COPD

This study tested whether training local health workers in 80 remote Indian villages could lower death rates among adults aged 16-60. Over 72,000 people took part. The workers provided education, treatment, and referrals for conditions like high blood pressure, diarrhea, pneumoni…

This study tested whether mepolizumab, a drug already used for asthma, can help people with COPD who have frequent flare-ups and high levels of certain immune cells (eosinophils). Thirty-one participants took the drug for a year and had special MRI scans to measure lung inflammat…

This study compared two different triple-combination inhalers (BGF and FUV) in 22 adults with stable COPD. The goal was to see if one works better for small airway disease. Participants used each inhaler for a period and had their lung function tested. The study is complete and p…

This study tested an investigational drug called vapendavir in 52 adults with COPD (a chronic lung disease). The goal was to see if vapendavir could reduce lower respiratory symptoms like cough, wheezing, and shortness of breath after they were exposed to a common cold virus (rhi…

This early-stage study tested a drug called EP395 in 49 healthy adults to see if it could reduce inflammation in the lungs. Participants inhaled a substance that causes temporary airway inflammation, and researchers measured whether EP395 lowered that response compared to a place…

This study tested Trimbow, a triple-combination inhaler, in over 1,300 people with moderate to severe COPD whose symptoms were not well-controlled with standard two-drug inhalers. Researchers measured changes in symptom scores and lung function over six months of routine care. Th…

This study tested a new inhaler that combines three medicines (CHF 5993) against a two-medicine inhaler (CHF 1535) in over 3,400 adults with COPD. The goal was to see if the triple therapy improves lung function and reduces serious breathing attacks over one year. Participants us…

This study tested whether a drug called mepolizumab can help people with a type of COPD (lung disease) who have high levels of certain white blood cells (eosinophils). The drug was given after a serious flare-up that required a hospital stay. The goal was to see if it could preve…

This study tested an Ectoin inhalation solution in 36 women aged 75–80 with COPD and lung inflammation. The goal was to see if it could reduce inflammatory markers and slow the decline in lung function over time. Ectoin is a natural substance that may help protect the lungs from …

This study tested a new approach for people with severe COPD: using a simple blood test (eosinophil count) to decide when it's safe to reduce inhaled steroids and when to add an antibiotic (azithromycin). The goal was to lower the risk of flare-ups and hospital stays while avoidi…

This study looked at whether a once-daily inhaler (TRELEGY ELLIPTA) can reduce the need for extra breathing treatments in adults hospitalized for COPD flare-ups. About 80 participants took the inhaler plus short-term steroids and were followed for 30 days after leaving the hospit…

This study tested whether a supplement called Bioarginine, taken twice daily for 6 weeks, could improve breathing and daily life in people with COPD. 153 adults with moderate COPD and a history of smoking participated. The goal was to see if Bioarginine, when added to their regul…

This study followed 661 Italian adults with moderate to severe COPD who were prescribed the Trimbow inhaler. Researchers wanted to see if the treatment improved patients' health status and how well they stuck to their medication routine over 12 months. The study did not test a ne…

This study looked at whether adding casein protein and leucine (a building block of protein) to meals could help people with COPD and healthy older adults build muscle. Weight loss and muscle loss are common in COPD and can make the disease worse. Researchers tested different com…

This study tested two gentle hand techniques (rib lifting and chest pumping) combined with diaphragm release in 66 people with moderate-to-severe COPD. The goal was to see if these methods improve diaphragm movement and reduce shortness of breath. Participants were aged 60-75 and…

This study tested a new inhaled drug called JKN2304 in 42 people with moderate to severe COPD. The goal was to see if it is safe and helps improve lung function over 14 days. Participants received either JKN2304, a placebo, or an active comparator drug. The trial has been complet…

This study looked at which combination of inhalers works best to open the lungs during a COPD lung attack. 37 people with COPD who were having a lung attack took part. They used a gentle breathing test called oscillometry to measure lung function after different inhaler combinati…

This study tested a telephone-based nurse coaching program for older adults (age 60+) with moderate to very severe COPD and their care partners. The program, called EPIC, provided six sessions for patients and four for care partners, focusing on palliative care and quality of lif…

This study tested whether using a hand fan for 10 minutes each day for six weeks could help people with COPD feel less short of breath, and also improve how they think about their illness, and reduce anxiety and depression. 59 patients took part, with half using the fan and half …

