RHEUMATOID ARTHRITIS

This study tests whether a team of pharmacists and doctors working together can help people with rheumatoid arthritis take their medications as prescribed. About 200 adults with RA will be split into two groups: one gets this collaborative care starting in the hospital and contin…

This study tests a new treatment called anti-CD19/BCMA universal CAR-T cells for people with severe autoimmune diseases like lupus, scleroderma, and rheumatoid arthritis that haven't responded to standard therapies. The treatment uses specially engineered immune cells to target a…

This study looks at the long-term safety and effectiveness of the drug TLL-018 in people with rheumatoid arthritis who have already finished a previous trial. About 350 adults aged 18 to 75 will take part. The goal is to see how well the drug controls arthritis symptoms over time…

This study tests a new treatment order for people with rheumatoid arthritis who still have active disease despite standard medications. Participants will either receive a TNF inhibitor followed by abatacept, or TNF inhibitors alone. The goal is to see if the two-step approach lea…

This study tests whether taking fecal transplants (processed stool from healthy donors) in capsule form can help control inflammation in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hund…

This study tests whether adding an anti-inflammatory diet to standard care can improve rheumatoid arthritis symptoms. Researchers will enroll 124 adults with low to moderate disease activity. Participants will follow the diet for a period, and the study will measure changes in di…

This early-stage study tests a new medicine, SR-878, in 27 adults with rheumatoid arthritis. The goal is to find a safe dose by checking for side effects. Participants will take the drug and be monitored for about 16 weeks.

This study tests whether baricitinib, a JAK inhibitor, can repair bone damage in people with active rheumatoid arthritis (RA). About 60 adults with RA and visible bone erosion will receive either baricitinib or a placebo for 24 weeks. Researchers will use special CT scans to see …

This early-stage trial tests a new treatment called AZD0120, which uses a patient's own immune cells modified to target and calm overactive immune responses. It is for adults with systemic sclerosis, inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. The main go…

This study tests three new treatments for adults with moderate-to-severe rheumatoid arthritis (RA) who have not responded well to at least one prior therapy. About 180 participants will receive either a single drug (lutikizumab or ravagalimab), a combination of both, or a placebo…

This early-stage study tests a new medicine called surovatamig in 48 adults with rheumatoid arthritis or lupus. The main goal is to check if the drug is safe and tolerable, and how the body processes it. Participants receive increasing doses to find the best and safest level.

This early-stage study tests the safety of a new drug called CPTX2309 in healthy people and those with moderate to severe rheumatoid arthritis or lupus. Researchers will give the drug through a vein and watch for side effects, changes in lab tests, and how the body responds. The …

This study tests whether combining two drugs, telitacicept and baricitinib, can help people with difficult-to-treat rheumatoid arthritis (D2T RA) who have not responded to other treatments. About 30 adults aged 18-85 will receive the combination and be monitored for joint disease…

This early-stage study tests a new treatment called HN2301 in 30 people with autoimmune diseases like lupus, scleroderma, or rheumatoid arthritis. The main goal is to check safety and find the right dose. Researchers will also look at how well the therapy works and how the body r…

This study tests a new drug called Afimkibart for people with moderate to severe rheumatoid arthritis who have not gotten better with or cannot tolerate common treatments like TNF or JAK inhibitors. About 160 participants will receive either the drug or a placebo to see if it red…

This study is testing a knee implant called Persona in 760 people who need knee replacement surgery due to arthritis or other knee problems. The goal is to see if the implant is safe, works well, and helps patients move better and feel less pain. Participants will be followed for…

This study tests a new drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't responded well to other treatments. The goal is to see if the drug reduces joint swelling and pain over 12 weeks. Participants will receive either AZD1163 or a placeb…

This study looks at whether adding a statin to tofacitinib can lower the chance of serious heart problems in people with rheumatoid arthritis. It involves 120 adults aged 50 or older who have at least one heart risk factor. The goal is to see if this combination is safer for the …

