RHEUMATOID ARTHRITIS

This study tested whether giving higher doses of the drug infliximab, along with methotrexate, could better control rheumatoid arthritis in patients who weren't responding well to standard treatment. Researchers compared three different dose levels over 54 weeks in 327 patients. …

This study is testing whether a non-invasive, focused ultrasound treatment can reduce inflammation in people with certain types of inflammatory arthritis. Participants, including healthy volunteers and people with psoriatic arthritis, rheumatoid arthritis, or ankylosing spondylit…

This study tested whether adding the medication cilostazol to standard rheumatoid arthritis (RA) treatments could help patients feel better. For 6 months, 70 adults with moderate-to-severe RA either took their usual medications plus cilostazol or just their usual medications alon…

This study tested whether adding rebamipide, a medication typically used for stomach ulcers, to standard methotrexate treatment could better control rheumatoid arthritis. It involved 60 adults with active arthritis who were already taking standard disease-modifying drugs. Researc…

This study followed 162 patients for up to 10 years after receiving a G7 Acetabular hip replacement system. The goal was to see how well the implant performed, how safe it was, and how much it improved patients' pain and mobility over time. Researchers tracked patients' hip funct…

This study compared how well different drug combinations work for controlling rheumatoid arthritis in real-world patients. Researchers followed over 9,000 people to see whether taking certain arthritis drugs alone or with another medication called methotrexate provided better sym…

This study looked at switching patients with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis from receiving their infliximab medication through an intravenous (IV) infusion at a clinic to giving themselves a subcutaneous (SC) injection at home. The main goal was t…

This study followed 322 adults with moderate to severe rheumatoid arthritis for one year after they started treatment with the drug tocilizumab (Actemra/RoActemra) in their regular doctor's care. The goal was to see how well the drug worked to control disease activity and reduce …

This small, early-stage study tested whether a dietary supplement called short-chain fatty acids (SCFAs) could help control rheumatoid arthritis. It involved about 20 people whose arthritis wasn't well-controlled by their main medication. Researchers gave participants the supplem…

This study looked at what to do when the first biologic treatment for rheumatoid arthritis stops working effectively. Researchers compared two approaches: switching to a different drug in the same class versus trying a completely different type of biologic medication. The trial i…

This study tested whether following the DASH diet, a plan known for lowering blood pressure, could help people with rheumatoid arthritis. For 12 weeks, 49 participants either followed the DASH diet or ate as usual. Researchers measured changes in joint pain, inflammation, and dai…

This study developed and tested a new patient-centered program to help people with rheumatoid arthritis better manage their cholesterol and lower their risk of heart attack and stroke. It involved 101 participants and focused on education and support to improve screening and medi…

This study tested if two different versions of the same drug, called ianalumab (VAY736), are equally safe and behave the same way in the body. It involved 48 people with active rheumatoid arthritis who were already on standard treatment. The main goal was to check for side effect…

This study collected information on the safety and effectiveness of a biosimilar version of an existing rheumatoid arthritis drug when used in regular medical practice. It involved 77 patients with rheumatoid arthritis who were starting treatment with this specific medication. Th…

This study tested whether professional dental cleaning (nonsurgical periodontal therapy) could help people who have both rheumatoid arthritis and serious gum disease. Researchers wanted to see if reducing gum inflammation would also lower body-wide inflammation, potentially impro…

This study tested whether a specialized clinic visit could help people with rheumatoid arthritis. It checked if a nurse reviewing other health risks (like heart disease or infections) and teaching patients to track their own arthritis activity led to better care. About 970 stable…

This study tested a new daily pill called Proximod for people with active rheumatoid arthritis who weren't getting enough relief from standard medications. About 179 participants took either Proximod or a placebo pill for three months to see if it reduced joint swelling and pain.…

This study tested whether close, regular check-ups by a specialized nurse could spot the early return of rheumatoid arthritis symptoms in patients whose disease was well-controlled with the drug rituximab. The goal was to see if this nurse-led monitoring could detect a flare-up s…

This study looked at whether patients could safely switch from the brand-name drug Remicade to a very similar, lower-cost version called Inflectra. It involved 262 patients at a Paris hospital who were already using Remicade for conditions like rheumatoid arthritis or Crohn's dis…

This study followed 40 patients with moderate to severe rheumatoid arthritis for up to two years to see if the oral medication ABX464 remains safe and effective over time. All participants received the same daily dose of the drug, regardless of whether they received the real medi…

