RHEUMATOID ARTHRITIS

This study compares two types of total knee replacements: one that uses bone cement to hold the implant in place and one that does not. The goal is to see which approach provides better pain relief, function, and implant survival over time. About 300 people with knee pain from ar…

This study follows 200 adults getting a shoulder replacement with the Zimmer Trabecular Metal Reverse Shoulder System. It aims to see how long the implant lasts and how well it relieves pain and improves function in people with arthritis, fractures, or failed prior shoulder repla…

This study follows 313 people who received the Insignia Hip Stem during total hip replacement surgery to see how well the implant works and how safe it is over 10 years. Participants have conditions like hip arthritis, avascular necrosis, or fractures. The main goals are to measu…

This early-stage study tests a new drug called CND261 in 47 adults with moderate-to-severe rheumatoid arthritis who haven't responded well to other treatments. The main goal is to check the drug's safety and how the body handles it. Researchers will also look for signs that the d…

This study compares two common treatment strategies for rheumatoid arthritis (RA) to see which one works better at controlling the disease. About 340 adults with RA will be assigned to aim for either low disease activity or remission, using standard measures. The goal is to find …

This study tests a new drug called TLL-018 against an approved drug, tofacitinib, in people with active rheumatoid arthritis who did not get enough relief from or could not tolerate biologic treatments. About 459 adults aged 18–65 will take either TLL-018 or tofacitinib for sever…

This study follows 110 people who receive the Tornier HRS shoulder replacement system to see how well it improves pain and function over time. Participants have conditions like arthritis, fractures, or rotator cuff tears. The goal is to collect safety and performance data for reg…

This study follows 737 people who received a Persona knee replacement to see how well the implant works over time. Participants had severe knee pain from conditions like arthritis or injury. The goal is to measure implant survival and improve knee function.

This study looks at how well a new knee replacement system works for people with painful knee conditions like arthritis or previous knee surgery failure. About 255 participants will get the new system and be followed for up to 10 years. The goal is to see if it improves knee alig…

This phase 3 trial tests whether adding an anti-TNF drug to baricitinib works better than baricitinib alone for people with rheumatoid arthritis who haven't responded well to previous treatments. About 160 adults with active RA will receive either the combination or baricitinib a…

This study follows 67 people who received a T.E.S.S. V3 shoulder implant to treat conditions like arthritis, fractures, or rotator cuff tears. Researchers will check how long the implant lasts and track any side effects over 10 years. The goal is to confirm the device is safe and…

This study follows 100 people who need a hip replacement to see how well the MiniMAX hip stem works. Participants receive the stem during surgery and are monitored for survival and hip function using the Harris Hip Score. The goal is to confirm the device performs safely and effe…

This study looks at a specific cemented hip stem used in hip replacement surgery. About 119 adults with hip problems like arthritis or fractures will be followed for 5 years. Researchers will measure pain, function, and any issues to make sure the device works well and is safe in…

This study tests an experimental oral drug called LNK01001 (Zemprocitinib) in adults with moderate-to-severe rheumatoid arthritis who have not responded well to biologic treatments. About 430 participants will receive either the drug or a placebo for 24 weeks, followed by a longe…

This study follows over 1,300 adults with moderate to severe rheumatoid arthritis who are taking filgotinib as part of their normal care. Researchers want to see how long patients stay on the drug and how it affects pain, fatigue, and daily life. The goal is to understand the dru…

This study compares two ways of giving the drug ianalumab to adults with rheumatoid arthritis, Sjögren's disease, or lupus. One group gets one injection from a 2mL auto-injector, the other gets two separate 1mL shots. The goal is to see if the single injection works just as well …

This early-stage study tests the safety and tolerability of a new drug called GS-0272 in 55 adults with rheumatoid arthritis. Participants receive multiple doses of the drug or a placebo to see how the body handles it and whether it causes side effects. The goal is to gather init…

This study follows 777 people aged 18-75 who received a Persona knee implant to treat severe knee pain or disability from conditions like osteoarthritis or rheumatoid arthritis. Researchers are checking how long the implant lasts, how safe it is, and how well it improves pain and…

This study compares two approved drugs, upadacitinib (a pill) and adalimumab (an injection), in adults with moderate to severe rheumatoid arthritis who have already tried one TNF inhibitor without success. About 480 participants will be randomly assigned to one of the two treatme…

