University Of California, Irvine

This small study looked at whether a 5-day fasting-mimicking diet (a special low-calorie meal plan) is practical for Asian Americans with prediabetes. Thirty participants tried one cycle of the diet and had their blood sugar and physical measurements checked before and after. The…

This early-phase study tested adding the cholesterol drug pitavastatin to the standard cancer drug venetoclax for people with chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML). The main goal was to find a safe dose and check for side effects. Only 6 people took p…

This study compared two educational programs designed to help Hispanic adults with uncontrolled high blood pressure stick to their medication routine. Over 500 participants took part, and researchers measured how well they took their pills using special bottle caps that record ea…

This study looked at whether drinking artificially sweetened diet beverages affects blood sugar control in adults with type 2 diabetes. About 181 participants were randomly assigned to drink either their usual diet beverage or plain water daily for 24 weeks. The main goal was to …

This study tested whether a special cleaning routine (decolonization) could prevent MRSA infections in people carrying the superbug after hospital discharge. Over 2,100 adults with recent MRSA-positive tests were randomly assigned to either the cleaning routine or standard educat…

This early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with metastatic colorectal cancer that had stopped responding to standard treatments. The main goal was to find the safest dose and check for side effects. The study is complete and h…

This study tested whether special light-based cameras and sensors can detect and diagnose mouth diseases, including cancer, without needing a biopsy. Over 1,000 adults with various oral conditions and healthy volunteers had their mouths imaged with harmless light. The goal was to…

This study tested a new therapy that combines brain-computer interface (BCI) technology with functional electrical stimulation (FES) to help stroke survivors improve their walking. The therapy uses brain signals to control mild electrical pulses that activate foot muscles, aiming…

This study tested a culturally relevant program to reduce stress and improve quality of life for Spanish-speaking Latino parents caring for a child with cancer. 33 caregivers participated, and the program focused on providing support and coping strategies. The goal was to see if …

This study looked at whether adding extra arm exercises to standard rehab helps stroke survivors recover arm movement. It compared a custom exercise program designed by a therapist to using a movable wheelchair arm rest that moves the arm back and forth. 35 people who had a strok…

This study tested whether giving Botox in one spot inside the bladder works as well as the usual ten spots for treating overactive bladder. 116 women with urgency or leakage were randomly assigned to one injection or ten. The main goal was to see if symptoms improved and if patie…

This study tested whether two combinations of migraine medications could help people with moderate to severe tinnitus. 78 adults took part and were compared to a placebo group. The goal was to see if these drugs could reduce the negative impact of tinnitus on daily life, such as …

This study tested whether adding trained therapy dogs to standard social skills training could help children with ADHD. 39 kids took part, and researchers measured changes in attention, hyperactivity, and social behavior. The goal was to see if the dog-assisted approach improves …

This study tested a mobile app called Pain Buddy in 206 children aged 8-18 receiving outpatient chemotherapy for cancer. The app helped children report their pain, symptoms, and quality of life daily from home. The goal was to give doctors and families better information to manag…

This study tested whether using virtual reality (VR) during a knee pain treatment called genicular nerve radiofrequency ablation could reduce pain and improve patient satisfaction. Forty adults who were already scheduled for the procedure took part. The results showed that VR hel…

This study tested whether a medicine called dexmedetomidine (Precedex) can help control pain in adults with three or more broken ribs. The goal was to lower pain scores and reduce the need for strong opioid painkillers. 41 ICU patients took part, and researchers tracked their pai…

This study tested whether taking tadalafil (Cialis), tamsulosin (Flomax), or both before kidney stone surgery helps doctors place a larger tube (access sheath) to remove stones more easily. 220 adults having surgery for kidney stones were randomly assigned to one of four groups: …

This study tested a personalized internet-based program called WebTIPS to help children ages 1-12 feel less anxious before and after surgery. Over 1,200 parent-child pairs took part, with some using WebTIPS and others receiving standard online information. The goal was to see if …

This study looked at how stress and race affect eating and physical activity in teenage girls. Researchers compared African-American, Caucasian, and Hispanic/Latina girls aged 13-17. They measured food intake after stress and non-stress sessions, along with body mass index and ac…

This study tested a program to help more people at high risk for lung cancer get a low-dose CT scan, which can catch the disease early and save lives. The program included notifying doctors, educating patients, offering financial help, and reminding patients to talk about screeni…

This study looked at whether watching short science videos can change how adults with anxiety think about psychological therapy. 262 participants watched educational videos and filled out surveys about their beliefs and expectations. The goal was to see if scientific information …

This study looked at how healthy children and young adults (ages 7-35) respond to different types of exercise, like biking and treadmill walking. Researchers measured their oxygen use and heart rate during exercise. The goal is to create better fitness tests and personalized exer…

This study tested whether a program designed to reduce risky behaviors in African-American teens actually changes brain activity. Researchers used brain scans to see how the program affects emotional and cognitive control regions. The goal is to better understand how to prevent d…

This study tested a program to help Hispanic/Latinx patients get screened for lung cancer. 60 eligible adults received either extra support (education, reminders, and financial help) or usual care. The goal was to see if the program increased the number of people who got a low-do…