This was the first study in humans to test a new drug called SOL-116 for rheumatoid arthritis. Researchers gave single doses to 56 healthy volunteers and arthritis patients to check if it was safe and how the body processes it. The main goal was to understand side effects and det…

This was an early-stage study to test the safety of a new drug called EF-M2 (Immutalon) for people with moderate-to-severe rheumatoid arthritis. The drug is designed to calm the immune system by changing the behavior of specific inflammatory cells. Forty-eight participants receiv…

This study tested whether adding an experimental drug called MP-435 to a standard medication (methotrexate) could better control rheumatoid arthritis symptoms. It involved 112 adults whose arthritis was not fully controlled by methotrexate alone. For 12 weeks, participants receiv…

This study tested a program to help doctors and patients work together more closely when making treatment decisions for rheumatoid arthritis. It involved 900 Veterans with moderate to severe arthritis across multiple clinics. Researchers wanted to see if this teamwork approach le…

This study tested two different approaches to help rheumatoid arthritis patients safely stop taking steroid medications. Researchers compared gradually reducing steroids versus switching to a different steroid type in 102 patients whose arthritis was already well-controlled. The …

This study compared robot-assisted knee replacement surgery to standard surgery in 252 adults with severe knee pain from conditions like arthritis. The main goal was to see if the robotic system placed the new knee implant more accurately. Researchers also tracked surgery time, p…

This study tested if a supplement called 2-HOBA is safe and can help control rheumatoid arthritis. 32 adults with active arthritis took either 2-HOBA or a placebo pill three times a day for four weeks. Researchers checked for side effects and measured markers of inflammation and …

This study compared two types of knee replacement implants for people with severe arthritis. It tested whether a newer implant design (Vanguard) performed better than an older one (AGC) in terms of knee function and pain relief. The study involved 150 adults who needed a total kn…

This study tested whether reducing salt in the diet could help people with rheumatoid arthritis. Eighteen participants with moderate arthritis tried both high-salt and low-salt diets for eight weeks each, with a break in between. Researchers measured changes in joint inflammation…

This study tested a new smartphone app and support system designed to help people with rheumatoid arthritis track their symptoms between doctor visits. The goal was to see if this digital tool could improve patient satisfaction and help control disease activity. A trained manager…

This study compared two methods for knee replacement surgery in patients with severe arthritis. It aimed to see if using a computer navigation system during surgery leads to better long-term results than the standard technique. Researchers followed 192 patients to measure implant…

This early-stage study tested the safety of a single infusion of a patient's own stem cells, collected from their body fat, for treating active rheumatoid arthritis. It involved 15 adults to see if the treatment was safe and to check for early signs it might reduce joint inflamma…

This small study tested whether treating gum disease (periodontitis) could help reduce the severity of rheumatoid arthritis (RA) in people who have both conditions. Researchers enrolled 22 patients with both RA and gum disease to see if professional dental cleaning and treatment …

This large study investigated whether taking daily vitamin D or fish oil supplements could help prevent new autoimmune diseases, reduce body-wide inflammation, or lessen chronic knee pain. It involved over 25,000 U.S. adults without a prior history of cancer or heart disease. Res…

This study looked at whether switching patients to a higher concentration version of the drug adalimumab (brand name SIMLANDI™) causes less injection site pain than the standard version. It involved 324 Canadian adults with conditions like Crohn's disease, rheumatoid arthritis, o…

This study tested whether a specific set of hand exercises and education could improve hand function in women with rheumatoid arthritis. Six participants followed a 12-week home exercise program with four in-person coaching sessions. Researchers measured changes in hand function,…

This study tested if an injection of a drug called etanercept directly into a painful, swollen joint could work better than a standard steroid injection for people with rheumatoid arthritis. It involved 34 adults who had a painful flare-up in a joint like the knee or wrist. The g…

This study tested a digital self-management program called OPERAS for people with rheumatoid arthritis. The program included a web app to track symptoms and a physiotherapist who provided remote activity coaching using a Fitbit. Researchers wanted to see if this approach helped p…

This study tested whether a special probiotic and prebiotic blend, taken as a medical food, could help manage symptoms in people newly diagnosed with rheumatoid arthritis. All 143 participants were also taking the standard medication methotrexate. Researchers compared the blend t…

