University Of California, Irvine

This study compares a short course of antibiotics (48 hours after infection control) to a standard 7-day course for people with severe flesh-eating infections (NSTI). About 50 adults will participate to see if the shorter treatment is just as safe and reduces hospital complicatio…

This study tests a combination of drugs (cabozantinib, ipilimumab, nivolumab) and a procedure called TACE in people with liver cancer that cannot be removed by surgery or treated with a transplant. The goal is to see if this approach can stop the cancer from growing for at least …

This early-phase trial is testing whether adjusting chemotherapy based on how the tumor responds can help more people with stomach or gastroesophageal junction cancer complete their treatment and have surgery. About 20 adults with stage IB to III disease will receive a personaliz…

This early-phase study tests whether adding the cholesterol-lowering drug pitavastatin to standard chemotherapy (gemcitabine and nab-paclitaxel) can help control advanced pancreatic cancer that cannot be removed by surgery. About 18 adults whose cancer has not worsened on initial…

This study tests whether a combination of two chemotherapy drugs (trifluridine/tipiracil and irinotecan) can clear leftover cancer DNA from the blood of people with colon cancer after surgery. About 22 adults whose blood still shows signs of cancer after standard treatment will r…

This study is testing whether a lower dose of radiation can still control HPV-positive throat cancer while reducing side effects. About 111 people with this type of cancer will receive the reduced radiation and be followed for at least two years. The goal is to see if the cancer …

This study tests whether giving two drugs together after surgery can keep bladder cancer from returning in patients at high risk. About 23 adults who have had their bladder or part of their urinary tract removed will receive sacituzumab govitecan and nivolumab. The goal is to see…

This study tests a modified version of sleeve gastrectomy (a common weight-loss surgery) to see if it can reduce acid reflux, a frequent side effect. About 44 adults with obesity and GERD will be randomly assigned to the standard or modified surgery. The main goal is to measure c…

This study tests whether combining two drugs—cyclophosphamide and pembrolizumab—can shrink tumors in people with advanced melanoma that no longer responds to standard immunotherapy. About 14 adults with stage III or IV melanoma will receive the combination. The goal is to see if …

This study tests a personalized approach to stem cell transplants for adults with blood cancers like leukemia and lymphoma. The chemotherapy and radiation doses are adjusted based on each patient's risk factors to try to improve outcomes. The goal is to see if this tailored plan …

This study tests whether Nelfinavir, a drug originally used for HIV, can improve anemia in people with myelofibrosis, a rare bone marrow cancer. The drug aims to help the body deliver iron to the bone marrow to make more red blood cells. About 10 adults with low hemoglobin will t…

This study tests whether adding weight-loss medications (topiramate, phentermine, or both) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and regained a…

This study looks at whether taking the blood thinner Lovenox three times a day, instead of the usual twice a day, can better prevent blood clots in pregnant women at high risk. Many pregnant women do not get enough protection from the standard twice-daily dose due to changes in t…

This study looks at whether giving thyroid hormone (levothyroxine) to people on dialysis who have slightly high TSH levels can improve their quality of life, physical strength, and heart health. About 336 adults on hemodialysis will receive either the hormone or a placebo for a y…

This study tests a combination of three drugs (anastrozole, fulvestrant, and abemaciclib) in 20 people with a common type of advanced breast cancer (HR-positive, HER2-negative). The goal is to see how well the treatment shrinks or controls the cancer. Participants either have new…

This study compares a special MRI scan (mpMRI) to the standard surgical biopsy (TURBT) for diagnosing muscle-invasive bladder cancer. Researchers want to see if the MRI can accurately detect cancer invasion into the bladder muscle, which could help some patients avoid an invasive…

This study is testing whether a non-contact camera system can accurately assess burn wound severity and predict healing potential. Researchers will enroll 200 people with burn injuries and use modulated imaging and laser speckle imaging to measure blood flow and tissue health. Th…

