RHEUMATOID ARTHRITIS

This study compares two different treatment goals for managing rheumatoid arthritis (RA). It tests whether aiming for a state of remission is better than aiming for low disease activity when adjusting medications. The trial involves 340 people with RA to see which strategy leads …

This study follows over 1,300 adults with moderate to severe rheumatoid arthritis who are taking filgotinib medication. Researchers are observing how well the drug controls symptoms, how long patients stay on it, and what side effects occur in everyday practice. The goal is to un…

This study is testing an experimental drug called LY3541860 for adults with moderate-to-severe rheumatoid arthritis who haven't responded well to other advanced treatments. About 35 participants will receive the drug for 24 weeks, followed by 20 weeks of safety monitoring. Resear…

This study is testing whether a small implanted device that stimulates a nerve in the neck can help control moderate-to-severe rheumatoid arthritis. It is for adults whose arthritis hasn't improved enough with other strong medications. About 250 participants will have the device …

This early-stage study aims to check the safety and side effects of a new drug called GS-0272 in adults with rheumatoid arthritis. Researchers will give different doses to about 55 participants to see how the body handles the drug and if it causes any problems. The main goal is t…

This study is tracking how well Persona knee replacement implants perform over time in people with severe knee arthritis. Researchers are following 737 patients for up to 10 years after surgery to see how long the implants last and how much pain relief and improved function they …

This study is observing 600 people with moderate to severe rheumatoid arthritis who are already prescribed a medication called Tyenne. Researchers will follow these patients for 12 months to see how many continue taking the drug and if their arthritis symptoms improve. The goal i…

This study follows people who received Zimmer ankle replacement implants to see how well they work over 10 years. Researchers will track 120 adults with severe ankle arthritis to monitor pain relief, function improvement, and whether the implants need replacement. Participants wi…

This study is tracking a specific knee replacement implant over 10 years to see how well it reduces pain, improves mobility, and lasts inside the body. It involves about 300 adults with severe knee arthritis who receive the implant. Researchers will check in regularly using X-ray…

This study is monitoring how well a specific hip replacement implant, called MiniMAX, performs in real patients after it has been approved for use. It will follow 100 adults who need a total hip replacement due to conditions like arthritis or injury. Researchers will track how lo…

This study is following 240 people for 10 years after they receive a specific brand of personalized knee replacement. Researchers want to see how safe the implant is and how well it relieves pain and improves movement for people with severe knee arthritis. The study tracks patien…

This study compares two medications, upadacitinib and adalimumab, for adults with moderate to severe rheumatoid arthritis who didn't respond well to a previous TNF inhibitor drug. About 480 participants worldwide will take one of the two drugs along with their current methotrexat…

This study is collecting long-term data on a set of replacement implants for the upper arm, including the shoulder and elbow. It aims to see how well these devices work and how safe they are for people with severe joint damage from conditions like arthritis, injury, or cancer. Th…

This study follows 200 patients who receive GMK Sphere cementless knee implants to see how well they perform over time. Researchers will track how long the implants last, measure pain and mobility improvements, and monitor for any complications. The goal is to gather real-world d…

This study is observing adults in France with moderate to severe rheumatoid arthritis who are starting treatment with the drug filgotinib. Researchers will follow 155 patients for two years to see how well the drug controls their disease, how safe it is, and how it affects their …

This study is tracking how well a new type of shoulder replacement implant works over time. It follows 152 patients with severe shoulder arthritis who received the implant, checking their pain, movement, and quality of life for up to 10 years after surgery. The main goal is to co…

This early-stage study is testing whether a personalized cell therapy called CAR-T (KYV-101) can work better than the standard drug rituximab for people with severe, treatment-resistant rheumatoid arthritis. It will enroll 13 patients to compare the safety of both treatments and …

This study is for people with rheumatoid arthritis (RA) who haven't gotten enough relief from their current biologic or targeted drugs. It's testing if taking two powerful medications together—baricitinib and an anti-TNF drug—works better to control the disease than taking just b…

