Assistance Publique Hopitaux De Marseille

This study looked at whether it is safe to reduce or narrow antibiotics once doctors know which germ is causing a severe infection (sepsis). 120 intensive care patients were randomly assigned to either continue their original broad antibiotics or switch to a more targeted treatme…

This study tested a combination of two chemotherapy drugs (BCNU and TMZ) given before radiation therapy in 53 people newly diagnosed with a rare type of brain cancer called anaplastic oligodendroglioma. The goal was to see how well the drugs shrank tumors and to learn more about …

This pilot study tested a non-invasive brain stimulation technique called tDCS in 17 people with drug-resistant epilepsy. The stimulation was personalized using prior brain recordings to target the exact area causing seizures. The goal was to see if this approach could safely red…

This study tested a new treatment for wrist arthritis that didn't get better with standard care. Doctors injected a mix of the patient's own fat and platelet-rich plasma into the wrist joint. The goal was to see if it is safe and can reduce pain and improve function, possibly del…

This study looked at 100 adults with lupus nephritis (kidney inflammation caused by lupus) who were in stable remission. Researchers wanted to see if it was safe to stop their maintenance immunosuppressive drugs after 2 years, while continuing hydroxychloroquine and possibly low-…

This study looked at whether a class of diabetes drugs called GLP-1 receptor agonists can improve heart function and reduce fat around the heart in obese people with type 2 diabetes. The researchers measured heart fat and function using MRI scans in 44 participants. The goal was …

This study tested whether continuously monitoring oxygen levels in the blood (ScvO2) during major abdominal surgery helps doctors give fluids more precisely, reducing complications. It included 220 adults over 50 undergoing planned, lengthy abdominal surgery. The goal was to see …

This study looked at whether a blood test called the basophil activation test (BAT) can accurately diagnose food allergies in children, potentially replacing the need for oral food challenges (OFCs). Researchers tested 116 children aged 0-18 who were already scheduled for an OFC.…

This study tested whether a special type of MRI that measures sodium levels in the brain can help doctors locate the exact area causing seizures in people with drug-resistant epilepsy. 78 adults with epilepsy who were being considered for surgery had a sodium MRI scan. The goal w…

This study tested a new, minimally invasive procedure for people with grade II or III hemorrhoids. Instead of surgery, doctors used tiny coils to block the main artery supplying blood to the hemorrhoids, aiming to shrink them and reduce pain. The study included 26 participants an…

This study compares two methods of giving a nerve block to control pain after lung surgery (thoracotomy). One method uses ultrasound to guide the needle, the other uses a camera inside the chest during minimally invasive surgery. The goal is to see which approach reduces the need…

This study tested whether a 50% nitrous oxide (laughing gas) and oxygen mixture can reduce pain during a legal abortion done with local anesthesia. 71 adults took part. The main goal was to measure pain during the procedure, with follow-up pain checks and side effects recorded. T…

This study tested whether regularly doing a set of gentle stretching poses (Stretching Postural®) could help pregnant women with new lower back pain. Sixty women with low-risk pregnancies were split into two groups: one received standard advice plus the stretching routine, the ot…

This study tested a personalized exercise program for children aged 5 to 17 with advanced cancer that cannot be cured. The program included walking on a treadmill and muscle-strengthening exercises, with the goal of seeing if it is safe and tolerable. Only 4 children took part, a…

This study tested whether special video games controlled by muscle signals (EMG) can improve walking in children with cerebral palsy. Thirty children aged 2 to 10 with mild to moderate CP played these games alongside physical therapy. The goal was to help them better control ankl…

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This study tested whether a special gas system called Airseal® can reduce pain after laparoscopic hysterectomy compared to the standard system. 80 women having the surgery for non-cancer reasons were randomly assigned to one of the two systems. The main goal was to measure pain l…

