Atherosclerosis

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This trial tests whether hydroxychloroquine, an anti-inflammatory drug, can reduce cardiovascular disease risk in people with chronic kidney disease (CKD). Participants with moderate-to-severe CKD will receive either hydroxychloroquine or a placebo for 18 months. Researchers will…

This study tested whether a drug called GM-CSF can improve symptoms and blood flow in people with peripheral artery disease (PAD), a condition where plaque narrows leg arteries, causing pain and limiting walking. 151 participants received either GM-CSF or a placebo for two 3-week…

This trial tests whether specially made cookies containing pumpkin seeds and walnuts can improve cholesterol levels in adults with atherosclerosis. For six weeks, one group eats a daily cookie while the other receives usual care alone. Researchers measure changes in LDL and HDL c…

This study tested whether a twice-yearly injection (inclisiran) lowers LDL cholesterol better than a daily pill (bempedoic acid) in 402 adults with heart disease who still have high cholesterol despite taking statins. Participants received either inclisiran or bempedoic acid on t…

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) within 6 hours after a stroke procedure (thrombectomy) could prevent early neurological worsening. 60 adults with large-vessel stroke were randomly assigned to receive either the drug plus standard…

This study tested a surgical technique called femoral tripod eversion for people with blocked leg arteries. 37 patients were followed for two years to check safety and effectiveness. The procedure aims to clear blockages without using synthetic materials. Early results suggest it…

This study tested whether ticagrelor, a newer antiplatelet drug, reduces heart muscle damage during a procedure called rotational atherectomy, which clears hardened arteries. 180 stable heart patients received either ticagrelor or standard clopidogrel before and after the procedu…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This completed study looked at two diabetes drugs, tirzepatide and sitagliptin, to see which one better prevents heart attacks, strokes, or death in people with type 2 diabetes and heart disease. Researchers analyzed data from over 49,000 patients. The goal was to learn how well …

This study tested a drug called olezarsen in 154 adults with high triglycerides (a type of blood fat) and either heart disease or very high triglycerides. Participants received injections of the drug or a placebo for up to 12 months. The main goal was to see if the drug could low…

This study tested whether a powerful blood thinner called tirofiban can improve recovery in people with a specific type of stroke called branch atheromatous disease (BAD). BAD strokes often get worse quickly and have few good treatments. The trial enrolled 516 adults within 48 ho…

This study tested a digital quality improvement program to help doctors better manage LDL (bad) cholesterol in patients with heart disease. Over 1,400 adults with established cardiovascular disease participated. The program used smartphone tools to improve treatment and follow gu…

This study looked at whether surgery helps people over 65 with mild primary hyperparathyroidism (high calcium levels) compared to just monitoring them. The goal was to see if surgery improves bone density and lowers fracture risk. A total of 102 participants were randomly assigne…

This pilot study tested whether delivering the drug paclitaxel directly to the leg artery during angioplasty could reduce the chance of the artery narrowing again. 27 adults with leg pain from blocked arteries took part. The main goal was to see if the drug helped keep the artery…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the leg arteries of people with peripheral artery disease (PAD). Twenty-four adults with PAD received either colchicine or a placebo. Researchers used special scans and blood tests to measure c…

This phase 2 trial tested olpasiran, an injectable drug, in 281 adults with high lipoprotein(a) – a genetic risk factor for heart disease. Participants received either olpasiran or a placebo. The main goal was to see how much the drug lowered Lp(a) levels after 36 weeks. Results …

This study looked at how well the ELUVIA drug-coated stent works in real-world patients with blocked arteries in the thigh or knee area. A total of 291 adults received the stent and were followed for two years. The main goal was to see if their quality of life and walking ability…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study tested a new drug called AZD0780 in 202 people with heart disease or related risks and high LDL cholesterol. Participants took either the drug or a placebo for 4 weeks, and researchers measured changes in blood pressure using a 24-hour monitor. The goal was to see if A…

This Phase 3 study tested a drug called olezarsen in 1,478 people with very high triglycerides (a type of blood fat) and either heart disease or a high risk for it. Participants received either olezarsen or a placebo as a shot under the skin. The main goal was to see if olezarsen…

This study looked at whether a once-weekly medicine called semaglutide (used for weight loss and diabetes) can lower the risk of heart attacks, strokes, and death in people with overweight or obesity. Researchers analyzed medical records of over 285,000 people in the US. The goal…

