Anemia

This trial tests whether screening for anemia at the time a patient consents to hip or knee replacement surgery, which is usually 4 to 6 months before the operation, leads to better outcomes than the standard approach of testing only 2 to 4 weeks before surgery. About 800 adults …

This trial tests whether an oral drug called roxadustat can treat anemia in people with diabetic nephropathy and chronic kidney disease as effectively as the standard erythropoietin injections. About 64 adults aged 18 to 75 will receive either roxadustat pills three times a week …

This trial tests whether a single intravenous dose of iron, given 3-4 weeks before elective abdominal or pelvic surgery, can raise hemoglobin levels in patients with iron-deficiency anemia. The goal is to see if this simple pre-op step reduces the need for blood transfusions, low…

This trial is testing whether a new version of darbepoetin alfa works as well as the standard treatment (Aranesp) for anemia in people with chronic kidney disease who are on dialysis. Participants will receive either the new drug or Aranesp by injection every other week for 24 we…

This phase 2 trial tests whether personalized dosing of epoetin alfa—a lab-made hormone that boosts red blood cell production—can reduce or eliminate the need for blood transfusions in very low birth weight premature infants with neonatal anemia. Researchers will study how the dr…

This study tests whether using smaller tubes for routine blood draws can reduce the number of red blood cell transfusions needed by anemic patients in intensive care. About 688 adults with low hemoglobin will be randomly assigned to have blood drawn with either small or standard-…

This study tests whether giving blood transfusions more liberally (when hemoglobin drops to 9 g/dL) versus more restrictively (when it drops to 7.5 g/dL) reduces death and serious complications like heart attack, stroke, or kidney injury in patients aged 70 and older undergoing n…

This study looks at whether heart failure patients with iron deficiency anemia respond better to oral iron supplements when they are also taking a type of heart medication called SGLT2 inhibitors. Participants take oral iron for three to four months, then pause treatment while do…

This study tests whether a low daily dose of the antibiotic linezolid, added to a personalized combination of other drugs, is safe and tolerable for people with multidrug-resistant tuberculosis (MDR-TB). Participants take either linezolid or a placebo for 16 weeks, alongside thei…

This study tests whether a single intravenous (IV) dose of iron works better than daily oral iron pills to treat moderate anemia in new mothers. About 4,800 women who have moderate anemia 6 to 48 hours after delivery will receive either a one-time IV iron infusion plus folic acid…

This study tested whether an iron injection works better than iron pills for treating anemia in 200 new mothers within 10 days of giving birth. Participants had mild to moderate anemia and were randomly assigned to receive either a single injection of ferric carboxymaltose or ora…

This study tested whether measuring oxygen levels in the blood (ScvO2) can help doctors decide when to give blood transfusions to anemic patients after heart surgery. 100 patients were randomly assigned to receive transfusions based on standard guidelines or only if their ScvO2 w…

This study tested whether giving iron supplements daily or weekly works better to prevent anemia in healthy Thai infants aged 6 to 12 months. A total of 287 babies were randomly assigned to receive iron daily or weekly for 3 months, then all switched to weekly for another 3 month…

This study tested a drug called luspatercept in 30 adults from China and Japan who have a bone marrow disorder (MDS) and need regular red blood cell transfusions. The goal was to see if the drug could help them go without transfusions for at least 8 weeks. The drug works by helpi…

This study tested a new drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) who also have anemia. The goal was to check the drug's safety and how the body processes it. Participants received either the drug or a placebo by injection. The results will …

This study tested whether a peanut-based nutritional supplement could improve health in adults aged 60 and older living in peri-urban Ghana. Over 12 weeks, 81 participants either took the supplement daily or served as a control group. Researchers measured weight, blood pressure, …

This study compared two drugs—roxadustat and darbepoetin alfa—for treating anemia in 35 adults on hemodialysis. The goal was to see if roxadustat improves iron levels and reduces the need for IV iron. Researchers measured changes in iron profile, hemoglobin, and kidney function o…

