RHEUMATOID ARTHRITIS

This study looked at whether two shingles vaccines, Zostavax and Shingrix, are safe and work well in people with rheumatoid arthritis (RA) who are taking the drug abatacept. About 154 adults with RA took part. Researchers measured immune responses and watched for side effects. Th…

This early-stage study tested a new drug called KD6005 in 73 people. First, healthy volunteers received a single dose to check safety. Then, people with rheumatoid arthritis received multiple doses. The main goal was to see if the drug is safe and how the body processes it. This …

This study tested an experimental drug called MP-435 combined with the standard medication methotrexate in 112 people with rheumatoid arthritis. The goal was to see if the combination could better control joint pain and swelling over 12 weeks. Participants were randomly assigned …

This study looked at 300 adults with active rheumatoid arthritis who did not respond well to their first anti-TNF medication. Researchers compared two strategies: switching to a different anti-TNF or changing to a biologic with a different mechanism of action (like abatacept, rit…

This study tested whether paroxetine, a drug usually used for depression, can help control rheumatoid arthritis when added to standard treatments. One hundred adults with active arthritis took part. The main goal was to see if their joint disease activity scores improved. The app…

This study tested a new drug called LY3871801 in 164 adults with moderate-to-severe rheumatoid arthritis, a condition causing painful, swollen joints. The goal was to see if the drug reduces disease activity and improves symptoms compared to a placebo. Participants had tried at l…

This study looked at the long-term safety and effectiveness of a drug called ABX464 in 40 people with moderate to severe rheumatoid arthritis. Participants took a 50mg daily dose as maintenance therapy after completing an initial 12-week treatment. The goal was to see if the drug…

This study tested whether rebamipide, a stomach-protecting drug, can help control rheumatoid arthritis when added to standard methotrexate therapy. Sixty adults with active arthritis took part. The goal was to see if the combination reduces joint pain and swelling better than met…

This study checked if switching from the original drug Remicade to its biosimilar Inflectra works just as well for patients with rheumatoid arthritis, spondyloarthritis, Crohn's disease, or uveitis. 262 adults who had already received at least three doses of Remicade were switche…

This study followed 155 adults in France with moderate to severe rheumatoid arthritis who were prescribed filgotinib. Researchers watched how long people stayed on the drug and how well it controlled their joint pain and swelling over two years. The goal was to see if filgotinib …

This early-stage study tested two versions of the drug ianalumab in 48 adults with active rheumatoid arthritis. The goal was to see if both forms are safe and work similarly in the body. Participants received multiple injections, and researchers monitored side effects and drug le…

This study compared two different knee replacement implants (Vanguard Cruciate Retaining and AGC Total Condylar) in 150 people with knee arthritis. The goal was to see which implant provides better pain relief and function after surgery. Participants were followed for several yea…

This study tested a smartphone app and monitoring system to help people with rheumatoid arthritis track their symptoms between doctor visits. A trained manager watched the data and alerted healthcare providers when disease activity increased. The goal was to improve patient satis…

This study tested a medical food called SBD121, which contains prebiotics and probiotics, to see if it helps manage symptoms of early rheumatoid arthritis. 143 adults with newly diagnosed RA took either the supplement or a placebo for 16 weeks. The main goal was to see if more pe…

This study tested two methods to help people with rheumatoid arthritis stop taking steroid medication (prednisone) safely. 102 adults with low disease activity or remission took part. One group slowly reduced their steroid dose, while the other switched to a different steroid (hy…

This early-stage study tested a new drug called SOL-116 in 56 healthy volunteers and people with rheumatoid arthritis. The main goal was to check if the drug is safe and how the body processes it. Researchers gave single or multiple doses and monitored for side effects. This is a…

This study tested the safety of a single IV infusion of a person's own fat-derived stem cells for active rheumatoid arthritis. Fifteen adults with active RA received the infusion and were monitored for side effects over 12 months. The main goal was to see if the treatment is safe…

