Assistance Publique Hopitaux De Marseille

This study tests the safety of injecting a patient's own fat-derived cells into hard-to-heal anal fistulas caused by Crohn's disease. It includes up to 25 adults who did not improve in an earlier trial. The goal is to see if the treatment is safe and can help close the fistulas.

This study tests a new treatment for urethral stenosis, a condition where the tube that carries urine out of the body becomes narrowed. In addition to standard surgery, doctors will inject a mixture of cells from the patient's own fat tissue. The goal is to see if this is safe an…

This study compares two ways to help people who have low oxygen after drowning: a breathing machine (CPAP) that pushes air into the lungs, versus a standard face mask with extra oxygen. The goal is to see if the machine can improve oxygen levels enough to avoid needing a breathin…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce seizures in people with drug-resistant epilepsy. About 60 participants will receive either real or sham (fake) stimulation over 10 days. The goal is to see if this approach safely lowers se…

This study tests whether linezolid works better than vancomycin at preventing surgical site infections in people having elective surgery who are allergic to common antibiotics or at risk for MRSA. About 1,160 adults will be randomly assigned to receive one of the two antibiotics …

This study looks at whether a short hypnosis session, led by a specially trained nurse, can reduce anxiety in children aged 5 to 12 before they get anesthesia for surgery. About 60 kids will take part, and their anxiety levels will be measured during anesthesia induction. The goa…

This study compares two methods of pain control during a water vapor therapy (Rezum) for enlarged prostate. One group gets general anesthesia, the other gets local anesthesia injected directly into the prostate using a special catheter. The goal is to see if local anesthesia can …

This study looks at two ways to help people who had a stroke more than 6 months ago get more physical activity. One group will follow a personalized exercise program at a special facility, while the other group will do their own program at home. The goal is to see which approach …

This study tracks how melanoma treatments like immunotherapy and targeted therapy affect fertility in women (ages 18-37) and men (ages 18-45). Researchers measure hormone levels and sperm quality before, right after, and one year after treatment. The goal is to understand these e…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…

This study investigates whether certain antibodies (anti-HIF1a) are linked to liver damage in people with anorexia nervosa. Researchers will test 250 participants, including those with and without anorexia, to confirm earlier findings. The goal is to better understand the cause o…

This study tests whether a new ultrasound technique, called speckle tracking, can better predict when patients in the intensive care unit will struggle after having their breathing tube removed. Researchers will perform heart and lung ultrasounds on 110 adults during a weaning tr…

This study involves 170 adults in intensive care with Acute Respiratory Distress Syndrome (ARDS), a severe lung condition. Researchers will take a blood sample to measure a clotting marker called EV-TF. They will then check if patients who develop a pulmonary embolism (a blood cl…

This study aims to develop and validate a new 3D camera technique to objectively measure facial symmetry after reconstructive surgery. Researchers will enroll 50 adults who have had facial reconstruction due to tumor removal, trauma, or other causes. The goal is to identify facto…

This study looks at how being born moderately early (32-36 weeks) affects the way babies' brains process speech sounds and learn words. Researchers will measure brain activity using EEG while babies listen to syllables, and track their vocabulary growth over time. The goal is to …

This study is creating a registry of 200 infants diagnosed with a rare, severe epilepsy that starts in the first month of life, caused by changes in the KCNQ2 gene. Researchers will track the children's development, brain activity, and seizures over time to better understand the …

This study looks at whether measuring a patient's breathing effort can help doctors decide the best time to remove ECMO support in adults with severe lung failure (ARDS). About 50 participants will be randomly assigned to have their breathing monitored or not, with the goal of re…

This study aims to help people with rare genetic diseases who have not received a clear diagnosis despite standard DNA testing. Researchers will analyze RNA from blood and skin samples of 62 patients with intellectual disability or weak muscle tone to find hidden genetic causes. …

This study looks at 100 adults with a new diagnosis of glioblastoma, the most common and aggressive brain tumor. Researchers will measure certain proteins (MMP2 and MMP9) in blood and tumor tissue, and compare them with MRI brain scans. The goal is to learn how these proteins cha…

This study looks at whether using video calls for geriatric checkups before cancer treatment can lower the number of unplanned hospital stays for patients aged 75 and older who live far from specialists. About 500 participants will be randomly assigned to either standard care or …

This study looks at whether archaea, a type of microbe, are involved in causing cavities. Researchers will collect saliva from 200 adults with dental decay to check for these organisms. The goal is to better understand cavity microbiology and potentially improve prevention or tre…

This study tests whether a non-invasive light sensor placed on the lower back can detect low oxygen levels in the kidneys during lung transplant surgery. The goal is to see if these readings can predict which patients will develop acute kidney failure shortly after the operation.…

This study looks at whether certain personality traits help people learn to speak using a special voice (oroesophageal voice) after having their voice box removed (laryngectomy). Researchers will give personality tests and voice recordings to 40 adults who have had this surgery. …

This study aims to find new markers that can predict whether sepsis will progress to the more dangerous septic shock. Researchers will compare epigenetic markers in 25 male patients (ages 45-75) who develop sepsis after major digestive cancer surgery. The goal is to identify earl…