This study tested an experimental drug called MT-6548 in 42 people in Japan who have anemia due to chronic kidney disease and are on peritoneal dialysis. The goal was to see if the drug can safely raise and maintain healthy red blood cell levels. Participants either switched from…

This study tested a new drug called MT-6548 against a standard treatment (darbepoetin alfa) for anemia in people on dialysis for chronic kidney disease. About 323 participants in Japan received either the new drug or the standard one to see if it worked as well at keeping hemoglo…

This phase 3 trial tested an oral drug called MT-6548 (vadadustat) against a standard injected drug (darbepoetin alfa) for anemia in people with chronic kidney disease who are not on dialysis. The study enrolled 304 participants in Japan to see if the oral drug is at least as goo…

This phase 3 trial tested an oral drug called vadadustat (MT-6548) in 24 Japanese adults on hemodialysis who had anemia due to chronic kidney disease. The goal was to see if the drug could raise and maintain healthy hemoglobin levels safely. Participants took the tablet daily, an…

This study looked at ways to reduce the need for blood transfusions in patients having planned heart surgery with a heart-lung machine. The researchers tested two approaches: improving how doctors decide to give transfusions and treating low iron and anemia before and after surge…

This completed Phase 1 trial tested whether a single IV dose of ferric carboxymaltose works better than daily oral polysaccharide iron complex capsules for treating iron deficiency anemia in pregnant women. 112 women in their second trimester with low hemoglobin levels took part.…

This study tested whether red blood cells from umbilical cord blood are safe and work as well as standard adult donor blood for transfusions in extremely preterm infants (born before 28 weeks). 41 babies received small transfusions, and researchers monitored their vital signs, ox…

This study tested whether giving weekly iron and folic acid supplements along with nutrition education and a small cash payment to mothers could reduce anemia in adolescent girls in flood-affected areas of Pakistan. Over 2,100 girls aged 15-19 took part. The goal was to see if th…

This study looked at how well the drug Roxadustat works for anemia in people with diabetic kidney disease stages 3-4. 124 participants took the drug for 24 weeks, and researchers measured changes in hemoglobin and iron levels. The goal was to see if the drug can safely raise red …

This study tested whether dapagliflozin, a drug typically used for diabetes, can slow kidney decline, improve anemia, and support heart health in 100 adults with chronic kidney disease who do not have diabetes. Participants took either the drug or a placebo daily for 12 months al…

This study tested whether adding erythropoietin (EPO) to the standard drug hydroxyurea can safely raise hemoglobin levels in adults with sickle cell disease. Seventeen participants with chronic anemia took both drugs for 12 weeks. The main goal was to see if at least a 1.0 g/dL i…

This study tested whether giving an intravenous iron infusion to anemic patients before elective heart surgery helps them recover faster. Nearly 1,000 adults with anemia received either IV iron or a placebo 1 to 10 weeks before their surgery. The main goal was to see if the iron …

This Phase 2 study tested an experimental drug called etavopivat in 53 people with thalassemia or sickle cell disease. The goal was to see if the pill could safely reduce the number of red blood cell transfusions needed and raise hemoglobin levels. Participants took 400 mg of eta…

This study looked at whether giving more red blood cell transfusions (liberal strategy) to extremely low birth weight babies (under 1000 grams) helps them survive without brain damage compared to a more restrictive approach. Over 1800 infants from NICUs were followed until 22-26 …

This study tested a new iron supplement called ferric maltol (given as an oral suspension) against the standard ferrous sulfate liquid in children aged 2 to 17 with iron-deficiency anaemia, and also tested ferric maltol alone in infants aged 1 month to 2 years. The goal was to se…

This study tested a drug called daprodustat in children aged 3 months to under 18 years who have anemia due to chronic kidney disease. The goal was to see how the drug moves through the body and if it is safe. Only 4 children took part, and they received the drug for up to 52 wee…

This study looked at whether raising hemoglobin levels with a drug called epoetin (Neorecormon) could improve quality of life and slow kidney function decline in people who had a kidney transplant and now have chronic graft dysfunction. About 128 adults who had a transplant 1 to …