This study tested whether a 6-week walking program delivered over the phone could help people with arthritis manage their symptoms. Researchers enrolled 267 adults with various forms of arthritis and randomly assigned them to start the program immediately or after a year. The pro…

This study tested whether a special therapeutic taping method could help people with rheumatoid arthritis in their knee. Researchers compared the real taping technique against a fake, placebo tape to see which was better at reducing pain, improving walking ability, and lessening …

This early-stage study tested whether an experimental oral drug for rheumatoid arthritis makes skin more sensitive to sunlight. Researchers gave the drug to healthy adults and then exposed small patches of their skin to ultraviolet light to measure sunburn reactions. The goal was…

This study aimed to understand the connections between core muscle endurance, finger grip strength, fatigue, and hand function in people with rheumatoid arthritis (RA). Researchers compared 75 RA patients to 38 healthy people, measuring grip strength, core endurance, and using qu…

This study aimed to better understand how patients with rheumatoid arthritis process their key medication, methotrexate. Researchers tracked the drug and its byproduct in the urine of 62 patients who were taking their weekly dose correctly. The goal was to establish a normal patt…

This study aimed to find out how common joint pain and arthritis are among people living in nursing homes, including those with dementia. Researchers examined 100 residents to count painful or swollen joints and check their mobility. The goal was to gather better information to h…

This study looked at whether certain arthritis medications might increase the risk of developing cancer. Researchers analyzed health records from over 140,000 Swedish adults with rheumatoid or psoriatic arthritis who were taking various arthritis drugs. The goal was to understand…

This study aimed to understand why rheumatoid arthritis often improves during pregnancy while lupus sometimes gets worse. Researchers followed 50 pregnant women with these conditions to track tiny molecules in their blood called microRNAs. The goal was to find biological clues th…

This study aimed to understand how a specific gene, called matrix metalloproteinase-9 (MMP-9), is involved in rheumatoid arthritis. Researchers compared 60 people with active rheumatoid arthritis to a group of healthy individuals. The goal was to see if differences in this gene c…

This was a very early, small study to see how the body processes a new oral drug (SAR441566) being developed for rheumatoid arthritis. It tested single, increasing doses in 10 healthy Japanese male volunteers to check for safety and measure drug levels in the blood. The goal was …

This study aimed to understand why some people develop autoimmune rheumatic diseases like rheumatoid arthritis or lupus while their genetically similar siblings do not. Researchers enrolled over 1,000 participants, including sibling pairs where one was affected and one was health…

This study aimed to understand why people with rheumatoid arthritis (RA) and lupus have a much higher risk of heart attacks. Researchers collected blood samples from 176 participants, including patients and healthy volunteers, to analyze how inflammation might disrupt the body's …

This study tested a brief training program for rheumatologists (arthritis doctors) to see if it could help them provide more equal, high-quality care to Black and lower-income patients. The training focused on getting doctors to see each patient as an individual, rather than rely…

This was a small, completed lab study that tested whether specially engineered versions of a natural immune protein (called IL-2 muteins) could selectively boost a type of calming immune cell (regulatory T cells) taken from patients with various autoimmune and inflammatory diseas…

This study aimed to see if a simple 6-minute hand exercise test is a good way to measure upper body function in people with rheumatoid arthritis. Researchers tested 40 adult volunteers with the condition to check if the test was reliable and valid. The goal was to find a practica…

This early study tested a new potential rheumatoid arthritis drug called AZD6912 in 40 healthy volunteers. Researchers gave single injections at increasing doses to check for side effects and see how the body processes the drug. The main goal was to determine if the drug is safe …

This study looked at how doctors care for rheumatoid arthritis patients during virtual visits. Researchers first reviewed past telemedicine records to see how patients were assessed. Then, they tested whether having patients fill out a standard symptom questionnaire before their …

This study aimed to find out if measuring the amount of adalimumab (Humira) in a patient's blood can predict how well the drug will control their rheumatoid arthritis. Researchers followed 69 patients for 6 months, checking drug levels and disease activity markers. The goal was t…

This study aimed to understand how inflammation in rheumatoid arthritis affects heart disease risk. Researchers examined 74 adults with active rheumatoid arthritis who hadn't taken certain advanced medications. They measured blood flow to the heart to see if reducing inflammation…

This study aimed to better understand the link between gum disease (periodontitis) and rheumatoid arthritis. Researchers measured specific antibodies in the gums of 36 patients with both conditions before and after a standard gum cleaning treatment. The goal was to see if improvi…