This study tested whether increasing the dose of infliximab (a drug that blocks inflammation) helps people with active rheumatoid arthritis who were not getting enough relief from methotrexate alone. A total of 327 adults took part. Researchers measured improvements in joint pain…

This study looked at 322 adults with moderate-to-severe rheumatoid arthritis who were starting treatment with tocilizumab (Actemra/RoActemra). Researchers tracked their disease activity for 12 months to see how well the drug worked and how safe it was in real-world settings. The …

This study looked at whether the DASH diet (a heart-healthy eating plan) can help people with rheumatoid arthritis. 49 adults with active disease followed the diet for 12 weeks. Researchers measured inflammation, pain, and daily function to see if the diet could improve disease c…

This study looked at whether treating gum disease (periodontitis) can reduce the severity of rheumatoid arthritis (RA). Researchers enrolled 22 adults with both conditions. They compared standard RA care plus gum treatment to RA care alone. The goal was to see if gum treatment co…

This study tested a new daily medication called Proximod for people with moderate-to-severe rheumatoid arthritis who did not get enough relief from standard treatments. 179 participants took either a low or high dose of Proximod or a placebo for three months. The goal was to see …

This study tested whether adding cilostazol, a drug usually used for blood flow problems, to standard rheumatoid arthritis (RA) medicines can improve disease severity and quality of life. 70 adults with moderate to high RA activity took either cilostazol plus their usual RA drugs…

This study looked at how safe and effective a biosimilar version of infliximab (a drug that blocks inflammation) is for people with rheumatoid arthritis. 77 patients were treated and monitored for side effects and changes in disease activity. The goal was to gather real-world inf…

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis could switch from receiving infliximab through an IV drip at the hospital to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This early-stage study tested a new drug called EF-M2 in 48 adults with moderate-to-severe rheumatoid arthritis. The drug is designed to reprogram immune cells to reduce inflammation. The main goal was to check safety and how the body reacts to the drug, with a focus on finding t…

This study looked at over 9,000 people with rheumatoid arthritis to compare how well different treatments work in everyday life. Researchers compared drugs like TNF inhibitors and tofacitinib, taken alone or with methotrexate. The goal was to find which approach controls disease …

This study tested the drug filgotinib in 118 Korean adults with rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. The main goal was to see how many patients had at least a 20% improvement in symptoms after 12 weeks of treatment. The study is complet…

This early-stage study tested a single dose of a new drug called AZD6912 in 40 healthy adults to see if it is safe and how the body processes it. The drug is being developed to treat rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Since this was a…

This study tested a compound called 2-HOBA in 32 adults with rheumatoid arthritis to see if it is safe and reduces markers of inflammation. Participants took either 2-HOBA or a placebo three times daily for 4 weeks. The goal was to gather information for larger future studies, no…

This study tested whether MRI scans can help diagnose rheumatoid arthritis (RA) earlier in people with joint inflammation but no clear diagnosis. 75 adults with early symptoms were followed for a year. The goal was to see if MRI findings could predict who would develop RA, allowi…

This study tested whether a mobile app designed for people with rheumatoid arthritis can improve quality of life and reduce disease activity. 90 adults with stable rheumatoid arthritis used the app for 12 weeks or received routine care. The app provided evidence-based recommendat…

This study tested if kinesiologic taping (a special elastic tape placed on the knee) can reduce pain, improve movement, and lessen fear of moving in people with knee rheumatoid arthritis. Thirty adults aged 45-60 were split into two groups: one got the real tape, the other got a …

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, or lupus. Participants received coaching over the phone to help them walk more and manage symptoms. The goal was to see if this approach could reduce pain and …

This study tested a hand exercise program called SARAH in 6 women with rheumatoid arthritis. The program includes strengthening, stretching, and home exercises plus education. The goal was to see if it improves hand function and reduces pain. Results may help guide physical thera…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration adalimumab injection. Researchers measured injection site pain and how well patients stuck with the new treatment over 180 days. The…