This study tested whether adding a fast-acting blood thinner (tirofiban) to standard aspirin can prevent strokes from getting worse in people with small artery blockages in the brain. About 970 adults aged 18-80 who had a mild stroke within the last 48 hours took part. The goal w…

This study tested a drug called inclisiran in 207 Chinese adults with moderately high bad cholesterol (LDL-C) who were not taking other cholesterol medicines. Participants received either inclisiran or a placebo for 6 months, followed by 6 months where everyone got the drug. The …

This completed study looked at 60 postmenopausal women with stable coronary artery disease. Researchers tested whether adding a daily 1000 mg quercetin supplement to standard atorvastatin treatment could affect levels of estrogen and a protein called SIRT1, which are linked to he…

This early-stage trial tested a new drug called AZD4144 in 29 people who have both heart disease and chronic kidney disease. The main goal was to see if the drug is safe and if it lowers certain markers of inflammation in the blood. The study compared the drug against a placebo o…

This study looked at whether the flu vaccine can reduce inflammation in people with stable coronary artery disease. Inflammation plays a key role in heart disease progression. The trial involved 47 adults aged 60 and older with stable heart disease, who received the flu vaccine e…

This study looked at 3048 adults with heart or blood vessel disease to see if lowering LDL ('bad') cholesterol to a very low level (below 55 mg/dL) is better than the standard target (below 70 mg/dL). Participants received either a statin alone or a statin plus ezetimibe. The goa…

This study tested whether adding a drug called inclisiran to standard care helps lower 'bad' LDL cholesterol more effectively in people who recently had a heart attack. About 400 participants received either the new care pathway including inclisiran or usual care alone. The goal …

This Phase 3 trial tested a daily pill combining two drugs, obicetrapib and ezetimibe, in 407 people with inherited high cholesterol or heart disease. Participants took the combination or a placebo on top of their usual cholesterol meds. The main goal was to see if the combo lowe…

This early-stage study tested a new drug called AZD4144 in 28 adults with obesity to see if it is safe and how it affects inflammation markers in the blood. Participants took either the drug or a placebo daily for a short time. The goal was to check for side effects and measure c…

This completed study looked at medical records from over 10,000 men with enlarged prostate (BPH) in the UK and China. Researchers wanted to see if men taking 5-alpha reductase inhibitors (drugs like finasteride) had fewer heart problems like heart attacks and strokes. The study c…

This study tested whether injecting donor stem cells into the leg muscles before amputation could prevent wound problems and reduce the need for more amputations. 81 people scheduled for leg amputation due to poor blood flow took part. The main goal was to check safety, not yet t…

This study tested a new drug called obicetrapib in over 2,500 people with high cholesterol that wasn't well controlled by their current treatments. Participants took either a 10 mg obicetrapib pill or a placebo daily for about 6 months. The main goal was to see if obicetrapib cou…

This study tested whether adding ezetimibe to atorvastatin (a common cholesterol drug) works better than atorvastatin alone in people at very high risk for heart attacks or strokes. Researchers enrolled 137 adults with atherosclerotic cardiovascular disease and measured how much …

This study tests whether a simpler device called pOpmètre can accurately measure arterial stiffness in children aged 4 to 8. Arterial stiffness is an important sign of heart and blood vessel health. The standard device, Sphygmocor, is harder to use in children. If pOpmètre works …

This study compared two types of heart scans—CT and PET—to see if CT can measure blood flow to the heart as accurately as PET, which is the current gold standard. Researchers enrolled 20 adults with suspected coronary artery disease. Each participant received both a CT scan and a…

This study tested whether giving pregnant women in India, Guatemala, Peru, and Rwanda a clean-burning liquefied petroleum gas (LPG) stove and free fuel for 18 months could improve health outcomes for their babies. Over 3,600 households participated, with half receiving the LPG st…

This study tested whether intensive, face-to-face coaching on lifestyle changes and medication adherence could reduce strokes and mini-strokes in 120 high-risk Native American adults in Wisconsin. Participants received either intensive coaching or standard care, with regular heal…

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

This study looks at two medicines, alirocumab and inclisiran, that help lower bad cholesterol (LDL-C) in people with heart disease. Researchers will use real-world data from about 124 patients to see which drug reduces cholesterol more over time. The goal is to understand how the…

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This study aimed to find new gene changes that cause rare lipid disorders. Researchers used advanced genetic testing to look at many genes at once in 140 people and their relatives. The goal was to discover causes that older methods missed.

