COPD

This study looks at whether using a home breathing device (OPEP) and doing aerobic exercise can help people with moderate to severe COPD have fewer serious flare-ups and hospital visits. About 312 adults aged 40-80 will be split into four groups: standard care, OPEP alone, exerci…

This study tests whether atorvastatin, a widely used cholesterol medication, can reduce lung inflammation and prevent flare-ups in smokers with COPD. About 460 participants will receive either atorvastatin or a placebo for several months. The goal is to see if the drug can help c…

This study looks at whether a special care plan, called a transition bundle, can help people with COPD avoid serious health declines after a flare-up. About 1,368 patients from 36 hospitals will take part. Hospitals are randomly assigned to either use the new care plan or continu…

This study looks at whether ongoing support from a nurse can help people who smoke and are at risk for COPD quit smoking. About 233 smokers aged 35-65 will be followed over time. The goal is to see if regular check-ins reduce the number of cigarettes smoked per day.

This study compares two breathing treatments—high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV)—for people with COPD who have just had a breathing tube removed. The goal is to see which method better prevents the need for another breathing tube within 72 hours. Abou…

This study is developing and testing a program that combines physical activity coaching with mental health support for veterans who have COPD, depression, or anxiety. The goal is to see if the program is practical and helpful for improving daily function and mood. About 45 vetera…

This study tests whether taking a probiotic supplement can reduce shortness of breath and improve daily symptoms in adults with COPD. About 60 participants will receive either a probiotic or a placebo for 16 weeks. Researchers will measure changes in breathing, lung function, and…

This study will follow 10,000 Italian adults with COPD to learn more about the disease's impact, including how often flare-ups happen, what other health problems occur, and how many patients die each year. Researchers will collect information from medical records and routine chec…

This study is testing a small, wearable device called the RESP Biosensor that listens to lung sounds and tracks breathing movements. It is designed for people with COPD who have recently been hospitalized or seen a doctor for a flare-up. The goal is to see if the device can be us…

This study works to create a simple questionnaire that helps doctors find small airway problems in people with COPD. Researchers will test the questionnaire on 108 adults and compare it with standard breathing tests. The goal is to make diagnosis easier and more accurate in every…

This study looks at how often and when doctors talk with seriously ill patients about their care wishes. It includes up to 5,000 adults with cancer, heart failure, COPD, or dementia. The goal is to find ways to make these important conversations happen earlier and more often.

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to better understand how the disease progresses. Researchers measure lung function, mucus, and CT scans, and also look at how things like air pollution and home environment affect health.…

This study looks at how a structured exercise and education program (pulmonary rehabilitation) affects inflammation and oxidative stress in people with stable COPD. Researchers will measure certain blood markers before and after the program in 27 adults aged 40-80. The goal is to…

This study aimed to use a special MRI technique with hyperpolarized xenon gas to see how lung function changes in people with COPD after a procedure called targeted lung denervation. The goal was to better understand the treatment's effects on breathing. However, the study was wi…

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19 (including Long COVID). Researchers will track up to 160 participants over several years to understand how these diseases change the lungs over time. The goal is to…

This study looks at whether offering simple breathing tests to smokers who have already had a lung CT scan can help find COPD earlier. Many people lose a lot of lung function before they are diagnosed, and this damage cannot be reversed. About 568 participants will be invited for…

This study looks at 1,600 adults in Hong Kong who have been diagnosed with asthma or COPD to find out how many actually have both conditions (called Asthma-COPD Overlap). Researchers will track their health for 3 years to see how they do and whether their treatments match current…

This study tests a new, tiny camera (micro OCT) that can take detailed pictures of the airways in the lungs and nose. Researchers want to see if it works well in adults with cystic fibrosis and healthy volunteers. The goal is to better understand early lung damage, which could le…