This study tested whether injecting etanercept directly into inflamed joints (knee, wrist, ankle, elbow) can safely ease pain in people with rheumatoid arthritis. 34 adults with at least 6 months of RA and a painful flare lasting 2 weeks or more took part. The goal was to compare…

This study tested a program called OPERAS for people with rheumatoid arthritis. Participants used a web app to track symptoms and medication, and received remote coaching from a physiotherapist using a Fitbit. The goal was to see if this approach helps people feel more confident …

This study looked at 69 people with rheumatoid arthritis taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if higher concentrations led to better symptom control. The goal was to find a target level that could help doctors adj…

This study looked at 74 adults with active rheumatoid arthritis (RA) who had never taken biologic drugs. Researchers used heart scans to measure how well the heart's blood vessels work, aiming to understand if reducing inflammation lowers heart risk. The goal was to learn whether…

This study looked at whether using a computer to guide knee replacement surgery leads to better results than the traditional method done by hand. About 192 patients aged 50 to 85 with knee arthritis took part. Researchers tracked how long the new knee lasted, how well it worked, …

This study looked at how methotrexate, a key rheumatoid arthritis drug, is removed from the body in patients who take it as prescribed. Researchers measured the drug and its main byproduct in urine from 62 patients. The goal was to create a standard reference to help doctors iden…

This early-stage study tested a new oral drug called SAR441566 in 10 healthy Japanese men to see how the body processes it and if it is safe. The drug is being developed for rheumatoid arthritis, but this study did not treat the disease. Participants took single increasing doses …

This study tested whether ultrasound can detect early signs of rheumatoid arthritis (RA) returning in patients treated with rituximab, before they feel symptoms. Thirty adults with RA who had not responded to other treatments took part. The goal was to see if ultrasound could pre…

This study tested whether a short-chain fatty acid (SCFA) supplement, taken by mouth, could change gut bacteria and immune responses in people with rheumatoid arthritis (RA) who did not get enough help from methotrexate. About 20 to 35 adults with RA took the supplement for one t…

This study looked at why people with rheumatoid arthritis (RA) often miss out on cholesterol checks and treatments that can prevent heart attacks and strokes. Researchers worked with 101 adults aged 40-75 who have RA but were not taking cholesterol-lowering medication. The goal w…

This study looked at 86 people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis to see if air pollution triggers flare-ups. Participants reported their symptoms weekly for 6 months, while researchers measured their exposure to pollutants based on where th…

This study looked at whether cutting back on salt can lower inflammation and blood pressure in people with rheumatoid arthritis. Researchers measured changes in tissue sodium using MRI and tracked disease activity scores. The study involved 18 adults with stable, moderate arthrit…

This study tested whether a non-invasive ultrasound device can reduce inflammation in people with psoriatic arthritis, rheumatoid arthritis, or ankylosing spondylitis. Sixteen participants received four ultrasound sessions, one of which was a sham (placebo). The main goal was to …

This study looked at how well the G7 hip socket implant works in 162 people with arthritis or other hip joint problems. Researchers measured pain, movement, and daily function using standard hip scores, and also checked X-rays. The goal was to see if the implant performs well in …

This study involved 70 people with rheumatoid arthritis to see how telemedicine affects their care. Researchers tracked whether virtual consultations led to in-person visits, hospital stays, or changes in medication. The goal was to understand how to best use telemedicine for man…

This study tested whether a visit with a nurse to check for related health issues (like heart disease or infections) and a program teaching patients to score their own arthritis activity could improve care. About 970 adults with stable rheumatoid arthritis took part. The goal was…

This study looked at how core endurance, finger grip strength, fatigue, and hand function are connected in people with rheumatoid arthritis (RA). Researchers compared 113 participants, including those with RA and healthy controls. They measured core endurance with a modified plan…

This study looked at how rheumatoid arthritis (RA) affects arm exercise ability, hand grip strength, and everyday activities like reaching and carrying. Researchers tested 26 adults with RA using simple physical tests and questionnaires. The goal was to better understand these li…