This study tests a small device implanted on the vagus nerve in the neck to treat moderate to severe rheumatoid arthritis. About 243 adults who haven't improved with other drugs will receive either active or inactive stimulation for 12 weeks, then all will get active stimulation …

This study tests an experimental drug called BGB-45035 in 49 adults with moderate to severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. Participants are randomly assigned to receive either the drug or a placebo, and researchers measure changes …

This study follows about 600 adults with moderate to severe rheumatoid arthritis who are already prescribed Tyenne, a biosimilar of tocilizumab. Researchers want to see how long patients stay on the treatment over 6 and 12 months. The study does not test a new drug but observes r…

This early-stage study tests a one-time intravenous infusion of stem cells from donated umbilical cords in 9 adults with moderate-to-severe rheumatoid arthritis who haven't responded well to standard treatments. The main goal is to check safety and tolerability, while also lookin…

This study looks at how well a knee replacement system works for people with arthritis or knee damage. About 299 patients received the implant to see if it reduces pain and helps them move better. The goal is to show that the implant lasts and improves daily life.

This study is testing a new system for replacing failed joint implants in 105 people with conditions like arthritis, bone tumors, or previous implant failure. The main goal is to see how long the new implants last without needing another replacement. Researchers will also measure…

This study is checking how well a special hip implant liner works and how safe it is over time. It includes 202 people aged 18 to 80 who need a hip replacement due to conditions like arthritis, fractures, or hip dislocation. The main goal is to see how long the implant lasts with…

This study follows 120 adults with arthritis (degenerative, rheumatoid, or post-traumatic) who received a Zimmer Trabecular Metal Total Ankle implant. Researchers track how long the implant lasts and how well it improves pain and function over 10 years. The goal is to confirm the…

This study tests a new drug called IMVT-1402 in 120 adults with active, difficult-to-treat rheumatoid arthritis (RA) who have a specific antibody (ACPA-positive). The goal is to see if the drug can help control the disease and reduce joint pain and swelling. Participants will rec…

This study tests a new treatment called CAR-T cell therapy against a standard drug, rituximab, in people with active rheumatoid arthritis that hasn't improved with other treatments. The goal is to see if CAR-T cells are safe and can reduce harmful antibodies linked to the disease…

This study looked at how well a metal plate (A.L.P.S. Proximal Humerus Plating System) works for fixing broken upper arm bones. It included 135 adults who needed surgery for a fresh fracture. The main goal was to see how many people needed another surgery within a year due to pro…

This study is checking how safe and well a new shoulder implant, the Sidus Stem-Free Shoulder, works for people with severe shoulder arthritis. About 152 people who need a shoulder replacement are taking part. The study looks at pain, movement, and quality of life after surgery.

This study tests an experimental drug called LY3541860 in 35 adults with moderate-to-severe rheumatoid arthritis that did not improve enough with other medications. The goal is to see if the drug can reduce joint swelling, pain, and inflammation. Participants receive the drug for…

This study watches for side effects in 881 people with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis who receive Remsima under the skin. It aims to see how safe the injection is over time. Participants must have active disease that didn't respond…

This study is testing a new knee implant called Persona Ti-Nidium in 240 adults who need a total knee replacement due to arthritis or other knee problems. The goal is to see if the implant is safe and helps people move better and feel less pain. Participants will have surgery and…

This study tests a non-invasive device that uses low-frequency electromagnetic waves to help immune cells communicate better. The goal is to reduce flare-ups in people with lupus, rheumatoid arthritis, or multiple sclerosis. 120 adults will receive either real or placebo sessions…

This study tracks 200 people who received a cementless knee implant (GMK Sphere) to see how well it works over time. Participants have severe knee damage from arthritis or other conditions. The goal is to measure implant survival and knee function, not to cure the underlying dise…

This study looks at whether the Shingrix vaccine is safe and effective for people with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who have a higher risk of shingles. About 2,000 participants will receive the vaccine or no vaccine, and researchers will moni…

This study looks at whether a 12-week program of high-intensity interval exercise can help people with rheumatoid arthritis improve their heart and blood vessel function, reduce inflammation, and feel better overall. About 87 adults with stable, low-to-moderate disease activity w…

This study looks at whether doing foot core exercises at home, guided by video calls or online sessions, can reduce foot pain and improve walking and balance in people with rheumatoid arthritis. The study involves 18 adults aged 18-65 with rheumatoid arthritis. Participants will …

