Fish oil pill may make 'bad' cholesterol less dangerous, study finds

NCT ID NCT04152291

Completed Knowledge-focused Sponsor: Wihuri Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether taking a high-dose fish oil supplement (E-EPA) for one month changes how LDL ('bad' cholesterol) clumps together in 68 healthy adults. Researchers measured blood fats and LDL stickiness before, during, and after the supplement period. The goal was to understand how E-EPA might lower heart disease risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ethyl eicosapentaenoic acid (E-EPA, also known as icosapent ethyl)
What this could lead to: If it works, this could help explain how E-EPA lowers heart disease risk by making LDL particles less sticky.
What could go wrong: This is a small, early-stage study in healthy people, not patients. Results may not apply to those with high cholesterol or heart disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerosis cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHEROSCLEROSIS CARDIOVASCULAR DISEASES LOW-DENSITY LIPOPROTEIN LIPID COMPOSITION LOW-DENSITY LIPOPROTEINS AGGREGATION SUSCEPTIBILITY

Contacts and locations

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Locations

Wihuri Research Institute

Helsinki, Finland

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