This study is testing whether an experimental drug called IMVT-1402 can help control rheumatoid arthritis in adults whose disease hasn't responded well to other treatments. About 120 participants will receive the drug or a placebo to see if it reduces joint swelling and pain. The…

This study is tracking the safety and performance of a specialized metal plate used to fix broken shoulders. It will follow 135 adults who get this plate after a shoulder fracture to see how well they heal, how much their shoulder moves, and if they need another surgery. The main…

This study is testing how well a new knee replacement system works for patients who need a second or revision surgery. It's for people whose first knee replacement failed or who have severe arthritis, deformity, or pain. Researchers will track how well the new implant improves pa…

This study is observing how well a new hip replacement system works and how safe it is for patients with severe hip arthritis or similar conditions. It will follow 230 patients who receive the implant to see how long it lasts and how much it improves their pain and mobility. The …

This early-stage study aimed to test the safety and find the right dose of an experimental drug called F8IL10, given as injections directly into inflamed joints of people with rheumatoid arthritis. The trial was designed for patients whose arthritis flared up despite being on sta…

This study is monitoring a specific shoulder replacement system to see how safe and effective it is over ten years. It involves about 67 patients in Europe who have received the implant for conditions like severe arthritis, rotator cuff tears, or fractures. Researchers are tracki…

This study is testing how well the drug filgotinib works and how safe it is for Korean adults with rheumatoid arthritis who haven't gotten enough relief from other standard medications. About 118 participants will take filgotinib for 24 weeks, and researchers will measure improve…

This study is collecting long-term information on a commercially available shoulder replacement system. It will follow 110 patients who have received the implant for conditions like severe arthritis, fractures, or rotator cuff tears. The main goal is to monitor how well the devic…

This study is checking how well a specific cemented hip replacement part works and how safe it is over time. It follows 119 patients who have already received this implant for their hip arthritis or injury. Researchers will measure their pain, ability to walk and do daily activit…

This study is tracking how well a specific type of shoulder replacement implant works over time. It involves 200 adults with severe shoulder problems like arthritis or complex fractures who need a 'reverse' shoulder replacement. Researchers will follow patients to see how long th…

This study follows patients for up to 10 years after hip replacement surgery to check the long-term safety and performance of a specialized implant liner. The liner is designed for patients at high risk of their hip dislocating, such as those with severe arthritis, certain hip fr…

This study is testing an experimental pill called LNK01001 for people with moderate-to-severe rheumatoid arthritis whose symptoms aren't controlled by other powerful injectable medications. About 430 participants will take either the new drug or a placebo pill for 24 weeks, follo…

This study compares two types of knee replacement implants—one that uses bone cement and one that doesn't—to see which provides better long-term results. Researchers will follow 300 patients with severe knee arthritis for up to 5 years after surgery, measuring pain levels, knee f…

This early-stage study is testing a single intravenous infusion of stem cells derived from umbilical cords (called BC-U001) in people with rheumatoid arthritis. The main goal is to see if the treatment is safe and to find the right dose. It is for patients whose arthritis remains…

This study is testing whether a special education program helps people with rheumatoid arthritis manage their condition better. 88 participants will either join the 6-month program with group sessions and individual activities or receive usual care. Researchers will check if the …

This study is testing whether gentle, low-frequency electromagnetic waves can help stabilize the immune system and reduce painful flare-ups in people with autoimmune diseases like lupus, rheumatoid arthritis, and multiple sclerosis. About 120 participants will receive either real…

This study is testing different ways to help people with inflammatory arthritis who face life challenges like unstable housing or transportation issues that make it hard to get medical care. It compares three levels of support: a simple resource list, help from a community specia…

This study is testing if a new, single auto-injector pen delivers the same amount of the drug ianalumab into the body as two separate pre-filled syringes. It involves 155 adults with rheumatoid arthritis, lupus, or Sjögren's disease. The main goal is to see if the drug levels in …

