Assistance Publique Hopitaux De Marseille

This study tested a combination of two chemotherapy drugs, BCNU and TMZ, given before radiation therapy in 53 people newly diagnosed with a rare type of brain tumor (anaplastic oligodendroglioma or oligoastrocytoma). The goal was to see how many patients' tumors shrank with this …

This study tested a non-invasive brain stimulation technique called tDCS in 17 people with epilepsy that does not respond to medication. The stimulation was personalized based on each person's brain mapping from a prior procedure (SEEG). The goal was to see if it could reduce sei…

This study looked at whether doctors can safely reduce or narrow the antibiotics given to patients with severe sepsis once the exact germ causing the infection is identified. The goal was to see if this approach, called de-escalation, is as good as continuing the original broad a…

This study looked at whether a class of diabetes drugs called GLP-1 receptor agonists can improve heart function and reduce fat around the heart in obese people with type 2 diabetes. The researchers measured heart fat and function using MRI scans in 44 participants. The goal was …

This study tested a new treatment for wrist arthritis that uses a mixture of a patient's own fat and platelet-rich plasma (from their blood) injected directly into the wrist joint. The goal was to see if this approach is safe and can reduce pain and improve function, potentially …

This study looked at 100 adults with lupus nephritis (a kidney inflammation caused by lupus) who had been in stable remission for at least 2 years. Researchers wanted to see if it was safe to stop their maintenance immunosuppressive drugs, while continuing hydroxychloroquine and …

This study tested whether continuously monitoring oxygen levels in the blood (ScvO2) during major abdominal surgery helps doctors give fluids more precisely, reducing complications. It included 220 adults over 50 undergoing planned, lengthy abdominal surgery. The goal was to see …

This study tested a new, non-invasive MRI technique that measures sodium levels in the brain to locate the exact area causing seizures in people with drug-resistant epilepsy. 78 patients who were already scheduled for epilepsy surgery received a sodium MRI scan before their opera…

This study looked at 44 very preterm babies (born before 28 weeks) to see if special brain wave patterns and movement checks could help predict cerebral palsy. Researchers stimulated the babies' hands or feet and recorded brain activity. The goal was to find early signs that migh…

This study looked at whether a blood test called the basophil activation test (BAT) can accurately diagnose food allergies in children, potentially replacing the need for oral food challenges (OFCs). Researchers tested 116 children and compared BAT results with standard OFC outco…

This study tested whether special video games controlled by muscle signals (EMG) can improve walking in children with cerebral palsy. Thirty children aged 2 to 10 with mild to moderate CP played these games alongside physical therapy. The goal was to help them better control ankl…

This study tested whether doing special stretching exercises (Stretching Postural®) can help reduce lower back pain in pregnant women. 60 women with new back pain during pregnancy were split into two groups: one did the stretches plus usual care, the other had usual care alone. T…

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This study tested a new way to treat hemorrhoids by blocking the main blood supply to the area using tiny coils inserted through a blood vessel in the leg. The goal was to see if this procedure could safely reduce pain and other symptoms. 26 people with grade II or III hemorrhoid…

This study tested two methods of numbing chest nerves (thoracic paravertebral block) to control pain after lung surgery. 180 adults having minimally invasive lung surgery took part. The goal was to see if the surgeon placing the numbing medicine during surgery works as well as th…

This study tested whether a mixture of 50% nitrous oxide (laughing gas) and 50% oxygen can reduce pain during a legal abortion done under local anesthesia. 71 adults took part. Researchers measured pain during the procedure, right after, and two hours later, and also tracked any …

This study tested whether a special gas system called Airseal® can reduce pain after laparoscopic hysterectomy compared to the standard system. 80 women having the surgery for non-cancer reasons were randomly assigned to one of the two systems. The main goal was to measure pain l…