This study looked at whether sleeping with the head and back raised (using an adjustable bed) can improve sleep quality for people with advanced COPD. About 24 participants tried both a flat and raised sleeping position for 4 weeks each. The goal was to see if the raised position…

This study tested two breathing methods—Wim Hof and box breathing—in 60 adults with mild COPD. The goal was to see if these techniques could help reduce anxiety, shortness of breath, and improve lung function. Participants practiced one of the two techniques, and researchers meas…

This study looked at whether using a HEPA air purifier at home can improve lung health in adults with a type of COPD called eosinophilic COPD. 178 people took part; half received real purifiers and half received fake ones. The main goal was to see if the purifiers helped increase…

This pilot study tested a 15-minute, twice-daily controlled breathing program called REST in 20 adults with COPD who had high stress levels. Participants attended two in-person sessions and practiced at home. The goal was to see if the program was easy to follow and acceptable, a…

This study tested whether an internet-based walking program with a pedometer could help veterans with COPD who cannot attend hospital rehab become more active. 146 veterans took part. The program aimed to increase daily steps and improve confidence in exercise. Results showed it …

This study tested whether a home-based pulmonary rehabilitation program can improve symptoms and quality of life for people with COPD. 128 participants either received the 8-week home program (exercise sessions and phone support) or standard clinic care. The goal was to see if th…

This study tested whether a home-based exercise program using video games (exergaming) with remote supervision by a physiotherapist could improve physical fitness in people with COPD. 92 participants were split into two groups: one did exergaming three times a week for 12 weeks, …

This study looked at whether adding balance exercises to standard lung rehab can reduce fall risk in people over 80 with COPD. 21 participants were split into two groups: one did the usual rehab, the other added balance training. The goal was to see if balance improved and falls …

This study looked at whether playing the harmonica for 12 weeks can strengthen breathing muscles and reduce shortness of breath in people with COPD. Fifteen patients who had completed pulmonary rehab at least six months earlier took part. They attended weekly one-hour group sessi…

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce shortness of breath and improve lung function in people hospitalized for a COPD flare-up. Thirty participants received either real tDCS or a sham (fake) version alongside standard physical…

This study looked at two types of exercise training—core stabilization and breathing muscle training—in 36 people with COPD. The goal was to see which approach better improves diaphragm function, breathing strength, exercise ability, and quality of life. Participants were stable …

This study tested whether using virtual reality (VR) glasses for 30 minutes each evening could help people with COPD in the intensive care unit sleep better and feel less anxious. Fifty patients took part, with half using VR and half receiving standard care. The results showed th…

This study tested two different leg exercises in 102 people with severe COPD: one group used a bike, the other used mild electrical pulses to stimulate their thigh muscles. The goal was to see which method better improved leg strength and daily function during a 3-4 week hospital…

This study tested a breathing exercise program for people with stable, severe COPD who are prone to flare-ups. The program combines inspiratory muscle training with positive expiratory pressure therapy. Researchers measured changes in lung function, muscle strength, and breathles…

This study tested whether teaching self-hypnosis to people with severe COPD can reduce anxiety and shortness of breath during a pulmonary rehabilitation program. 133 adults took part, using hypnosis alongside their usual care. The goal was to see if this mind-body technique could…

This small pilot study tested whether a 12-week tai chi program is feasible and helpful for people with chronic obstructive pulmonary disease (COPD). Ten participants were assigned to either tai chi or usual care. The study focused on whether tai chi could improve quality of life…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can help doctors screen, diagnose, and manage patients with respiratory diseases like COPD, asthma, and COVID-19. Over 600 participants used the app to track their coughs, and researchers compared the app's…

This study looked at whether a special questionnaire called VQ11 can measure improvements in quality of life for people with COPD who start a new long-acting inhaler. 57 adults with stable COPD (no flare-ups in the past 6 weeks) filled out the questionnaire before and 3 months af…

This study looked at how a mix of home and in-clinic circuit exercises affects muscle loss and fatigue in 72 adults aged 30-85 with COPD, sleep apnea, or lingering COVID-19 symptoms. Participants completed 18 exercise sessions, 12 in person. The goal was to understand the body's …

This study looked at 200 older adults with COPD and a condition called sarcopenic obesity (muscle loss with excess fat). Researchers used a special body scan to measure body composition and see if it could help predict breathing problems, hospital stays, and quality of life. The …

