University Of California, Irvine

This is a small, early-stage study to see if it's safe and practical to combine a targeted, high-dose radiation treatment with an immunotherapy drug (pembrolizumab) for people with advanced soft-tissue sarcoma that has spread or come back. The goal is to see if this two-part appr…

This study is testing whether combining two drugs, CPX-351 and glasdegib, is effective for adults with specific, hard-to-treat forms of acute myeloid leukemia (AML) who have not yet received treatment. The main goal is to see how many patients are still in remission and event-fre…

This study aimed to see if giving calcium directly into the bloodstream during major blood transfusions helps trauma patients who are bleeding heavily. It planned to compare giving calcium right away to the usual method of checking blood levels first. The goal was to see if early…

This study aims to understand how well women stick to different vaginal estrogen treatments (cream, tablets, or ring) to prevent recurrent urinary tract infections after menopause. Researchers will also examine changes in vaginal tissue and bacteria before and after treatment. Th…

This study is testing if giving caffeine to very premature babies for a few extra weeks helps them learn to feed by mouth faster. It involves 80 infants who are already stable enough to stop caffeine. Researchers will compare how quickly babies in two groups reach full feeding an…

This study is testing whether a private, peer-led Facebook group can encourage more people with opioid addiction to ask for and start medication treatment. About 640 adults with moderate-to-severe opioid use disorder who are not currently on medication will be randomly placed int…

This early-stage study is testing a new type of cell therapy for people with advanced non-small cell lung cancer that has spread and no longer responds to standard immunotherapy. Researchers are giving patients specially modified immune cells (called NK cells) taken from umbilica…

This trial is testing a two-step treatment for stomach or gastroesophageal cancer that has spread to the abdominal lining. First, patients receive standard chemotherapy. If the cancer hasn't spread to other organs, they then receive a second type of chemotherapy delivered directl…

This study aims to develop better, non-invasive ways to detect and understand oral diseases using light-based imaging. Researchers will scan the mouths of 2,500 people with various conditions (like gum disease, sores, or cancer) and healthy volunteers. They will compare these new…

This study is testing a community-based program to help prevent high blood pressure and heart disease in Latino and Vietnamese families in Santa Ana, California. For three years, some families will work with community health workers who provide personalized coaching, educational …

This study tests a program designed to help more Hispanic patients get screened for lung cancer. It works by reminding doctors, educating patients, helping with costs, and prompting discussions during doctor visits. The goal is to see if this approach gets more eligible patients …

This study is testing whether a form of acupuncture that uses a mild electrical current can help manage common symptoms experienced by cancer patients and survivors. The goal is to see if it can reduce fatigue, memory problems, insomnia, and distress, and improve quality of life.…

This study is testing a special support program for teens and young adults who are at risk for developing psychosis and are also having suicidal thoughts. The program, called the Youth-Nominated Support Team (YST), works by training and guiding a young person's chosen friends and…

This study is testing whether two different combinations of migraine medications can help people with recent-onset ringing in the ears (tinnitus). 100 participants will be randomly assigned to take one of the two drug combinations for 8 weeks to see if it reduces the distress and…

This study is testing a Spanish-language digital therapy program to help Latino patients manage depression and anxiety. Researchers are comparing two approaches: a self-guided version and one with extra support. The goal is to make mental health care more accessible in primary ca…

This small pilot study is testing whether electroacupuncture—a form of acupuncture with mild electrical stimulation—is a practical and helpful way to manage difficult symptoms after a major abdominal cancer surgery. The study will enroll 20 patients who have undergone this specif…

This study is testing whether listening to relaxation music can help reduce chronic pain for people with irritable bowel syndrome (IBS), Crohn's disease, or colitis. It involves 120 adults in the US who have had significant gut-related pain for at least three months and also expe…

This study tests different ways to help cancer patients struggling with the high costs of care and basic needs like food and housing. It compares three approaches: one-on-one financial counseling, providing self-help resource lists, and standard care. The goal is to see which met…

This study is exploring whether listening to jazz music, sometimes combined with mindful listening techniques, can help reduce pain for people with chronic pain conditions. About 90 adults with chronic pain will be assigned to either listen to jazz daily for four weeks, listen mi…

This study is testing if the medication mirtazapine can help newly diagnosed brain cancer patients who are feeling depressed and suffering from severe nausea and vomiting caused by their chemotherapy. Researchers will give the drug to about 36 depressed patients for eight weeks t…

This study aimed to compare two lidocaine treatments for muscle pain in the neck or back. Emergency room patients would have received either a lidocaine injection directly into the painful muscle knot or worn a lidocaine patch on the skin. The goal was to see which method provide…

This study is testing if adding a new FDA-approved, non-opioid pain pill called suzetrigine to standard pain care works better for adults with multiple broken ribs. Researchers want to see if it improves pain control and helps patients use fewer opioid painkillers, which can be a…

This study is testing whether starting pelvic floor physical therapy before prostate surgery helps men regain bladder control faster. Researchers are comparing men who start therapy before surgery to those who start after, which is current practice. The goal is to see if this sim…

This study aims to better understand how a rare muscle-wasting disease called sporadic inclusion body myositis (sIBM) progresses over time. Researchers will observe 150 adults with sIBM for two years, tracking their physical function, strength, and breathing. The goal is to learn…

This study investigates whether watching educational science videos can influence people's beliefs about psychological therapy for anxiety. Researchers are testing two different types of educational content with 300 adults who experience anxiety. Participants watch videos for 30 …

This study aims to understand if emphasizing certain words in the instructions for mental health questionnaires changes how people answer them. It involves 200 U.S. adults who have been treated for depression or anxiety in the past year. Participants will complete the same questi…