This study looked at whether giving children with iron-deficiency anemia oral iron for 6 to 12 weeks before elective surgery can raise their hemoglobin levels. Researchers enrolled 755 children in South Africa to test this simple, low-cost approach. The goal is to see if treating…

This small study tested whether a daily iron-rich yeast drink with SOD can improve anemia and skin condition in women aged 18-35. Eleven women with mild anemia drank the supplement for four weeks. Researchers measured blood iron levels and skin-related markers before and after to…

This trial tested a program where community health workers used a tablet app to screen pregnant women in rural India for anemia, high blood pressure, and diabetes. Over 3,400 women took part. The goal was to see if this screening and referral system could lower anemia rates and i…

This study looked at how well MIRCERA works for anemia in people with chronic kidney disease stages 3-4 who are not yet on dialysis. Researchers tracked 144 patients over 12 months to see if their hemoglobin levels stayed in a healthy range. The goal was to gather real-world data…

This study tested a monthly injection of Mircera in 75 adults with chronic kidney disease who were not yet on dialysis and had anemia. The goal was to see if the drug could safely raise and maintain hemoglobin levels. Results showed improvement in hemoglobin during the evaluation…

This study tested a special way to treat donated red blood cells to kill germs, called the INTERCEPT Blood System. It involved 581 people having complex heart surgery who needed blood transfusions. The goal was to see if this treated blood is as safe and works as well as regular …

This study tested whether a once-monthly injection of Mircera works as well as the standard epoetin alfa treatment for managing anemia in people on dialysis. About 233 adults with chronic kidney disease-related anemia participated. The goal was to see if Mircera could keep hemogl…

This study compared two intravenous iron treatments—ferric carboxymaltose and iron sucrose—in 40 pregnant women with anemia. The goal was to see which one raised hemoglobin levels more. Both are already used in practice, but local data was lacking. The trial is now complete, and …

This phase 1 trial tested a gene therapy called RP-L301 in 4 people with pyruvate kinase deficiency, a rare inherited blood disorder that causes severe anemia and often requires frequent blood transfusions. The treatment uses the patient's own blood stem cells, which are modified…

Malaria in pregnancy can hide in the placenta and harm both mother and baby, yet it often goes undetected. This study enrolls about 1,200 pregnant women in Africa to see whether malaria rapid diagnostic tests, blood smears, and PCR on maternal blood can accurately detect or predi…

This completed study tested whether artificial intelligence can estimate iron deficiency and anemia risk in African children without a blood draw. Researchers collected blood samples, images, and videos from 126 children under 6 years old to train AI algorithms. The goal is to de…

This study tested whether a non-invasive device that uses light (pulse co-oximetry) can accurately measure hemoglobin levels in children undergoing brain or spine surgery, compared to the standard method of drawing blood from an artery. The goal was to see if this painless, conti…

This trial tests whether giving infants a preventive dose of the antimalarial drug sulfadoxine-pyrimethamine during routine health visits can lower their risk of malaria and anemia. Researchers will follow about 2,100 children in Cameroon, comparing those in areas receiving this …

This trial tests whether giving infants in Côte d'Ivoire a preventive dose of an antimalarial drug at routine health visits can lower their risk of malaria and anemia. Researchers will compare outcomes for infants in areas receiving this intervention against those receiving stand…

This study tests whether giving school children preventive malaria medicine can reduce infections not only in them but also in younger siblings at home. About 1,000 students in rural Malawi will receive either one of two drug combinations or no preventive treatment. Researchers w…

This study tested whether adding daily multivitamins and an extra dose of deworming medication to standard prenatal care could prevent severe anemia in pregnant women in Zanzibar, Tanzania. Over 2,500 pregnant women took part, comparing the enhanced package to the usual WHO-recom…

This study tested whether giving intravenous iron to pregnant women who have low iron stores but not yet anemia can prevent them from becoming anemic and help their babies grow normally. 600 women took part. The goal is to see if a single IV dose works better than usual care.