This study tested whether using virtual reality (VR) therapy before lung transplant surgery could help prevent anxiety, depression, and post-traumatic stress disorder (PTSD) after the ICU stay. 62 adults on the lung transplant waiting list took part. Patients in the VR group used…

This study tested a personalized exercise program (walking and strength exercises) in 4 children aged 5-17 with advanced cancer that could not be cured. The goal was to see if the program was safe and tolerable. The approach was to slowly increase exercise intensity based on each…

This study involved 60 epilepsy patients who already needed brain electrodes as part of their care. Researchers recorded brain activity simultaneously from the scalp and from inside the brain to see how well non-invasive methods can detect seizure-related signals. The goal was to…

This study looked at 60 people with a genetic mutation that can cause a severe nerve disease called familial amyloid neuropathy. The goal was to see if two tests—MRI scans and a special electrical test called MUNIX—can detect early nerve damage before symptoms appear. No treatmen…

This study used MRI scans to look at blood vessels in the lungs of 30 people with COPD, a chronic lung disease. The goal was to learn how these vessels change from rest to exercise, which could help doctors better understand disease flare-ups and the development of high blood pre…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This study looked at abnormal brain wave patterns in 23 people with Parkinson's disease who already had deep brain stimulation electrodes implanted. The goal was to understand how these brain rhythms spread between different brain areas. The findings may help develop better treat…

This study tested a new type of brain scanner (MEG) that uses cheaper sensors called optical pumping magnetometers. The goal was to see if these sensors can detect abnormal brain activity in people with epilepsy as well as the expensive standard sensors. Only 4 people participate…

This study looked at how patients and healthcare professionals experienced a new way of organizing primary care, where different types of providers work together as a team. Researchers interviewed 48 patients and staff from a health center in France to understand their views and …

This study looked at how weak electric currents applied to the scalp change brain activity in people with drug-resistant focal epilepsy. Researchers used special brain recordings to measure these changes during and right after stimulation. The goal was to understand how the curre…

This study collected leftover liver tissue from 48 adults with colorectal cancer that spread to the liver or with liver cancer. The goal was to grow tiny 3D mini-livers (organoids) in the lab to create a biobank for future drug testing. This research does not offer a treatment bu…

This study tested whether a computer model of the brain, called a 'virtual brain,' could help doctors interpret electrical signals from epilepsy patients. Twenty people with epilepsy who were already scheduled for brain surgery took part. The goal was to see if the model could im…

This study looked at tiny particles called microparticles in the blood of 41 people with colorectal cancer that had spread to the lining of the abdomen. The goal was to see if these particles could serve as a better way to detect this spread early, compared to current tests. Rese…

This study looked at blood samples from 24 people with axial spondyloarthritis (a type of inflammatory arthritis) and 12 healthy volunteers to understand how a receptor called KIR3DL2 contributes to inflammation. Researchers also tested whether a drug called IPH4102 could reduce …

This study looked at why antibiotics often fail to treat pneumonia in COVID-19 patients on ventilators. Researchers measured how much of the antibiotic piperacillin reaches the lungs in 34 adults with severe COVID-19 pneumonia. The goal was to understand if poor lung penetration …

This study looked at 40 adults with severe kidney disease caused by ANCA vasculitis or Goodpasture syndrome. Researchers compared two blood-filtering techniques—plasma exchange and immunoadsorption—to see which removes harmful antibodies faster. The goal was to gather information…

This study tested a new 3D MRI method to watch how pelvic organs move in real time. Researchers aimed to better understand pelvic floor disorders, which affect many women's quality of life. 50 adult women participated, and the goal was to create tools for diagnosis and simulation…

This study looked for new ways to detect and track ALS using powerful MRI scanners. Researchers scanned the brain, spinal cord, and muscles of 22 people with ALS and healthy volunteers over six months. The goal was to find imaging markers that could lead to earlier diagnosis and …

This study looked at 124 people with septic shock to see if the difference in carbon dioxide levels between veins and arteries can help predict who will get worse. Researchers monitored patients closely for three days and tracked organ failure and survival at 28 days. The goal wa…