This study tested whether using virtual reality (VR) therapy before lung transplant surgery could help prevent anxiety, depression, and post-traumatic stress disorder (PTSD) after the ICU stay. 62 adults on the lung transplant waiting list took part. Patients in the VR group used…

This study looked at 160 adults with lupus and their spouses to understand how the disease impacts their relationship, emotions, and daily life. Researchers used surveys and interviews to capture the physical, psychological, and social effects. The goal is to use these insights t…

This completed study looked at 262 people with dilated cardiomyopathy, a condition where the heart is enlarged and weak. Researchers used a special MRI technique (T1 mapping) to measure scarring (fibrosis) in the heart muscle. The goal was to see if the amount of scarring could p…

This study looked at how the numbing drug lidocaine behaves in the body when given as a special type of local anesthesia for mastectomy. Researchers took blood samples from 6 women over 48 hours to measure lidocaine levels. The goal was to better understand the drug's safety and …

This study compared two blood-filtering techniques—plasma exchange and immunoadsorption—in 40 patients with severe kidney failure caused by ANCA vasculitis or anti-GBM disease. Both methods aim to rapidly remove harmful antibodies while waiting for immune-suppressing drugs to tak…

This study looked at 60 epilepsy patients who already had electrodes implanted in their brains for surgery planning. Researchers recorded brain activity simultaneously using scalp EEG, MEG, and the implanted electrodes. The goal was to see how well non-invasive methods can detect…

This completed study from a French hospital looked at long-term after-effects in 56 adults who had severe malaria. Researchers used a questionnaire to check for physical, thinking, and emotional problems one year after diagnosis. The goal is to better understand and track these l…

This study tested a special auditory training program (MPAA) in 22 deaf children aged 4 to 10 who have cochlear implants. The program uses different sounds like speech and music to improve skills such as identifying and remembering sounds. The goal was to see if the training help…

This study used MRI scans to look at blood flow in the lungs of 30 people with COPD, both at rest and after mild exercise. The goal was to learn more about how the disease affects lung blood vessels, which is not well understood. By improving this knowledge, doctors hope to bette…

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study involved 50 women and used a new, fast 3D MRI method to watch how pelvic organs move. The goal was to better understand pelvic floor disorders, which affect many women's quality of life. The approach combined high-resolution MRI with dynamic imaging to create 3D models…

This study looked at 11 people with a repaired heart condition called tetralogy of Fallot who needed a new pulmonary valve. Researchers used MRI scans to measure heart muscle stiffness (fibrosis) and how well the heart pumped during rest and exercise. The goal was to see if these…

This study looked at how patients and healthcare workers experienced a new way of organizing primary care, where different professionals work together as a team. Researchers interviewed 48 patients and staff from a health center in France. The goal was to understand people's expe…

This study looked at abnormal electrical activity in brain circuits of 23 people with Parkinson's disease. Researchers measured how brain signals travel between deep brain regions and the motor cortex. The goal was to understand why these rhythms become stuck in a harmful pattern…

This study looked at a rare disease called IgG4-related disease, which causes swelling and scarring in organs. Researchers compared immune cells in the blood of 75 people: those with the disease, those with Sjogren syndrome, and healthy volunteers. The goal was to better understa…

This study looked at antibodies in the intestines of 160 people: 80 with Crohn's disease, 40 with ulcerative colitis, and 40 without inflammatory bowel disease. Researchers took blood samples and intestinal biopsies to compare antibody levels in the gut versus the blood. The goal…

This study looks at how certain immune cells, called T cells and NK cells, may harm blood vessels in people with systemic sclerosis (scleroderma). Researchers will analyze blood samples from 30 participants, including patients and healthy volunteers, to measure a protein called F…

This completed study aimed to create a biobank of 'organoids'—tiny, 3D mini-tumors grown from liver cancer tissue. Researchers collected samples from 48 patients with colorectal cancer that spread to the liver or with primary liver cancer. The goal was to see if they could reliab…

