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Can less be more? study tests cutting back antibiotics in sepsis

NCT ID NCT01626612

Disease control Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether it is safe to reduce or narrow antibiotics once doctors know which germ is causing a severe infection (sepsis). 120 intensive care patients were randomly assigned to either continue their original broad antibiotics or switch to a more targeted treatment. The goal was to see if the de-escalation approach could keep patients safe while reducing the risk of drug-resistant infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

120 people

The number who actually took part.

Start date

Feb 2012

Finished

Jul 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Major Subject; * Subject having a sepsis engraves(burns) defined according to the following criteria during the initiation of the probability antibiotic treatment: * Criteria of SIRS \[ 14 \], * And a suspected infection, * And a failure of organ: low blood pressure, respiratory failure, coma, hepatic insufficiency, renal insufficiency, thrombopénia, spontaneous extension of the TCA, * Subject for which an antibiotic treatment was begun within 6 hours following the diagnosis of sepsis engraves(burns); * Subject for which a taking with microbiological aim was made within 48 hours following the diagnosis of sepsis Exclusion Criteria: * Minor Subject, pregnant or breast-feeding woman; * Neutropénia (PN \< 1000 / mm3); * Absence of identification of a microorganism in the microbiological examinations; * Absence of Social Security; * Subject deprived of freedom or under guardianship; * Subject for which the lit(enlightened) consent is not collected(taken in) (itself and/or reliable person).

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Conditions

The condition(s) this trial relates to.

Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Severe sepsis

Contacts and locations

Locations

  • Assistance Publique Hopitaux de Marseille

    Marseille, 13354, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.