who have constipation because of opioid painkillers. The goal was to see if it safely increases the number of complete spontaneous bowel movements each week. Participants took either the study drug or a placebo for several wee…

This study tested a new drug called TD-1211 in 69 adults who had constipation because of opioid painkillers. The goal was to see if the drug is safe and helps people have more bowel movements. Participants stopped using other laxatives during the study to see how well TD-1211 wor…

This study tested the drug linaclotide in children aged 2 to 5 years with functional constipation, a common condition with no approved treatments. In the first part, children received either linaclotide or a placebo for 12 weeks to see if it increased bowel movements. In the seco…

This study tested whether a daily mix of a special fiber (guar gum) and a probiotic (Lacticaseibacillus rhamnosus GG) could help children with long-term constipation. Fifty-two children aged 4 to 16 took either the supplement plus diet advice or just diet advice for 12 weeks. Res…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether applying a magnetic field to the belly can reduce constipation severity. 75 adults with chronic constipation were split into three groups: one received active magnetic therapy twice a week for 8 weeks, one received a sham treatment (device on but no magn…

This study tested a low-volume irrigation device (Qufora IrriSedo MiniGo) in 92 adults with fecal incontinence, chronic constipation, or both. Participants used the device at home to see if it improved bowel function and daily life. The goal was to find a simple, non-drug option …

This study looked at whether giving people a gentle abdominal massage before surgery could help prevent constipation after the operation. Sixty adults who were already constipated and scheduled for general surgery took part. Half received a 15-minute massage twice a day before su…

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

This pilot study tested whether a daily prebiotic fiber bar is safe and tolerable for people with Parkinson's disease. Twenty adults (ages 60-75) ate one bar each day for four weeks. Researchers checked gut symptoms, quality of life, and markers of intestinal inflammation from bl…

This study tested whether a probiotic called Bifidobacterium longum can ease constipation in infants and toddlers. 84 children received either the probiotic, a common laxative (lactulose), or both for 28 days. Researchers tracked bowel movements, stool consistency, and gut bacter…

This study tested a constipation training program for mothers of children aged 4-6 with functional constipation. The program used motivational interviewing to help mothers manage their child's condition. Researchers measured changes in children's bowel movements and stool consist…

This study looked at whether taking a laxative (polyethylene glycol 3350) both before and after surgery helps reduce discomfort during bowel movements after pelvic prolapse repair. 74 women having minimally invasive surgery were randomly assigned to take the laxative before and a…

This study tested whether a daily probiotic capsule (Bio-K+) could help adults with functional constipation have more complete and comfortable bowel movements. Over 12 weeks, 168 participants took either the probiotic or a placebo. Researchers tracked changes in bowel movement fr…

This study tested two acupuncture methods for chronic constipation in 60 adults. One group received warm needling (heated needles) at specific belly points, while the other got electroacupuncture (mild electric pulses). Both treatments were given three times a week for four weeks…

This completed trial tested whether a nerve stimulation treatment called PTNS can help children aged 8-18 with constipation caused by pelvic floor dyssynergia. Forty participants received either real PTNS or a sham (fake) treatment to see if it improves bowel function. The goal i…

This study tested whether abdominal massage can relieve constipation in people receiving hemodialysis. 49 adults took part. Researchers measured changes in constipation severity, quality of life, and stool consistency. The goal was to see if this simple, noninvasive technique cou…

This study tested whether daily probiotic supplements could improve constipation and weight gain in 30 children with cerebral palsy. Participants took either Lactobacillus reuteri or a prebiotic-enriched Lactobacillus rhamnosus for 28 days. Caregivers tracked bowel movements and …

This study looked at whether using a special footstool to change your sitting posture on the toilet can make bowel movements easier for people with a rectocele (a type of pelvic organ prolapse). Sixty participants tried the device and rated their straining on a 0-10 scale. The go…

This study looked at whether one session of abdominal massage can improve blood vessel stiffness, muscle oxygen levels, and exercise ability in adults with chronic constipation. About 30 people took part, with some getting a real massage and others resting instead. Researchers me…

This study tested whether a special 'constipation insole' based on reflexology could help ease constipation in 139 adults receiving palliative care. Participants in the experimental group walked with the insole for 20 minutes daily for four weeks, while the control group walked t…

This completed study tested two dietary supplements—a butyrate formulation and a butyrate plus polyphenol formulation—against a placebo in 143 adults with frequent gut issues. The goal was to see if these supplements improve gut health, reduce gut permeability, and ease digestive…

This study tested whether a daily probiotic supplement called Bacillus coagulans could improve constipation symptoms and gut bacteria in adults. Eighty participants took either the probiotic or a placebo for 12 weeks. The goal was to see if the probiotic could ease discomfort and…