This study aimed to see if taking a small tissue sample from an inflamed joint could help doctors predict which biologic medication would work best for a patient with rheumatoid arthritis. It focused on adults whose arthritis wasn't controlled by standard pills, hoping to match t…

This study aims to find out if two shingles vaccines, Zostavax and Shingrix, are safe and work well for people with rheumatoid arthritis who are taking the medication abatacept. It will enroll about 154 adult participants who are already on this treatment. Researchers will measur…

This study is checking if the Shingrix shingles vaccine is safe and works well for people with autoimmune rheumatic diseases like lupus or rheumatoid arthritis. These patients are at high risk for shingles but are often on medications that weaken the immune system. Researchers ar…

This study aims to see if a specific set of foot and leg exercises, taught and monitored through video calls (telerehabilitation), can help people with rheumatoid arthritis. Researchers want to know if these exercises can reduce foot pain, improve walking stability, and make dail…

This study follows 777 adults who received Persona brand knee replacements for severe arthritis pain. Researchers will track how well the implants work and how long they last over 5-10 years. The goal is to collect real-world data on pain relief, joint function, and quality of li…

This study is testing whether a 12-week program of high-intensity interval training (HIIT) can help people with rheumatoid arthritis. Researchers want to see if this type of exercise improves heart and blood vessel function, reduces body-wide inflammation, and helps with symptoms…

This remote study aimed to provide holistic education and pastoral counseling to help people manage stress and improve wellness in daily life. It was designed for specific unmarried Alaska Medicaid recipients who met religious and lifestyle criteria. The study was withdrawn befor…

This study collects existing medical records to understand how well shoulder replacement implants perform over time. Researchers are gathering data on 160 patients who already received these approved implants to track how long they last and monitor any safety issues. No new treat…

This study aimed to gather information on pregnancy in women with rare autoimmune diseases like lupus and rheumatoid arthritis. Researchers planned to follow these pregnancies to understand complications and how treatments affect both mother and baby. The goal was to use this inf…

This registry collects information about how well rheumatoid arthritis medications work and what side effects patients experience in real-world settings. It follows over 90,000 patients during their regular doctor visits to track their treatment experiences over time. The study d…

This study is a large registry that observes 2000 Japanese patients with rheumatoid arthritis to understand how well different approved medications work and how safe they are in everyday practice. It does not test new treatments but collects information from patients and their do…

This study is collecting blood samples from thousands of rheumatoid arthritis patients to build a research bank. Participants are already enrolled in arthritis registries and are starting new medications. The samples will be used to study disease patterns, predict treatment respo…

This study analyzed existing Medicare and Medicaid data from 1999 to 2015 to understand how often people with rheumatoid arthritis and ankylosing spondylitis undergo major orthopedic surgeries like joint replacements. Researchers examined whether surgery rates have changed over t…

This study aimed to learn how the bodies of obese adults and children with arthritis process the drug etanercept. Researchers wanted to measure drug levels in the blood and see how body weight influences the drug's effectiveness, with the goal of finding the right dose. The study…

This study aims to better understand the heart, lung, and mental health risks faced by people with rheumatoid arthritis. It will follow 4,000 participants for up to 10 years, using heart scans, lung tests, questionnaires, and blood samples. The goal is to learn how to spot these …

This study is observing 1600 people with rheumatoid arthritis over many years to learn more about the disease. Researchers are collecting health information and blood samples to try to find markers that can predict how severe the arthritis will get and how well treatments will wo…

This study aims to understand how genetics, lifestyle, and other factors influence the progression and severity of many common chronic diseases. Researchers will collect health records, genetic data, and samples from 120,000 participants with conditions like diabetes, arthritis, …

This study aims to understand how normal aging affects the way doctors measure disease activity, thinking skills, and physical ability in people with rheumatoid arthritis (RA). Researchers are comparing 420 RA patients with 420 people without RA, all aged 55-85, to create age-spe…