COPD

This study tests an experimental drug called XKH001 in 75 people with moderate to severe COPD. The goal is to see if the injection can improve lung function and is safe. The trial has two stages, lasting up to 52 weeks of treatment. Participants will receive either XKH001 or a pl…

This study tests if the inhaled drug iloprost can safely lower high blood pressure in the lungs (pulmonary hypertension) and improve exercise ability in adults with severe COPD. Fifteen participants will take iloprost 6 to 9 times daily for 12 weeks, with no placebo group. Resear…

This study looks at whether using a non-invasive ventilator (BiPAP) at home can help people with severe COPD who have high carbon dioxide levels. Forty adults will use the machine nightly for a period, and researchers will track changes in their blood gases, how often they use th…

This early-stage study tests a new inhaled medicine called HRS-9821 for COPD. It will first check safety in 48 healthy volunteers and then in people with COPD. The goal is to see if the drug is safe and how it moves through the body.

This study tests if a pharmacist-led mobile game can improve health in adults aged 50 and older with COPD. Participants will use the game at home for 2 weeks and receive pharmacist guidance. The goal is to see if this approach improves health status, inhaler technique, and medica…

This study tests a new treatment called Targeted Lung Denervation (TLD) for people with moderate to severe COPD. The procedure uses a catheter to target nerves in the lungs, aiming to reduce symptoms and improve quality of life. About 300 participants will be randomly assigned to…

This study tests whether a respiratory syncytial virus (RSV) vaccine can reduce moderate-to-severe COPD flare-ups in people who have frequent attacks. Researchers will enroll 320 COPD patients who have had at least two flare-ups in the past year despite using standard inhalers. H…

This study tests if a special breathing device can help Veterans with COPD improve their breathing and exercise ability faster during pulmonary rehab and keep those benefits longer. About 120 Veterans will be randomly assigned to use either the real device or a sham device that d…

This study tests a 3-month rehabilitation program for people with COPD, a chronic lung disease. The program includes exercises done both in the hospital and at home. Researchers want to see if it helps patients walk farther and feel better. About 70 adults over 40 with moderate t…

This study looks at whether attending pulmonary rehabilitation once a week works as well as going three times a week for people with COPD. About 158 participants will follow an 8-week program with home exercises. The goal is to see if the less frequent option improves breathing a…

This study compares two breathing devices—the Breather and the incentive spirometer—to see which better reduces breathlessness, improves lung function, and boosts quality of life in people with mild to moderate COPD. Eighty adults aged 45 to 65 will use one of the devices and be …

This study tests a new device called MoblO2 that automatically adjusts oxygen levels for people with COPD or interstitial lung disease who need supplemental oxygen. Instead of constantly checking and adjusting their oxygen flow, users set a maximum level and the device keeps thei…

This study looks at whether using a whiteboard at the bedside can help people with COPD feel less anxious and depressed, and more satisfied with their nursing care. About 128 hospitalized COPD patients will be randomly assigned to either have a whiteboard or not. Researchers will…

This study looks at whether a nurse-led breathing exercise called Pursed Lip Breathing can help people with COPD feel less anxious and have better vital signs (like heart rate and oxygen levels) right after a bronchoscopy. About 64 adults with COPD who are having a planned bronch…

This study tests a 20-week program of diet and exercise in 70 adults who have both COPD and obesity. The goal is to see if losing weight can improve their ability to walk, breathe, and feel better day-to-day. Researchers will measure lung function, body composition, and signs of …

This study looks at whether people with COPD get more benefit from their bronchodilator medication when they inhale it at a higher lung volume (functional residual capacity) instead of the usual lower volume (residual volume). The idea is that the drug may spread more evenly in t…

This study tests if a gentle, non-invasive brain stimulation (NIBS) can improve memory and attention in people with COPD who have thinking problems. Twenty-four adults with stable COPD and mild cognitive issues will receive either real or fake stimulation for 20 minutes a day, 5 …

This study will measure certain proteins and cells in the blood of 75 adults hospitalized with a COPD flare-up. The goal is to see if these markers can predict how serious the episode is. Researchers hope this could lead to better, faster treatment decisions for patients.

This study aims to collect health information and blood samples from 15,000 adults aged 40-70 over time. Researchers will use artificial intelligence to analyze molecular patterns in the blood to find early signs of diseases like heart disease, diabetes, cancer, and lung disease.…

This study looks at 120 adults with asthma or COPD to see how different lung function tests relate to how much their breathing improves after using a bronchodilator (rescue inhaler). The goal is to find out which test best matches patients' own reports of feeling less short of br…

This study tests a new computer system that helps pharmacists provide better care for people with COPD. The tool guides them through symptom checks, medication reviews, and creating action plans. Researchers will see if using the system in 6 pharmacies improves care compared to t…

This study looks at whether giving people with heart disease, asthma, or COPD real-time air quality information on their phone helps them avoid pollution while exercising outdoors. About 80 adults will use a special app that tracks their activity and local pollution levels. The g…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will analyze a single blood sample from 100 adults to see how certain immune cells respond to inflammation and infection. Participants won't re…

This study looks at lung tissue from 150 people with and without COPD to understand the disease at a very detailed level. Researchers will use advanced single-cell sequencing to see what goes wrong in the cells. The goal is to learn more about how COPD develops, not to test a new…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and whether their test results improve. The goal is to understand what helps or hinders success in these …

This study explores whether a special ultrasound technique called shear wave elastography can measure how hard someone is working to breathe. Currently, doctors use a thin tube placed in the esophagus, which is uncomfortable and invasive. The study will include 20 adults—some wit…

This study looks for hidden heart and kidney problems in 150 adults hospitalized for a COPD flare-up. Researchers will screen patients and track their health to understand risks and improve future care. The goal is to learn, not to test a new treatment.

This study will follow 3,000 people with COPD who have had at least two serious flare-ups in the past year. Researchers will collect data from medical records and surveys to understand how the disease progresses, what treatments people use, and how flare-ups affect quality of lif…

This study looks at how the drug erdosteine affects inflammation and oxidative stress in people with COPD. Researchers will compare 15 patients taking erdosteine plus standard care with 15 patients on standard care alone over 4 weeks. The goal is to understand the biological mech…