Super MRI reveals hidden brain clues for Parkinson's risk
NCT ID NCT05976971
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study used a very powerful 7 Tesla MRI to look for tiny brain changes in 15 people with idiopathic REM sleep behavior disorder (iRBD) compared to 15 healthy volunteers. iRBD is a sleep condition that often leads to Parkinson's disease years later. The goal was to find early brain markers that could help diagnose and eventually treat Parkinson's earlier.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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31 people
The number who actually took part.
- Started
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Oct 2023
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria for patients with REM Sleep Behaviour Disorder : * Patient aged between 40 and 80 years old * Patient fulfilling the diagnostic criteria for RBD (International Classification of Sleep Disorders version 3, American Academy of Sleep Medicine, 2014) with polysomnographic confirmation (which will be carried out as part of the routine work-up); * UPDRS Part III score under or equal to 5 * The patient is enrolled in the French social security system * The patient understood and signed the consent to participate in the study. Inclusion Criteria for control group : * Patient aged between 40 and 80 years old * Score under or equal 4 for the RBD screening questionnaire * UPDRS Part III score under or equal 5 * The patient is enrolled in the French social security system * The patient understood and signed the consent to participate in the study. Exclusion Criteria : * Patient / Subject with a history of central nervous system disease (e.g. PD, Alzheimer's disease, stroke, brain tumour, multiple sclerosis, amyotrophic lateral sclerosis, etc.). If a doubt exist, this criterion will be left to the judgement of the principal investigator, who is a neurologist. * Contraindications to 7T MRI: presence of a metal in the body or in the eye, patient with a pacemaker or neurostimulator, cochlear implants or any implanted electronic medical equipment in general, metallic heart valve, aneurysm clips. * Claustrophobia. * Montreal Cognitive Assessment Test (MOCA) \< 25/30 * Pregnant or breast-feeding woman or protected person (under guardianship, curatorship, deprived of liberty).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Assistance - Publique Hôpitaux de Marseille
Marseille, 13005, France
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Other studies related to the condition(s) this trial covers.