This study tests a new, non-invasive device that uses LED lights to measure how light scatters and is absorbed by the eardrum and middle ear. The goal is to see if this method can more accurately diagnose middle ear infections compared to the standard visual exam. The study will …

This study tests a therapy called Positive Affect Therapy (PAT) to see if it can prevent depression in teens aged 12-16 who have experienced two or more adverse childhood events (like abuse or neglect). The therapy focuses on increasing positive feelings and reward sensitivity. R…

This study tests a program to help prevent cervical cancer in women who have both HPV and HIV. The program includes HPV screening, nutritional support, and mental health help delivered by community health workers. Researchers will enroll 420 women in India to see if this approach…

This study tests a program called GRIT, where community health workers coach teens (ages 11-14) and their families on self-regulation skills over six video sessions. The goal is to prevent early, regular use of alcohol and cannabis in youth who have experienced four or more adver…

This study looks at whether eating solid food before a type of hand surgery called WALANT (where you're awake and only numbed locally) can help lower anxiety and nausea. About 134 adults will be randomly assigned to either eat or fast before their procedure. Researchers will comp…

This study looks at whether acupuncture can make opioid painkillers work better for people with fibromyalgia. About 45 adults who already take daily opioids for fibromyalgia pain will receive either real acupuncture or a sham (fake) version. Researchers will measure how much pain…

This study tests a non-hormonal laser treatment for vaginal dryness, burning, and pain during sex caused by menopause. About 50 postmenopausal women will either receive the real laser or a sham (fake) treatment. Researchers will use a special camera to measure changes in vaginal …

This early study is testing whether a new oxygen-delivery system using tiny bubbles (micro/nanobubbles) can safely help heal different types of wounds, from cuts and burns to diabetic ulcers. About 40 adults with open wounds will receive either the oxygen bubble treatment or a st…

This pilot study will test a brief cognitive-behavioral resilience training program for 60 adults recently released on parole. The goal is to see if the program is practical and helpful in reducing adjustment difficulties and improving well-being. Participants will complete quest…

This study tests whether a hands-off therapy called energy healing can reduce pain and change brain activity in women with fibromyalgia. 25 participants will receive either real or sham (fake) energy healing while their brains are scanned with fMRI. The goal is to see if real ene…

This study tests a mobile app called L-WebTIPS, designed to help Latinx children ages 2-7 and their families prepare for and recover from outpatient surgery. The app provides coping skills and information in a culturally adapted format. Researchers will measure whether it reduces…

This study tests whether a combination of two medications, nortriptyline and topiramate, can improve symptoms of Meniere's disease, a chronic inner ear disorder that causes vertigo, hearing loss, and tinnitus. The trial will involve 40 adults with active Meniere's disease. Partic…

This study compares two medications, Sugammadex and a combination of Neostigmine with Glycopyrrolate, to see which one helps bowel function return sooner after colorectal surgery. About 128 adults having laparoscopic bowel resection will be randomly assigned to receive one of the…

This study tests N-acetylcysteine (N-AC), a supplement, in 27 adults with certain blood cancers (myeloproliferative neoplasms). The goal is to find the best dose that reduces symptoms like fatigue and pain while being safe. Participants continue their usual treatments during the …

This study is testing whether nicotine gum can reverse age-related hearing problems. Researchers will give nicotine gum to healthy adults aged 18 to 85 and measure their hearing and brain responses. The goal is to see if nicotine can improve how the brain processes sound, which c…

This study tests whether using a special dye (ICG) during robotic prostate surgery helps preserve sexual function and bladder control in men with prostate cancer. About 400 men will take part, and the main goal is to see how many need little to no pads for urine leakage three mon…

This study looks at whether music therapy is a practical way to improve quality of life for teens and adults (14+) with sickle cell disease. 90 participants will be split into three groups: in-person music therapy, a mix of in-person and virtual music therapy, or virtual health e…