This study aims to create a smart computer program that helps doctors better understand the sounds from a handheld device used to check blood flow in arteries. Many doctors lack formal training in using this device, which can lead to missed or wrong diagnoses. The study will coll…

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cel…

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This completed Phase 4 trial looked at how evolocumab (Repatha), a cholesterol-lowering drug, affects markers of inflammation and blood clotting in 41 people with type 2 diabetes and heart disease. Participants received either evolocumab or a placebo injection every 4 weeks for 1…

This completed study followed 1868 patients with high cholesterol to see how inclisiran (Leqvio®) and other cholesterol-lowering treatments work in real-world medical practice. Researchers tracked heart events, medication use, and lab results without assigning any treatments. The…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This study examined 200 adults who had surgery to remove plaque from their carotid arteries. Researchers identified bacteria living inside the plaques and tracked whether certain types were linked to later strokes, re-narrowing of the artery, or death. The goal was to learn which…

This study looked at 86 people with very high or very low cholesterol efflux—a measure of how well the body removes cholesterol from cells. Researchers analyzed their genes, proteins, and lipids to find clues that could lead to new ways to prevent or reverse heart disease. The go…

This study looked at a molecule called microRNA-210 in 230 people with peripheral artery disease (PAD), a condition where leg arteries become blocked. Researchers measured its levels and linked them to oxidative stress and walking ability. The goal was to understand how this mole…

This study looked at 91 Chinese patients with atrial fibrillation who had a stroke while taking blood thinners (NOACs). The goal was to understand why these strokes happen and whether not taking the medication as prescribed played a role. Researchers hope this knowledge will help…

This study surveyed 608 heart and kidney doctors to understand their awareness and use of a blood test called hsCRP, which measures inflammation. The goal was to learn what doctors think about inflammation's role in treating patients with heart disease, kidney disease, or heart f…

This study looked at 100 people with gum disease, some also with obesity, to see how non-surgical gum cleaning affects the body's immune system. Researchers measured changes in inflammation and immune cells before and after treatment, comparing men and women. The goal was to find…

This study looked at 1,655 people who had a heart attack or unstable angina (acute coronary syndrome) to create a personalized risk model. Researchers used medical tests, genetic information, and other health data to predict who might have worse outcomes or complications from tre…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study surveyed 1,500 Chinese heart and kidney specialists to understand their awareness and perceptions of systemic inflammation in patients with both atherosclerotic cardiovascular disease and chronic kidney disease. The goal was to learn how doctors currently identify and …

This study looked at the gut bacteria and bile acids of 80 people — half with coronary artery disease and half healthy. Researchers wanted to see if differences in these gut factors might be linked to heart disease. The goal is to better understand how the gut influences heart he…

This completed study examined why people with rheumatoid arthritis (RA) and lupus have a higher risk of heart attacks. Researchers collected blood samples from 176 participants and tested how statins and adenosine A2A receptor agonists affected cholesterol balance in cells. The g…

This study looked at nearly 40,000 people with a history of heart disease caused by clogged arteries. The goal was to measure their levels of lipoprotein(a), a fatty substance that can increase heart risk. Researchers wanted to see how these levels vary by age, sex, race, and reg…

This study looked at whether vitamin D levels in the blood are related to early signs of artery hardening (atherosclerosis) in people on dialysis. Researchers measured vitamin D and used ultrasound to check artery thickness in 90 adults with kidney failure. The goal was to see if…

This study tested whether taking a high-dose fish oil supplement (E-EPA) for one month changes how LDL ('bad' cholesterol) clumps together in 68 healthy adults. Researchers measured blood fats and LDL stickiness before, during, and after the supplement period. The goal was to und…

This completed study looked at 357 healthy adults aged 35-65 to understand how excess belly fat relates to the buildup of fatty plaque in arteries, a key cause of heart attacks. Using MRI and CT scans, researchers measured abdominal fat and artery wall thickness. The goal was to …

This study checked if newer psoriasis drugs (IL17/23 inhibitors) also improve artery stiffness, a sign of heart disease. Researchers followed 66 people with moderate-to-severe psoriasis for a year, measuring pulse wave velocity (PWV) and other markers. The goal was to see if thes…

This study followed 320 people with atherosclerosis for 10 years to see how the disease changes over time. Researchers used ultrasound scans and genetic tests to track artery health and predict heart attacks, strokes, and leg problems. The goal was to better understand why athero…