University Of California, Irvine

This early-phase study tested whether combining the immunotherapy drug pembrolizumab with precise, high-dose radiation (SBRT) is feasible for people with advanced soft-tissue sarcoma that has spread or cannot be removed by surgery. Nine participants were enrolled to see if they c…

This study tests a treatment for stomach cancer that has spread to the lining of the abdomen. It combines standard chemotherapy given through a vein with chemotherapy delivered directly into the belly. The goal is to see if this approach helps control the cancer and improves surv…

This study looks at how well women with low estrogen (like after menopause) stick to using vaginal estrogen cream, tablets, or a ring to prevent repeat urinary tract infections. Researchers will also check changes in vaginal tissue and natural bacteria. About 111 women will be ra…

This study tests a combination of two drugs, CPX-351 and glasdegib, in adults with a specific type of acute myeloid leukemia (AML) that is either linked to a prior bone marrow disorder or caused by previous cancer treatment. The goal is to see if the combo helps patients stay in …

This early-phase study tests a new treatment for people with advanced non-small cell lung cancer that no longer responds to standard immunotherapy. The treatment uses immune cells from donated umbilical cord blood that are genetically modified to better recognize and attack cance…

This study tests a culturally tailored program to help Latinx and Vietnamese families in Santa Ana, CA, improve their heart health and prevent high blood pressure. About 483 participants will work with community health workers to set healthy goals, improve communication with doct…

This study looks at whether helping cancer patients with financial and social needs (like food, housing, or transportation) can improve their treatment and well-being. About 91 newly diagnosed cancer patients who report money problems will receive either one-on-one financial coun…

This study aimed to see if lidocaine injections work better than lidocaine patches for muscle pain in the neck and back. It was designed for adults coming to the emergency department with this type of pain. However, the study was withdrawn before any patients were enrolled, so no…

This study looks at whether doing pelvic floor physical therapy before prostate surgery (HoLEP) can help men regain bladder control faster after the operation. About 72 men who are already scheduled for HoLEP will be split into two groups: one starts therapy before surgery and co…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce common symptoms like memory problems, fatigue, insomnia, and anxiety in cancer patients and survivors. About 70 participants will receive either real or sham electroacupunct…

This study looks at whether giving caffeine to preterm babies for a longer time helps them learn to bottle-feed or breastfeed fully. About 80 infants born at 32 weeks or earlier will take part. The goal is to see if extended caffeine use reduces the time to reach full oral feedin…

This study tests whether migraine medications can reduce the impact of sudden tinnitus (ringing in the ears) in 100 adults aged 25 to 85. Participants will take the drugs and report changes in how much tinnitus bothers them, using a standard questionnaire. Brain scans will also l…

This study tests whether listening to relaxation music can reduce chronic pain in people with IBS, Crohn's disease, or colitis. Researchers will enroll 120 adults in the U.S. who have moderate to severe pain and anxiety. The goal is to find a safe, non-addictive way to manage pai…

This study explores whether listening to jazz music combined with mindfulness exercises can reduce chronic pain and anxiety in adults. About 90 participants with chronic pain and moderate anxiety will try this non-drug approach. The goal is to find a safer, non-addictive way to m…

This study looks at whether mirtazapine, an antidepressant, can help reduce depression, nausea, and vomiting in people with a type of brain cancer (glioma) who are taking the chemotherapy drug temozolomide. About 120 adults with newly diagnosed glioma and depression will take mir…

This study looks at whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help manage symptoms like pain, nausea, and trouble sleeping after a major cancer surgery. The researchers will test this in 20 people who have had cytoreductive surgery and hea…

This study looks at whether a digital cognitive behavioral therapy program (SilverCloud) can help Spanish-speaking adults with depression or anxiety. 426 patients will either use the program on their own or with extra support. The goal is to see if this approach improves symptoms…

This study tests whether adding suzetrigine to standard pain treatments helps adults with multiple broken ribs feel less pain and use fewer opioids. About 80 people will take part. The goal is to improve breathing and reduce hospital stays.

This study looks at whether emphasizing certain words in a mental health questionnaire changes how people respond. Researchers will ask 200 adults with depression or anxiety to fill out the same survey twice in one day, with different instructions. The goal is to understand if th…

This study adapts a program called Youth-Nominated Support Team (YST) for suicidal adolescents who are at clinical high risk for psychosis. Researchers will test whether involving a support team chosen by the teen can improve social connectedness, hope, and treatment engagement. …

This study was designed to see if giving calcium immediately to trauma patients receiving large blood transfusions could reduce the amount of blood products needed and improve survival. Calcium helps blood clot, which may help stop bleeding. However, the trial was withdrawn befor…

This study follows 150 adults with sporadic inclusion body myositis (sIBM), a rare muscle disease, for two years. Researchers will measure muscle strength, breathing, and swallowing every six months to understand how the disease progresses. No treatments are tested—the goal is to…

This study looks at whether an online support program called HOPE can help people with opioid use disorder learn about and ask for medication treatment. Researchers will track how many participants request information or help scheduling an appointment. The study involves 640 adul…