University Of California, Irvine

Researchers are testing whether GammaTile, a collagen tile embedded with radioactive cesium-131 seeds, can be safely placed in the brain after surgery for malignant glioma. The trial enrolls elderly or frail patients with newly diagnosed or recurrent tumors. The main goals are to…

Researchers are testing whether adding epcoritamab can help high-risk chronic lymphocytic leukemia (CLL) patients who are already taking a BTK inhibitor clear remaining cancer cells. The trial enrolls 24 adults with CLL and specific risk factors such as a 17p deletion, TP53 mutat…

This study tests whether giving two immunotherapy drugs (fianlimab and cemiplimab) before surgery can shrink melanoma tumors in people with stage IIIB to IV melanoma. About 35 adults will receive the drugs, then have surgery to remove any remaining cancer. The main goal is to see…

This trial tests whether a culturally grounded supportive care navigation program can reduce emergency room visits, hospitalizations, and urgent care use among Hispanic/Latinx patients receiving cancer treatment. Participants are randomly assigned to either usual care or the inte…

This trial tests whether online peer education can help people with type 2 diabetes become more physically active. Participants will be placed in groups led by peers who have type 2 diabetes and exercise above recommended levels. The study measures changes in daily step count, al…

This study tests whether a quick bedside ultrasound can help doctors decide if new mothers with preeclampsia need a diuretic (water pill) to lower their blood pressure. About 96 postpartum patients will be enrolled. The goal is to see if this approach speeds up blood pressure rec…

This study compares two versions of a minimally invasive procedure called POEM for treating achalasia, a swallowing disorder. The standard POEM often causes severe heartburn afterward. The new version, Sling-Fiber Preserving POEM, aims to reduce that risk by leaving certain stoma…

This phase 2 trial will test whether a special PET scan using Flotufolastat F18 can accurately detect any remaining prostate cancer after focal therapy (like cryotherapy or HIFU). About 60 men with prostate cancer who haven't had prior treatment will get the scan before and after…

This study tests whether using an AI chatbot like ChatGPT during arguments can improve parent-child relationships. About 120 parent-child pairs will either use the chatbot or take a break before discussing tough topics. Researchers will measure changes in communication and relati…

This trial tests whether an 8-week virtual reality-based cognitive behavioral therapy (VR-CBT) program, done at home before elective spine surgery, can improve recovery and quality of life. Adults scheduled for spinal fusion will be randomly assigned to receive VR-CBT plus usual …

This study tests whether an intelligent chatbot can help people quit smoking by joining their private online support groups. 120 adult smokers who are ready to quit within 10 days will be split into two groups: one with a chatbot that responds when no human does, and one with a s…

This study looks at whether using adhesive strips (like Steri-Strips) instead of traditional stitches leads to better results for small, simple cuts on the face. About 62 adults with facial cuts smaller than 2.5 cm will be randomly assigned to get either strips or stitches. The g…

This study will test whether teaching patients to mindfully listen to jazz music for 15 minutes can lower their pain while they wait in the emergency department. The researchers will enroll 60 adults with neck or back pain and compare the music approach to a standard mindful pain…

This study will test if using an AI chatbot like ChatGPT can help people with generalized anxiety disorder or major depressive disorder who are already in regular therapy. Researchers plan to recruit 204 adults in the U.S. who are currently in individual therapy. Participants wil…