This study looked at how the rheumatoid arthritis drug tofacitinib changes body composition—like fat, muscle, and bone density—in 10 patients. Researchers measured changes in belly fat and bone marrow fat over time. The goal was to gather early data, not to test if the drug works…

This study looked at whether a simple test called the six-minute pegboard and ring test (6-PBRT) is a good way to measure arm exercise ability in people with rheumatoid arthritis. Forty adults with the condition did the test, along with other arm strength and function tests. The …

This study checked whether a new oral drug for rheumatoid arthritis, SAR441566, makes healthy adults more sensitive to sunlight or UV light. Sixty participants aged 18 to 55 received either the drug, a placebo, or a known sun-sensitizing antibiotic. Researchers measured skin redn…

This study looked at whether taking daily vitamin D or fish oil supplements could reduce the risk of autoimmune diseases, lower inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or heart disease took part. Researchers measured inflamma…

This study looked at 60 people with rheumatoid arthritis and 30 healthy volunteers to measure differences in a gene called MMP-9, which makes an enzyme that can break down joint tissue. Researchers wanted to understand how this gene might contribute to joint damage in arthritis. …

This study looked at 36 adults with rheumatoid arthritis to see if the severity of their gum disease was linked to levels of certain antibodies (ACPAs) in their gum fluid. Researchers measured these antibodies before and after non-surgical gum treatment. The goal was to better un…

This study looked at why people with rheumatoid arthritis (RA) and lupus have a higher chance of heart attacks. Researchers examined blood samples from 176 adults to see how immune system changes affect cholesterol buildup in cells. The goal was to understand the link between the…

This study looked at whether regular check-ins by a nurse could detect early signs of rheumatoid arthritis (RA) flare-ups in patients taking the drug rituximab. Researchers followed 51 adults with RA who were in remission or had low disease activity. The goal was to see if nurse …

This study looked at whether a program that helps doctors and patients make decisions together can improve outcomes for veterans with rheumatoid arthritis. About 900 veterans took part across multiple VA clinics. The goal was to see if this approach lowers disease activity, boost…

This study looked at whether using a robot (the ROSA system) during knee replacement surgery leads to more accurate implant placement than traditional methods. It involved 252 adults with knee pain from arthritis or other conditions. The main goal was to compare alignment accurac…

This study looked at whether natural plant estrogens (phytoestrogens) in food might be a risk factor for lupus flares. Researchers measured phytoestrogen levels in blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or healthy controls. The goa…

This study tested a short training for rheumatologists to help them focus on each patient's individual needs, aiming to reduce unconscious bias. Researchers looked at whether this training improved the quality of care for Black and lower-income patients with conditions like lupus…

This study looked at whether a deep dental cleaning (called nonsurgical periodontal therapy) can lower inflammation and improve quality of life in 20 adults who have both rheumatoid arthritis and gum disease. Researchers measured changes in blood markers, bacteria in the mouth, a…

This study looked at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compared their blood cells, genes, and environmental exposures to find clues about why one got sick. Over 1,000 people took part, inclu…

This study looked at 50 pregnant women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) to see if changes in microRNAs (tiny molecules that control genes) during pregnancy are linked to disease activity. Researchers collected blood, urine, and placenta samples…

This study looked at how often nursing home residents over 65 have joint complaints like pain or swelling. Researchers examined 100 residents, some with dementia and some without, to count tender or swollen joints. The goal was to better understand these issues in a group that is…

This study looked at the safety of the drug abatacept in over 140,000 people with rheumatoid arthritis or psoriatic arthritis in Sweden. Researchers tracked how many people developed different types of cancer while taking abatacept or other arthritis medications. The goal was to …

This study tested specially engineered versions of a natural immune protein (IL-2) in blood samples from 67 people with autoimmune or inflammatory diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal was to see if these modified proteins could selectively a…