RHEUMATOID ARTHRITIS

This early-phase study tests a treatment called GC012F for people with difficult-to-treat rheumatoid arthritis. The goal is to see if it is safe and how long the modified immune cells stay in the body. Only 9 adults aged 18 to 75 will take part. This is not a cure, but aims to co…

This study looks at how baricitinib, a drug for rheumatoid arthritis, affects blood clotting and cholesterol levels. Researchers will compare baricitinib to standard treatments in 100 adults with active RA. The goal is to see if baricitinib can reduce heart disease risks often li…

This study tests a new daily pill called ivarmacitinib for people with rheumatoid arthritis who did not get better with standard treatments. The drug works by blocking inflammation signals in the body. Researchers will check if it reduces joint pain and swelling after 12 weeks, a…

This study tests whether adding a new drug, natrunix, to the standard treatment methotrexate helps control moderate to severe rheumatoid arthritis better than methotrexate alone. About 108 adults who have not responded well enough to methotrexate will receive weekly injections fo…

This study follows 150 adults with moderate-to-severe rheumatoid arthritis who have received the SetPoint System, an implanted device that uses nerve signals to reduce inflammation. Researchers will track how well the device works, its safety, and ease of use in everyday medical …

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on the person's weight. The goal is to see if the simpler fixed dose works just…

This early-stage study tests a single infusion of stem cells from donated umbilical cord tissue in 16 adults with moderate to severe rheumatoid arthritis that hasn't responded well to standard treatments. The main goal is to check safety and side effects over 52 weeks. Researcher…

This study tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are also overweight or obese. Twenty adults with active arthritis despite standard treatment will receive either dis…

This study tests an experimental injection called GenSci120 in 450 adults with moderate-to-severe rheumatoid arthritis who did not get enough relief from at least one standard medication. The goal is to see if the drug reduces joint swelling and pain better than a placebo or an e…

This early-stage study aims to check the safety and how the body processes a new experimental drug called BMS-986454 in people with rheumatoid arthritis. It will involve 46 participants who have arthritis that didn't fully respond to standard methotrexate treatment. Researchers w…

This study looks at whether adding venlafaxine, a drug usually used for depression, can improve symptoms in people with rheumatoid arthritis who still have moderate to high disease activity despite standard treatments. About 70 adults will receive either venlafaxine or a placebo …

This study looks at whether combining resistance exercises with an anti-inflammatory diet can reduce pain, improve daily function, and boost quality of life in adults with rheumatoid arthritis. One hundred participants will follow a structured exercise program and a special diet …

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find biological patterns that distinguish …

This study looks at 72 adults with rheumatoid arthritis to see if simple blood tests and ultrasound scans can better track how well treatments are working. Researchers will compare patients taking JAK inhibitors with those on standard therapies. The goal is to find easier, more a…