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Mouthwash showdown: listerine vs. lumineux – which changes your microbiome?

NCT ID NCT05603650

Knowledge-focused Sponsor: University of California, Irvine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how two over-the-counter mouthwashes (Listerine and Lumineux Oral Essentials) affect bacteria and three common viruses in the mouth and gut. Two hundred healthy adults aged 18-25 will rinse twice daily with one of the mouthwashes or water for about six months. Researchers will collect mouth swabs and stool samples to track changes in the microbiome.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mouthrinse (Listerine or Lumineux Oral Essentials)
What this could lead to
If successful, this could reveal how common mouthwashes influence oral and gut health, potentially guiding better hygiene choices.
What could go wrong
This is an early-stage observational study with no direct treatment goal. Results may not lead to any health recommendations or clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2021

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Eligible men and non-pregnant and non-lactating women of all races age 18-25. * Volunteers must consent to participate in all scheduled exam visits and procedures. * Volunteers must be available for follow up on the telephone. * Healthy gums or gums that bleed when you brush them. Exclusion Criteria: * Volunteers unable or unwilling to sign the informed consent form. * Less than 20 teeth (excluding third molars). * Individuals who have taken antibiotics in the previous 3 months. * Presence of any condition, abnormality, or situation at Baseline that in the opinion of the Principal Investigator may preclude the volunteer's ability to comply with study requirements, including completion of the study or the quality of the data.

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Conditions

The condition(s) this trial relates to.

infectious disease viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Microbial colonization Oral bacterial infection Oral infection Viral infection

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beckman Laser Institute and Medical Clinic

    RECRUITING

    Irvine, California, 92612, United States

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