This study tests a 6-month patient education program for 88 adults with rheumatoid arthritis. The program includes group sessions and individual activities on disease management, self-care, and stress. Researchers want to see if it improves quality of life, knowledge, and treatme…

This study tests an online program designed to help people with inflammatory arthritis stay employed. About 528 adults with conditions like rheumatoid arthritis or lupus will either use the program or receive standard care and printed materials. The program includes eLearning and…

This study aimed to test the safety of an experimental drug called F8IL10, given as a joint injection every 4 weeks for 8 weeks, in people with rheumatoid arthritis who still have flare-ups despite standard treatments. The study was withdrawn before any participants were enrolled…

This study looks at whether giving people with inflammatory arthritis extra help—like a list of community resources, a community specialist, or a nurse navigator—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed a…

This study follows 2000 adults with rheumatoid arthritis in Japan to see how well different medications work and what side effects occur in everyday medical practice. Participants continue their normal prescribed treatments while researchers track joint pain, swelling, and seriou…

This study looks at how getting older changes the way rheumatoid arthritis (RA) affects people. Researchers will compare 420 RA patients and 420 healthy adults aged 55-85 to see how joint pain, thinking skills, and physical abilities change with age. The goal is to create age-spe…

This study planned to follow women with rare autoimmune diseases (like lupus or arthritis) through pregnancy to learn about complications and improve care. It was withdrawn before any participants enrolled, so no results are available. The goal was to gather information to help d…

This study follows 25 adults with rheumatoid arthritis for one year to see how their blood samples relate to changes in disease activity. Researchers want to find early warning signs of flare-ups. Participants give blood at several visits while doctors track their joint swelling …

This study was designed to learn how body weight changes the way etanercept works in obese adults and children with arthritis. Researchers planned to measure drug levels and disease activity scores. The study was withdrawn before enrolling any participants, so no results are avai…

This study follows about 1,600 adults with rheumatoid arthritis over time to learn why some treatments work better than others and why some people have side effects. Researchers collect health data and samples to find biological markers that could predict how the disease will pro…

This study is watching 230 adults who get a G7 hip replacement system to see how long the implant lasts and how well it works. It includes people with hip arthritis or other joint damage. The goal is to gather real-world data on implant survival and patient recovery, not to test …

This study aimed to see if holistic education could help people manage stress and related conditions like anxiety, fatigue, and PTSD. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who agreed to a smoke-free, drug-free, and alcohol-free lifestyle. The …

This study uses advanced heart scans (coronary CT angiography) to understand why people with rheumatoid arthritis face higher risks of heart disease, lung problems, and depression. Researchers will follow 4,000 participants aged 50-75 for up to 10 years, collecting blood samples,…

This study reviews medical records from over 500,000 Medicare patients who had major orthopedic surgeries like hip or knee replacements. The goal is to find patterns in complications and see if care has improved over time. No new treatments are tested; instead, researchers hope t…

This study looks at how well shoulder implants work over time in 160 people with various shoulder problems like arthritis or fractures. Researchers collect data from a database to see how long the implants last and how safe they are. The goal is to help doctors and engineers make…

This study looks at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug Leflunomide (Arava), used for rheumatoid and psoriatic arthritis. Researchers will survey about 3,500 doctors and pharmacists to see if they received and read…

This study is creating a large collection of blood samples from 3,000 people with rheumatoid arthritis. Researchers will use these samples to look for biomarkers that could help predict disease activity or side effects. Participants must already be in a registry and starting a ne…

This study collects information on how well a shoulder replacement implant works over time in about 194 people. It includes patients with arthritis, bone death, or previous failed treatments. The goal is to track implant survival and shoulder function for up to 10 years after sur…

This study aimed to see if taking a small sample of joint tissue (synovial biopsy) could help doctors choose the right biologic drug for people with rheumatoid arthritis who haven't gotten better with standard medicines. The goal was to match each patient to the most effective tr…

This study tests a new PET imaging method to see where rheumatoid arthritis (RA) is active in the body. About 10 adults with RA will receive a special tracer that highlights inflamed joints. The goal is to improve how doctors detect and monitor RA, not to treat it.

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This research registry follows over 91,000 adults with rheumatoid arthritis to see how well approved treatments work and how safe they are. Participants are cared for by rheumatologists across North America. The study does not test new drugs but collects real-world data to improv…