This study checks if a surgical robot called ROSA Knee can help surgeons make last-minute changes to a knee replacement plan based on how the patient's soft tissues look during the operation. About 80 adults with knee arthritis will take part and be followed for two years. The go…

This study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo to see if it reduces joint pain, swelling, and inflamm…

This study is testing a silicone joint implant called KeriFlex® for people with arthritis in the hand (rheumatoid, degenerative, or traumatic). The goal is to see if the implant improves hand function and is safe over time. About 86 adults who need joint replacement in the finger…

This study tests whether a new drug called CIT-013 can reduce disease activity in adults with moderately active rheumatoid arthritis. About 88 participants will receive either CIT-013 or a placebo every two weeks for six weeks. Researchers will check joint swelling, pain, and saf…

This study tests a new treatment using specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells in people with severe autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma. About 72 adults will receive the cells in increasing doses to f…

This early-stage study tests whether a new drug called AZD5492 is safe and tolerable in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive either one or two doses under the skin and are monitored for side effects and drug levels over 6 months. The goal …

This study tests a new drug called SBT777101 in 24 adults with moderate-to-severe rheumatoid arthritis (RA) who have not responded well to other treatments. It is the first time this drug is given to humans, so the main goal is to check its safety and side effects at different do…

This study tests whether pentoxifylline, an anti-inflammatory drug, can help control rheumatoid arthritis. About 50 adults with active arthritis who are already on standard medications will receive pentoxifylline. The main goal is to see if it lowers disease activity scores.

This early-phase study tests a new treatment called CC-97540, which uses a person's own immune cells (CAR T cells) to target and calm the overactive immune system in severe autoimmune diseases like lupus, myositis, scleroderma, and rheumatoid arthritis. The goal is to see if it i…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study tests whether regularly measuring drug levels in the blood (therapeutic drug monitoring) can help adults with rheumatoid arthritis maintain disease control and avoid flares. 350 participants on a standard arthritis medication will be followed for 18 months. Half will h…

This early-stage study tests a new medicine called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. About 63 participants will be followed for up to a year. This is not a cure; it ai…

This study looks at people with active rheumatoid arthritis who have a specific pattern in their joint tissue (called myeloid-stromal) that often leads to worse outcomes. Researchers want to see if starting treatment with two drugs—methotrexate and tofacitinib—works better than m…

This study tests whether adding roflumilast (a lung drug) or desloratadine (an allergy drug) to standard rheumatoid arthritis treatment can better control the disease. About 90 adults with active arthritis will take one of these medicines or a placebo for 12 weeks. Researchers wi…

This early-stage study tests a new drug called PIT565 in people with rheumatoid arthritis (RA). The main goal is to check if the drug is safe and how the body processes it. About 57 adults with RA will take part. The study is open-label, meaning everyone knows they are getting th…

This study is testing whether taking vitamin E supplements for one month can help reduce inflammation and ease symptoms in people with rheumatoid arthritis. Researchers will compare vitamin E against a placebo (inactive pill) in 46 female participants who have early-stage rheumat…

This study looks at whether a quick, safe, and cheap lung ultrasound can detect lung scarring (interstitial lung disease) in people with rheumatoid arthritis. About 280 adults with rheumatoid arthritis and risk factors for lung disease will get an ultrasound, and the results will…

This study tests an online health program that teaches diet and self-care habits to 200 adults with conditions like rheumatoid arthritis, lupus, or psoriatic arthritis. The goal is to see if the program can reduce fatigue and improve quality of life. Participants will complete su…

This pilot study tests whether a supervised, at-home exercise program combining aerobic and strength training is feasible and safe for 15 people recently diagnosed with rheumatoid arthritis (within 6 months). Participants will do the exercises remotely, and researchers will measu…

This early-stage study tests a new drug called GS-0151 in 75 adults with rheumatoid arthritis. The main goal is to check if the drug is safe and how the body processes it. Participants receive multiple doses of the drug or a placebo, and researchers monitor side effects and drug …