This study used a very powerful 7 Tesla MRI to look for tiny brain changes in 15 people with idiopathic REM sleep behavior disorder (iRBD) compared to 15 healthy volunteers. iRBD is a sleep condition that often leads to Parkinson's disease years later. The goal was to find early …

This study looked at whether a structured auditory training program can improve listening and language skills in deaf children aged 4 to 10 who already have a cochlear implant. The program focused on four key skills: identifying sounds, telling sounds apart, analyzing sound scene…

This study looked at how Hirschsprung disease, a rare birth defect affecting the bowel, impacts brain development and quality of life in children aged 8 to 13. Researchers tested thinking skills and surveyed families to understand long-term effects after surgery. The goal was to …

This study looked at 11 people with repaired tetralogy of Fallot who needed a new pulmonary valve. Researchers used heart MRI scans to measure scarring and pumping function before and after surgery. The goal was to find out if these scans can predict how well the heart will recov…

This study looked at whether natural (unprocessed) milk or pasteurized milk helps the gut mature faster in very premature babies born between 28 and 30 weeks. Fifty-five infants were given small amounts of either natural or pasteurized milk to see how their digestive systems resp…

This study looked at a rare disease called IgG4-related disease, which can damage organs. Researchers measured special immune cells (follicular helper T cells) in the blood of 75 people: patients with the disease, patients with Sjogren syndrome, and healthy volunteers. The goal w…

This study looked at 56 adults who had severe malaria to see what long-term health problems they faced one year later. The main goal was to find out how often issues like kidney failure and brain disorders occur in adults, since most research has focused on children. The results …

This study looked at whether certain blood markers (endothelial progenitor cells) can help predict the risk of a major heart event within one year after a heart attack or unstable angina. Researchers measured these markers in 180 patients who had a procedure to open blocked heart…

This study looked at 262 people with dilated cardiomyopathy, a condition where the heart is enlarged and weak. Researchers used special MRI scans to measure scarring (fibrosis) in the heart muscle. They wanted to see if the amount of scarring could help predict serious events lik…

This study looked at how certain genes are turned on or off in people with major depression compared to healthy individuals. Researchers analyzed blood samples from 30 participants to track changes in gene activity over time. The goal was to better understand the biological proce…

This study looked at whether a blood test that measures gene activity (transcriptomic score) can help doctors better track lupus disease activity. Researchers studied 80 adults with lupus, comparing the new gene-based score with standard clinical scores. The goal was to find a mo…

This study looked at how certain immune cells (T cells and NK cells) might damage blood vessels in people with systemic sclerosis (scleroderma). Researchers took blood samples from 30 participants to measure a molecule called Fractalkine and study how these cells interact with bl…

This study checked if measuring certain cells in the blood can predict serious heart events like heart attacks or the need for another procedure after a stent placement. Researchers followed 170 adults for up to a year after their stent procedure. The goal was to see if these blo…

This study looked at whether measuring certain antibodies (ASCA) from gut tissue samples can help understand Crohn's disease better than standard blood tests. Researchers compared results from 80 people with Crohn's, 40 with ulcerative colitis, and 40 without inflammatory bowel d…

This study looked at how lupus impacts the emotional and social lives of 160 patients and their spouses. Researchers measured quality of life and gathered insights to help doctors offer better support. The goal is to improve care for both patients and their partners.

This study looked at how the numbing drug lidocaine behaves in the body when given as a large injection under the skin for mastectomy. Six women having breast removal surgery took part. Researchers took blood samples over 48 hours to measure lidocaine levels and check how well it…

This study looked at how common muscle loss (sarcopenia) is in men aged 70 and older with prostate cancer who receive radiation and hormone therapy. The goal was to understand risk factors and how hormone therapy affects muscle mass. 112 men took part, and the study used a simple…