This study tested a new type of brain sensor that is cheaper and easier to use than current ones. Researchers compared it to standard sensors in 4 people with epilepsy to see if it could detect abnormal brain activity. The goal is to make advanced brain imaging more widely availa…

This study looked at 124 people with septic shock to see if the difference in carbon dioxide levels between veins and arteries could predict their recovery. Researchers monitored patients closely for three days and tracked organ failure and survival at 28 days. The goal was to fi…

This study looked at whether measuring brain activity (rapid cortical oscillations) and observing general movements in very premature babies can help predict cerebral palsy. Researchers studied 44 infants born before 28 weeks of pregnancy. The goal was to see if these tests could…

This study measured how often muscle loss (sarcopenia) happens in men aged 70 and older with prostate cancer who are treated with radiation and hormone therapy. Researchers screened 112 patients using a simple questionnaire and body scans. The goal was to understand risk factors …

This study looked at whether certain cells in the blood (called endothelial progenitor cells) can help predict if someone will have another heart problem within a year after a heart attack. Researchers followed 180 people who had a heart attack and had a procedure to open blocked…

This study looked at whether natural (unprocessed) milk or pasteurized milk helps the gut mature faster in very premature babies born between 28 and 30 weeks. Fifty-five infants received small feedings of either natural or pasteurized milk. The goal was to see which type better s…

This study looked at how weak electric currents applied to the scalp can change brain activity in people with drug-resistant focal epilepsy. Researchers used special brain recordings to measure spikes and connections between brain regions during and right after stimulation. The g…

This study looked at 60 people with a genetic mutation that can cause a severe nerve disease called familial amyloid neuropathy. The goal was to see if two tests—MRI scans and a special electrical test called MUNIX—can detect early nerve damage before symptoms appear. No treatmen…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This study tested whether a computer model of the brain, called a 'virtual brain,' could help doctors interpret electrical signals from epilepsy patients. Twenty people with epilepsy who were already scheduled for brain surgery took part. The goal was to see if the model could im…

This study looked at tiny particles called microparticles in the blood of 41 people with colorectal cancer that had spread to the lining of the abdomen. The goal was to see if these particles could serve as a better way to detect this spread early, compared to current tests. Rese…

This study looked at blood samples from 24 people with axial spondyloarthritis (a type of inflammatory arthritis) and 12 healthy volunteers to understand how a receptor called KIR3DL2 contributes to inflammation. Researchers also tested whether a drug called IPH4102 could reduce …

This study looked at why antibiotics often fail to treat pneumonia in COVID-19 patients on ventilators. Researchers measured how much of the antibiotic piperacillin reaches the lungs in 34 adults with severe COVID-19 pneumonia. The goal was to understand if poor lung penetration …

This study looked for new ways to detect and track ALS using powerful MRI scanners. Researchers scanned the brain, spinal cord, and muscles of 22 people with ALS and healthy volunteers over six months. The goal was to find imaging markers that could lead to earlier diagnosis and …

This study used a very powerful 7 Tesla MRI to look for tiny brain changes in 15 people with idiopathic REM sleep behavior disorder (iRBD) compared to 15 healthy volunteers. iRBD is a sleep condition that often leads to Parkinson's disease years later. The goal was to find early …

This study looked at how Hirschsprung disease, a rare birth defect affecting the bowel, impacts brain development and quality of life in children aged 8 to 13. Researchers tested thinking skills and surveyed families to understand long-term effects after surgery. The goal was to …

This study looked at how certain genes are turned on or off in people with major depression compared to healthy individuals. Researchers analyzed blood samples from 30 participants to track changes in gene activity over time. The goal was to better understand the biological proce…

This study looked at whether a blood test that measures gene activity (transcriptomic score) can help doctors better track lupus disease activity. Researchers studied 80 adults with lupus, comparing the new gene-based score with standard clinical scores. The goal was to find a mo…