This small study at UC Irvine is testing whether core shamanism—a traditional healing practice—can reduce pain and other symptoms in women with fibromyalgia. About 25 participants will attend up to 5 shamanic sessions while researchers track pain levels, heart rate, breathing, an…

This study tests a mobile health app designed to help cancer patients remember to take their oral medications and report symptoms. Researchers will enroll 35 English- or Spanish-speaking adults with cancer who are starting or recently started oral anticancer therapy. The goal is …

This study looks at whether Reiki, a non-invasive therapy where a practitioner lightly places hands near the body, can help adults with cancer who feel very tired from immunotherapy. Twelve participants will either receive six weekly Reiki sessions or wait, then switch. Researche…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This early-phase study tests whether a special dye called pafolacianine (CYTALUX) can help surgeons see cancerous lesions during surgery for gastrointestinal cancer that has spread to the lining of the abdomen. Ten adults with this condition will receive the dye before surgery, a…

This study looks at the gut microbiome (bacteria in your digestive system) of people with advanced non-small cell lung cancer. Researchers want to see if the types and variety of gut bacteria are linked to how well cancer treatments work and what side effects occur. About 82 part…

This study looks at how two common mouthwashes (Listerine and Lumineux Oral Essentials) affect bacteria and three viruses in the mouth and gut. About 200 healthy adults aged 18-25 will rinse twice daily for 180 days. Researchers will collect mouth swabs and stool samples to measu…

This study looks at whether taking a blood sample from the vein that drains directly from a liver or pancreas tumor gives more useful genetic information than a standard arm vein sample. About 15 adults scheduled for a biopsy will provide both samples, and researchers will compar…

This study is testing a new way to measure oral health using photographs and imaging software instead of just traditional exams. About 275 adults will use a toothpaste or mouthwash for up to 6 months while researchers track plaque, gum health, and saliva. The goal is to find bett…

This study looks at whether a person's personality traits are linked to how consistently they take their daily cancer medication for chronic myeloid leukemia (CML). Researchers will ask 75 adults with CML to fill out questionnaires about their personality, medication habits, and …

This study looks at how extra blood vessel growth (angiogenesis) contributes to skin diseases like rosacea, psoriasis, scars, and certain birthmarks. Researchers will analyze skin samples from 85 volunteers aged 16 and older to find markers linked to these conditions. The goal is…

This study is creating new ways to test exercise in children with cystic fibrosis, sickle cell disease, or long COVID. Current tests are designed for healthy athletes and don't work well for kids with these conditions. Researchers will track about 240 children over several years …

This study looks at how well blood vessels work in men aged 30-50 with erectile dysfunction or low testosterone. Researchers will use a device called EndoPAT to measure vessel function before and 3-6 months after starting daily low-dose ED medication or testosterone therapy. The …

This study looks at whether using video calls (telemedicine) is a good way to educate and counsel people who are thinking about donating a kidney while they are still alive. Researchers want to see if this approach helps donors make better decisions and stay engaged in the proces…

This study aims to understand why some people experience changes in thinking and memory as they get older. Researchers will use brain scans (MRI and PET) and memory tests to detect early signs of decline in 300 healthy adults aged 60 and older. The goal is to find better ways to …

This study looks at how stress changes memory in teenagers who have experienced maltreatment compared to those who haven't. Researchers will have 400 teens (ages 12-18) do activities that are either stressful or not, then test their memory for images and events over a month. The …

This study looks at how ibogaine, a plant-based compound, affects brain activity and reduces cravings in people with moderate to severe opioid use disorder. Twenty adults who are already scheduled to receive ibogaine treatment at a licensed clinic in Mexico will undergo brain sca…

This study tests three non-invasive imaging devices to see how well they measure skin blood flow. About 150 adults will have a blood pressure cuff on their arm to temporarily stop blood flow while the devices take pictures. The goal is to see if these tools can detect changes in …