This study tested a medicine called linaclotide in 19 babies and toddlers (6 months to under 2 years old) with long-term constipation. The goal was to see if it helps them have more bowel movements and softer stools, and to check for side effects. Children took the medicine as a …

This study tested whether a probiotic supplement called Notrande Shuhuajun can improve constipation in children aged 3 to 6. Over 100 kids took the supplement for two weeks, and researchers checked changes in gut bacteria and stool consistency. The goal was to see if the probioti…

This study tested whether ear massage can help bowel activity return faster after lower extremity surgery. Forty patients were split into two groups: one received standard care plus ear massage twice daily, the other standard care alone. Researchers measured when bowel sounds ret…

This small pilot study looked at whether treating constipation with a common laxative (lactulose) is practical for people with chronic kidney disease. Fourteen participants took lactulose daily for up to 6 weeks. The main goal was to see if people would stick with the treatment a…

This study looked at whether a simple abdominal massage given by a family caregiver can reduce stomach discomfort in people receiving palliative care. Fifty-six patients with constipation were split into two groups: one got the massage plus usual care, the other only usual care. …

This study tested whether electroacupuncture (a type of acupuncture with mild electric pulses) can safely relieve constipation caused by opioid painkillers in people with cancer. 92 patients took part in a single-blind trial where some received real electroacupuncture and others …

This study looked at whether adding fiber to liquid food given through a tube can prevent constipation caused by strong painkillers in ICU patients on breathing machines. Researchers compared fiber-enriched and fiber-free formulas in 80 adults. The goal was to see if fiber helps …

This study tested a new, smaller bowel irrigation device called Navina Mini in 27 children and teens aged 3 to 17 with bowel problems like severe constipation or leakage. The goal was to see if the device is safe, easy to use, and improves bowel emptying and satisfaction. Results…

This study looked at whether chewing sugar-free gum, drinking fennel tea, or drinking ginger tea could help women pass gas and feel more comfortable after a cesarean section. 128 women were randomly assigned to one of three groups and received the intervention at 6, 8, and 10 hou…

This study tested whether a telerehabilitation-based exercise program, along with a constipation education booklet, could reduce constipation symptoms and improve quality of life. Thirty-two adults with constipation took part. The approach used remote video sessions to guide exer…

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve chronic constipation. 90 adults with constipation took either the probiotic or a placebo for a period, and researchers tracked changes in stool form and gut bacteria. The goal was to see if t…

This study developed a risk assessment scale to identify hospitalized patients likely to develop constipation. Researchers enrolled 516 adults staying at least 4 days in the hospital. The goal is to catch high-risk individuals early and start prevention measures.

This study looked at whether magnetic stimulation of nerves in the lower back can change how the colon moves. It included 30 people: healthy volunteers, and patients with constipation or fecal incontinence. The goal was to understand the effect, not to treat the condition.

This study looked at how fermented dairy (like yogurt) and non-fermented dairy (like milk) affect bowel habits and thinking skills in healthy women who have bowel movements every other day or less. 96 women took part, eating 300g of dairy daily for 4 weeks. The goal was to see if…

This study looked at how the body processes TD-1211, a drug for opioid-induced constipation. Ten healthy men received a single dose of the drug with a radioactive tracer to track its absorption, distribution, and elimination. The goal was to understand the drug's behavior, not to…

This early-stage study tested a single dose of TD-1211, an experimental drug for constipation, in 47 healthy adults split into younger (18-45) and older (65-85) groups. Researchers measured how the body absorbs and eliminates the drug and checked for side effects. The goal was to…

This study tested a new, faster care plan for people with chronic constipation at a University of Michigan gastroenterology clinic. Researchers wanted to see how often doctors ordered special tests and pelvic floor therapy, and how satisfied patients were with their care. The stu…

This completed study looked at 60 people with obstructed defecation, a severe form of constipation. Researchers compared how well a noninvasive nerve stimulation treatment worked in obese versus non-obese participants. The goal was to see if body weight changes the treatment's ab…

This study reviewed scientific literature to compare manual (hand) versus automatic (machine) colon massage for people with chronic constipation. Researchers analyzed data from over 2,300 patients to see which method works better for improving bowel movements and quality of life.…

This study tested a new device called Fecobionics, which acts like artificial stool, to better understand and diagnose chronic constipation and fecal incontinence. Researchers studied 236 people, including patients and healthy volunteers, to see if the device can provide clearer …

This study looked at how the antibiotic metronidazole spreads into the intestinal tissue of 21 infants (ages 0-2) during planned bowel surgery. Researchers took blood and tissue samples at several time points to measure drug levels. The goal is to find the best dose to prevent in…

This study measured levels of the laxative PEG 3350 and its breakdown products in the blood and urine of 158 children who were already taking it, compared to children not taking it. The goal was simply to learn how the body processes this medicine, not to change any treatments. R…

This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one d…