This early-stage study tests a new drug called LFD-200 in healthy volunteers and people with moderate to severe rheumatoid arthritis (RA). The main goal is to see if the drug is safe and how the body processes it. Researchers will give single or multiple doses and watch for side …

This early-stage study tests a new drug called plamotamab in 68 adults with moderate to severe rheumatoid arthritis who have not responded well to other treatments. The main goal is to check the drug's safety and side effects when given as an injection under the skin. Researchers…

This early-stage study tests a new medicine called MK-1045 in about 21 people with lupus or rheumatoid arthritis. The main goal is to check if the drug is safe and well-tolerated at different doses. Researchers will also measure how the drug moves through the body. This is a Phas…

This study is testing a new data platform called Pheno4U in 600 people receiving a total knee replacement. Participants will use a smartphone app and a sensor to track their recovery. The goal is to identify unknown risks or side effects and improve patient care.

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study looks at 750 adults with rheumatoid arthritis (RA) who are at risk for interstitial lung disease (ILD). Researchers use CT scans and other tests to find early signs of lung damage and figure out who might get worse over time. The goal is to better understand the diseas…

This study is for adults with rheumatoid arthritis whose current treatments have stopped working. Researchers want to learn how to match each patient to the most effective drug for them, using advanced computer analysis and health data. The goal is to make treatment more personal…

This study looks at how accurately surgeons can place a new hip cup using a non-invasive navigation system during total hip replacement. About 118 adults with hip conditions like arthritis or avascular necrosis will take part. The goal is to see if the system helps achieve the pl…

This study will follow 200 adults with refractory rheumatoid arthritis (RA) in China. Refractory RA means the disease stays active even after standard treatments. The goal is to understand why some people don't respond to therapy, identify key markers, and find better treatment a…

This study looks at why people with rheumatoid arthritis (RA) often have trouble controlling high blood pressure, which raises their risk for heart disease. Researchers will work with 25 adults who have both conditions to test a program that helps them monitor their blood pressur…

This study looks at how people with fibromyalgia or rheumatoid arthritis experience pain differently. Researchers will measure pressure pain thresholds in 150 adults to compare pain processing in these conditions. The goal is to better understand pain mechanisms, which could lead…

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease). The tool helps patients understand immune checkpoint inhibitor drugs and their possible side effects. Researchers wil…

This study looks at whether adding a family doctor to a rheumatology team can improve care for other health issues in people with rheumatoid arthritis. About 199 adults with rheumatoid arthritis will have their vaccination, heart, and bone health checked by a special family docto…

This study looks at whether adding breathing muscle training to standard rehab helps people with rheumatoid arthritis who also have lung disease. Researchers will check changes in exercise ability, breathlessness, and a specific gene (HOTAIR). About 39 adults will take part, and …

This study aims to understand how well shoulder replacements work over the long term by following up to 20,000 people for at least 10 years. Participants include those who have already had or are scheduled for shoulder replacement due to conditions like arthritis, rotator cuff te…

This study is a registry that will enroll up to 1,000 pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will collect information to identify risk factors for poor pregnancy outcomes. The goal…

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This study looks at whether rheumatoid arthritis patients taking the drug baricitinib have more nerve damage than those on standard treatments. Researchers will use nerve conduction tests to measure how well nerves work. The goal is to better understand the risk of peripheral neu…

This study looks at how a drug called abatacept (Orencia) changes immune cells in people with rheumatoid arthritis. Researchers will compare patients starting abatacept, those on other treatments, and healthy volunteers. The goal is to understand why joints swell and hurt, and to…

This study follows 200 adults with rheumatoid arthritis who are in stable remission on standard medications. Researchers will track their health over up to 5 years using exams, ultrasound, and X-rays to see who stays well and who has a flare. The goal is to better understand remi…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biological markers that can predict how well a patient will respond to…

This study looks at 200 adults with rheumatoid arthritis to understand why some people feel worse when they slowly reduce their steroid medication (like prednisone), while others do fine. Researchers will measure inflammation, brain activity, and hormone levels to find clues. The…