This study tested a simple breathing test called impulse oscillometry (IOS) in 38 people with COPD during a flare-up and again 6-12 weeks later when they felt better. The test measured how well small airways were working and showed clear improvements during recovery. Researchers …

This study looked at whether short bursts of exercise (interval training) help keep oxygen levels higher in people with COPD who experience drops in oxygen during exercise. Twelve patients completed both an interval and a continuous exercise session while their oxygen was monitor…

This study looked at whether a family of proteins called GPCRs, found on the surface of cells, could be used as biomarkers to help diagnose or track chronic lung diseases like asthma and COPD. Researchers analyzed blood samples from 205 people (healthy volunteers and patients wit…

This study looked at whether taking two blood thinners (aspirin and clopidogrel) for two weeks can improve blood flow in the lungs of current and former smokers, both with and without COPD. Fifteen people participated in a crossover design where each person received both the acti…

This study looked at whether doing virtual reality exercises with other people (multi-player) is more motivating than doing them alone. It included 86 participants: healthy teens, children and adults with movement problems, and older adults with lung conditions. The goal was to s…

This study looked at how missing a full night of sleep affects shortness of breath and exercise ability in people with COPD. Twenty adults with COPD completed two tests: one after a normal night's sleep and one after staying awake all night. Researchers measured how hard it felt …

This study looked at medical records of 59 adults with COPD to see if a standard breathing and exercise program (pulmonary rehabilitation) works as well for those who also have pulmonary hypertension (high blood pressure in the lungs). Researchers compared how far people could wa…

This study looked at how a new drug called EP395 interacts with other common medicines in 37 healthy adults. The goal was to check if EP395 changes how the body processes certain drugs, which is important for future use in people with COPD. Participants took EP395 along with othe…

This study tested whether a mobile app that gives visual feedback and motivational reminders can help older adults (60+) with conditions like COPD, heart failure, or Parkinson's spend more time out of bed while in the hospital and for three months after going home. Researchers tr…

This study looked at 150 adults with COPD to see if a decline in exercise performance during pulmonary rehabilitation could predict when a flare-up (exacerbation) might happen. Researchers tracked changes in physical capacity and compared them to hospital admissions and symptom s…

This study looked at 100 people with COPD in Dutch general practices to see if their treatment could be improved. Doctors used an online tool called the COPD Optimiser to check if patients were getting the best care based on international guidelines. The goal was to find common a…

This study used a special MRI technique with a harmless helium gas to measure how fast air moves through the windpipe. Researchers scanned 24 volunteers, including healthy people and those with COPD or constrictive bronchitis. The goal was to collect real data to improve computer…

This study tested a new way to detect early lung changes in people with COPD or ILD by analyzing carbon dioxide (CO2) in their breath in real time. The goal was to find damage before standard lung function tests show any problems. Researchers compared results from 40 participants…

This study looked at how the nasal immune system responds to a live, weakened flu vaccine in 24 people with COPD. Researchers compared those who had frequent flare-ups (two or more in the past year) to those who did not. The goal was to understand differences in immune signals an…

This early-stage study tested a new medicine called 9MW1911 in 48 healthy adults to see if it is safe and how the body processes it. The goal was to find the right dose and check for side effects, not to treat any disease. Results will help guide future studies in people with ast…

This study tested whether a large language model (like GPT-4) could help doctors follow official treatment guidelines for COPD patients at hospital discharge. 78 patients were randomly assigned to either receive an AI-generated treatment recommendation or standard care. The goal …

This study measured breathing patterns in 163 people with asthma or COPD to help computers predict how aerosol drugs deposit in the lungs. Researchers aimed to find links between breathing, disease severity, and drug dose. The goal is to make inhaler therapy more personalized and…

This study looked at whether doing thinking tasks while exercising (dual-tasking) improves movement and brain function in people with COPD. 42 participants were split into two groups: one did standard pulmonary rehab, the other added cognitive tasks to walking and cycling. Resear…

This study involved 176 people with COPD who completed a 4-week pulmonary rehabilitation program. Researchers wanted to see if performing two 6-minute walk tests at the end of the program gives a more accurate measure of patients' exercise capacity than just one test. The goal is…

This study tested whether live vaccines can 'train' the immune system to reduce harmful inflammation in people with COPD. Sixty adults with COPD received a live vaccine, and researchers measured changes in immune cell activity over four months. The goal was to see if this approac…