Tiny patients, big questions: antibiotic levels in infant bowel surgery

NCT ID NCT04299867

Completed Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how the antibiotic metronidazole spreads into the intestinal tissue of 21 infants (ages 0-2) during planned bowel surgery. Researchers took blood and tissue samples at several time points to measure drug levels. The goal is to find the best dose to prevent infections after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metronidazole
What this could lead to: If successful, this could help doctors give the right dose of metronidazole to infants during bowel surgery to prevent infections.
What could go wrong: This is a small, early study with only 21 infants, so results may not apply to all babies. It measures drug levels, not whether infections are actually prevented.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bowel dysfunction intestinal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BOWEL DYSFUNCTION

Contacts and locations

Locations

Duke University Health System

Durham, North Carolina, 27710, United States

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