Bowel dysfunction

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This trial compares two types of colon surgery for people with severe slow-transit constipation that hasn't improved with other treatments. About 252 adults will be randomly assigned to have either a total colectomy (removing the whole colon) or a subtotal colectomy (removing mos…

This study looks at whether measuring the rectal diameter with an ultrasound can accurately diagnose constipation in children aged 5-17. Researchers will compare ultrasound results with standard clinical criteria (Rome IV) in 130 children. If proven reliable, this simple, non-inv…

This study tests a new functional drink made with chicory inulin, B-vitamins, and vitamin D to see if it can improve constipation and overall well-being in people with Parkinson's disease. About 56 participants will drink either the active supplement or a placebo twice daily for …

This study tested whether adding pelvic floor muscle training to standard care (breathing exercises and lifestyle changes) helps women with chronic constipation. 28 women participated in an 8-week program. Researchers measured changes in bowel habits, muscle function, and quality…

This study tests whether linaclotide (Linzess) can improve bowel movement frequency in people with type 2 diabetes who have chronic constipation. About 23 participants will receive either the drug or a placebo for two weeks, then switch after a break. The goal is to see if the dr…

This study tests whether a probiotic supplement called iVS-1, containing Bifidobacterium adolescentis, can reduce moderate to severe digestive symptoms like bloating, gas, and belly pain. About 92 adults will take either the probiotic or a placebo for 6 weeks and report their sym…

This study was designed to see if the drug RELISTOR could help relieve constipation caused by opioid painkillers in people who had spinal fusion surgery. It planned to compare RELISTOR to standard laxatives in 40 patients. However, the study was withdrawn before enrolling anyone,…

This study tests whether adding two drugs (dexamethasone and dexmedetomidine) to a standard nerve block can extend pain relief after shoulder, foot, or ankle surgery. About 100 adults will be randomly assigned to get either the two-drug combo or dexamethasone alone. The goal is t…

This program allows people aged 12 and older with severe stomach or gut problems, like gastroparesis, to try domperidone when standard treatments have failed. The goal is to ease symptoms such as nausea, vomiting, and severe indigestion. The drug is not FDA-approved but is availa…

This study looks at whether using a 7-inch footstool while on the toilet can improve constipation symptoms. About 85 adults with chronic constipation will use either the real footstool or a very low sham stool for comparison. The goal is to see if the squatting position helps inc…

This study looks at whether taking probiotics after sleeve gastrectomy (a type of weight-loss surgery) can reduce constipation and other stomach issues. About 200 adults with severe obesity will take either a probiotic blend or a placebo for three months after surgery. Researcher…

This study is testing whether a daily supplement containing the B. longum probiotic can help adults who have infrequent bowel movements (less than 3 per week). Over 8 weeks, 80 participants will take either the probiotic or a placebo and track their bowel habits. The goal is to s…

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick …

This study looks at how straining affects people with bleeding hemorrhoids. Researchers will use surveys and a standard test called anorectal manometry to understand the link between pelvic floor problems and hemorrhoid symptoms. The goal is to help doctors give better treatment …

This study examines whether older adults with functional constipation are more likely to have a history of falls, reduced walking ability, and lower physical activity. Researchers will review medical records from 208 people aged 65 to 80. No new treatments or interventions are gi…

This study looks at whether a simple bedside device called the Rectal Expulsion Device (RED) can help doctors evaluate chronic constipation during a regular office visit. About 109 adults with chronic constipation will use the device and answer a survey. The goal is to see if thi…

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study explores why constipation is common in children with cerebral palsy and what factors might be involved, such as diet, physical activity, and caregiver stress. Researchers will observe 100 children aged 4 to 18 and their caregivers using questionnaires and diaries. No t…

This study interviews 20 people aged 16-25 who have had bladder or urinary problems since childhood and are now moving from pediatric to adult care. Researchers want to learn about their experiences, challenges, and opinions to make this transition smoother for others. No treatme…

This study checks if a Turkish translation of the Wexner Constipation Questionnaire works well for people with constipation. About 200 adults with functional constipation will fill out the questionnaire and a quality-of-life survey. Some will retake the Wexner after two weeks to …

This study explores whether chronic constipation is related to disorders of the sacroiliac joint, which is located in the pelvis. Researchers are testing 200 people with long-term constipation using electrotherapy and cupping to see if improving bowel function also affects joint …

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study uses insurance claims data to see if taking the constipation drug prucalopride during pregnancy is linked to birth defects or other problems for mothers and babies. Researchers will compare pregnant women who took prucalopride, those who took other constipation medicin…

This study is creating a registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect medical data, diet and lifestyle questionnaires, and biological samples to explore genetic, microbial, and environmental factors. The goal is t…

This study looks at whether a child's body position (sitting vs. lying down) changes the results of a test that measures anal and rectal pressures. Researchers will compare these positions in 120 children aged 5 to 18, some with constipation and some without. The goal is to find …