Assistance Publique Hopitaux De Marseille

This study tests whether non-invasive ventilation (a breathing mask that pushes air into the lungs) works better than standard oxygen masks for people who nearly drowned and have trouble breathing. Researchers will compare how many patients in each group need a breathing tube (in…

This study tests whether injecting a patient's own fat-derived cells during standard surgery can safely improve outcomes for urethral narrowing (stenosis). About 20 men aged 18-85 with bulbar stenosis ≤3 cm and at least one prior procedure will receive either standard surgery alo…

This study tests the safety of injecting a patient's own fat-derived cells (stromal vascular fraction) combined with tiny skin grafts to treat anal fistulas that haven't healed with standard care in Crohn's disease. It includes 25 adults who didn't respond to a previous similar t…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce seizures in people with drug-resistant epilepsy. About 60 participants will receive either real or sham (fake) stimulation over 10 days. The goal is to see if this approach safely lowers se…

This study aims to find hidden genetic causes in people with rare diseases like intellectual disability or weak muscle tone who have not been diagnosed by standard DNA tests. Researchers will analyze RNA from blood and skin samples to spot harmful variants. The goal is to end the…

This study tests whether linezolid works better than vancomycin at preventing surgical site infections in people having elective surgery who are allergic to common antibiotics or at risk for MRSA. About 1,160 adults will be randomly assigned to receive one of the two antibiotics …

This study looks at whether a short hypnosis session, led by a specially trained nurse, can reduce anxiety in children aged 5 to 12 before they get anesthesia for surgery. About 60 kids will take part, and their anxiety levels will be measured during anesthesia induction. The goa…

This study compares two methods of pain control during a water vapor therapy (Rezum) for enlarged prostate. One group gets general anesthesia, the other gets local anesthesia injected directly into the prostate using a special catheter. The goal is to see if local anesthesia can …

This study looks at two ways to help people who had a stroke more than 6 months ago get more physical activity. One group will follow a personalized exercise program at a special facility, while the other group will do their own program at home. The goal is to see which approach …

This study investigates whether certain antibodies (anti-HIF1a) are linked to liver damage in people with anorexia nervosa. Researchers will test 250 participants, including those with and without anorexia, to confirm earlier findings. The goal is to better understand the cause o…

After losing their voice box to cancer, some people learn to speak using their throat and esophagus (oroesophageal voice). This study looks at whether personality traits, measured by a questionnaire, are linked to success in learning this new voice. Researchers will study 40 adul…

This study looks at whether archaea, a type of microbe, are involved in tooth decay. Researchers will collect saliva and cavity tissue samples from 200 adults to check for the presence and amount of archaea. The goal is to better understand what causes cavities and possibly find …

This study tracks fertility markers in 80 melanoma patients (women aged 18-37, men aged 18-45) before, during, and after adjuvant therapy with anti-PD-1 or targeted treatments. Researchers measure hormone levels in women and sperm quality in men to see how these change over time.…

This study aims to find epigenetic markers in the blood that could predict whether a patient with sepsis will develop the more dangerous septic shock. Researchers will take blood samples from 25 male patients after major digestive cancer surgery who develop sepsis. By comparing m…

This study looks at 100 adults with newly diagnosed glioblastoma, the most common and aggressive brain tumor. Researchers will measure certain proteins (MMP2 and MMP9) in blood and tumor tissue, and compare them with MRI scans. The goal is to better understand how these proteins …

This study looks at whether closely tracking a patient's breathing effort can help doctors decide the best time to remove a life-support machine called ECMO in people with severe lung failure (ARDS). About 50 adults on ECMO will be randomly assigned to have their breathing monito…

This study looks at 170 adults with severe breathing failure (ARDS) in the ICU. Researchers will take a blood sample to measure a clotting marker and then check if those who develop a pulmonary embolism (a blood clot in the lung) have higher levels. The goal is to see if this blo…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…

This study tests whether a new ultrasound technique, called speckle tracking, can better predict when patients in the intensive care unit will struggle after having their breathing tube removed. Researchers will perform heart and lung ultrasounds on 110 adults during a weaning tr…

This study aims to develop and validate a new 3D camera technique to objectively measure facial symmetry after reconstructive surgery. Researchers will enroll 50 adults who have had facial reconstruction due to tumor removal, trauma, or other causes. The goal is to identify facto…

This study looks at how being born moderately early (32-36 weeks) affects the way babies' brains process speech sounds and learn words. Researchers will measure brain activity using EEG while babies listen to syllables, and track their vocabulary growth over time. The goal is to …

This study is creating a registry of 200 infants diagnosed with a rare, severe epilepsy that starts in the first month of life, caused by changes in the KCNQ2 gene. Researchers will track the children's development, brain activity, and seizures over time to better understand the …

This study looks at whether using video calls for geriatric checkups before cancer treatment can lower the number of unplanned hospital stays for patients aged 75 and older who live far from specialists. About 500 participants will be randomly assigned to either standard care or …

This study tests whether a non-invasive light sensor placed on the lower back can detect low oxygen levels in the kidneys during lung transplant surgery. The goal is to see if these readings can predict which patients will develop acute kidney failure shortly after the operation.…