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Fiber in feeding tubes may ease opioid constipation in ICU

NCT ID NCT07201428

Symptom relief Sponsor: Sisli Hamidiye Etfal Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether adding fiber to liquid food given through a tube can prevent constipation caused by strong painkillers in ICU patients on breathing machines. Researchers compared fiber-enriched and fiber-free formulas in 80 adults. The goal was to see if fiber helps patients have their first bowel movement sooner and reduces the need for enemas.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fiber-enriched enteral nutrition formula
What this could lead to
If it works, this could point toward a simple dietary change to prevent constipation in ICU patients on painkillers.
What could go wrong
This is a small, completed study with only 80 patients, so results may not apply to all ICU patients. Fiber may not help everyone and could cause bloating or discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

80 people

The number who actually took part.

Started

Dec 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patients over the age of 18 who are initiated on enteral nutrition and are on mechanical ventilation will be included in the study

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All patients over the age of 18 who are initiated on enteral nutrition and are on mechanical ventilation will be included in the study. Exclusion Criteria: * Pediatric and pregnant patients * Life expectancy less than 24 hours * Gastrointestinal surgery within the last week * Intra-abdominal pressure \> 15 mmHg * Shock requiring high vasopressor support * Contraindication to enteral nutrition * Intubation \>48 hours

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Conditions

The condition(s) this trial relates to.

constipation disorder opioid-induced constipation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Constipation, opioid-induced

Contacts and locations

Locations

  • Sisli Hamidiye Etfal Training Hospital

    Istanbul, 34371, Turkey (Türkiye)

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