University Of California, Irvine

This study tests whether giving two immunotherapy drugs (fianlimab and cemiplimab) before surgery can shrink advanced melanoma tumors. About 35 adults with stage IIIB-IV melanoma that can be surgically removed will receive the drug combination, then have surgery. The goal is to s…

This study compares two versions of a minimally invasive surgery (POEM) for achalasia, a condition where the esophagus doesn't relax properly. The standard surgery often causes severe heartburn (GERD). The modified version tries to preserve certain muscle fibers to lower that ris…

This early-phase study tests whether a single dose of two immunotherapy drugs can increase cancer-fighting immune cells inside tumors. It includes 34 adults with untreated stomach or esophageal cancers that have not spread and carry a specific gene change called ARID1A. The goal …

This study tests whether using a chatbot to guide communication can improve relationship satisfaction between parents and their children. About 120 parent-child pairs (kids aged 12-17) will use the chatbot regularly and report on their communication. The goal is to see if technol…

This study tests whether a quick, non-invasive bedside ultrasound can help doctors decide if new mothers with preeclampsia need a diuretic (water pill) to lower their blood pressure. About 96 postpartum women with preeclampsia will receive ultrasound-guided treatment within 24 ho…

This study tests whether N-Acetyl-Cysteine (NAC), a supplement, can reduce memory and thinking problems caused by chemotherapy in ovarian cancer patients. About 102 women with advanced ovarian cancer will take NAC alongside their standard platinum-based chemo. The goal is to find…

This study tests whether an intelligent chatbot can help people quit smoking by joining small online support groups. 120 adult smokers who are ready to quit will be split into two groups: one with a chatbot that responds to messages, and one with a simple bot that only posts dail…

This study looks at two ways to close small cuts on the face: sticky strips (like Steri-Strips) and traditional stitches. The goal is to see which method causes less pain, makes patients happier, and leads to a better-looking scar. About 62 adults with small, simple facial cuts w…

This study looks at whether a short music mindfulness video can help lower pain in adults with neck or back pain while they wait in the emergency room. About 60 people will take part. Half will watch a video on using music for pain and then listen to jazz for 15 minutes. The othe…

This study explores whether artificial intelligence can support people already in therapy for anxiety or depression. Researchers will enroll 204 adults who are currently seeing a therapist. Participants will use an AI tool alongside their regular sessions to see if it improves sy…