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Exercise as medicine? new study tests High-Intensity workouts for rheumatoid arthritis

NCT ID NCT05768165

Symptom relief Sponsor: Vastra Gotaland Region Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a 12-week program of high-intensity interval exercise can improve heart function, reduce inflammation, and boost quality of life in people with rheumatoid arthritis. 87 adults with stable, low-to-moderate disease activity will take part. The program includes supervised aerobic and resistance training twice a week, plus one optional session on their own.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-intensity interval exercise
What this could lead to
If it works, this could point toward a safe, drug-free way to improve heart health and reduce inflammation in people with rheumatoid arthritis.
What could go wrong
This is a small, early-stage study with only 87 participants, so results may not apply to everyone. Exercise may be hard to sustain long-term, and benefits might be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

87 people

The number who actually took part.

Started

Aug 2021

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Rheumatoid arthritis disease according to the American College of Rheumatology (ACR)/ The European Alliance of Associations for Rheumatology (EULAR) 1987/2010 criteria * Disease duration \>1 year * Age (range 20-60 years) * Stable medication on anti- rheumatic drugs for \>3 months * Low-to-moderate disease activity (\<5.1) according to the Disease activity score 28 (DAS28) Exclusion Criteria: * Cerebrovascular diseases * Diabetes * Severe hypertension * Chronic obstructive pulmonary disease or other severe pulmonary diseases * Other severe diseases that may be associated with adverse events or restrict participation in high-intensity exercise * Arthroplasty of large joints * Inability to manage Cardiopulmonary Exercise Testing (CPET) * Pregnancy * Already participating in regular aerobic or strength exercise at a high intensity level (\>1 hours/ week) during the last 6 months * Inability to speak or read Swedish.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rheumatoid arthritis

Contacts and locations

Locations

  • Sahlgrenska university hospital

    Gothenburg, 413 45, Sweden

  • Uddevalla Hospital

    Uddevalla, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.