This trial tests whether heated traditional Chinese medicine plasters can help cancer patients recover from chemotherapy-induced anemia and low blood cell counts. Participants apply the plaster to a specific point on the navel for one hour daily over two weeks. Researchers compar…

This study looked at whether adding nutrition and hygiene support to an existing farming program can reduce malnutrition in pregnant women and their children. About 1,200 pregnant women in Kenya took part, with half getting the extra nutrition help. The goal was to see if childre…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This study asks whether having anemia before major gastrointestinal surgery leads to more complications afterward. Researchers will follow 146 adults in Greece who undergo open or laparoscopic GI surgery, tracking any complications until discharge or day 8 after surgery. They wil…

This study looks back at the medical records of 244 adults in France with hereditary hemorrhagic telangiectasia (HHT), also called Rendu-Osler disease, who were treated with the drug bevacizumab. The goal is to describe how the drug was used and to measure its impact on bleeding,…

This study looked at whether adding folic acid and vitamin B12 to locally made cereals can improve the nutrition, thinking skills, and mood of teenage girls in rural Ethiopia. About 472 girls aged 13-19 took part. The goal was to see if small-scale food fortification can help pre…

This observational study looks at whether a fast drop in hemoglobin during the first 24 hours in the ICU can predict a longer stay (8 days or more) or death in the hospital. Researchers will review medical records of about 128 critically ill adults, comparing their hemoglobin lev…

This study looked at why many older adults (over 70) have anemia even when doctors can't find a reason. Researchers measured how long red blood cells live in younger and older adults by marking them with a vitamin called Biotin. The goal was to understand if faster red blood cell…

This study examined the link between obesity and iron deficiency anemia in 165 nonpregnant Indonesian women aged 19-29. Participants took daily iron-folic acid supplements for 90 days. Researchers compared iron levels between overweight/obese and normal-weight women to see if wei…

This completed study looked at 324 extremely low birth weight preterm infants (≤1250 grams) to see how anemia and red blood cell transfusions affect oxygen levels in their digestive tract. Researchers used a non-invasive device to measure tissue oxygen and collected blood, urine,…

This study examined 236 adults in a surgical intensive care unit who needed a breathing machine for more than 4 days. Researchers wanted to see if the length of time a patient had anemia (low red blood cells) was linked to how long they stayed on the ventilator. The goal was to b…

This completed study surveyed 97 Hungarian anesthesiologists and intensive care doctors about how they decide when to give blood transfusions to critically ill patients. The focus was on whether they use certain physiological signs (like lactate levels or oxygen saturation) recom…

This study looked at whether a special kidney scan (scintigraphy) can find early kidney damage in children and young adults with sickle cell disease better than standard tests. 18 patients were checked during their annual visit. The goal is to catch kidney problems sooner so trea…

This study explored whether low hemoglobin (anemia) is linked to an enlarged heart (cardiomegaly) in children up to 18 years old. Researchers used chest X-rays and echocardiograms to check for heart enlargement in 56 anemic children. The goal was to better understand how anemia a…

This study looked at whether iron supplements improve how well vaccines work in pregnant women with anemia (low iron). Researchers compared their immune responses to tetanus, diphtheria, and COVID-19 vaccines against women without anemia. The goal was to see if correcting iron de…

This study looked at 201 very premature babies born before 31 weeks to see how often they received blood transfusions that went beyond French guidelines. Researchers found that many transfusions were given even when not recommended, possibly due to the babies' fragile health. The…

This study gathered information from 250 children aged 6 months to 6 years to develop artificial intelligence that can estimate iron levels from images and videos. The goal is to create a non-invasive way to screen for iron deficiency, replacing blood tests. Parents and doctors a…

This study looked at over 13,000 adults who had heart surgery to understand how blood transfusions given during the operation might explain why patients with anemia before surgery are more likely to have complications afterward. The goal is to help doctors make better decisions a…

This study looked at whether giving oral iron supplements to iron-deficient women in Kenya before or at the same time as vaccination improves their immune response. 180 women received iron either before or with three vaccines (COVID-19, meningitis, and typhoid), or a placebo. The…

This study looked at why people with sickle cell disease often get hard-to-heal leg ulcers. Researchers measured blood flow, nerve function, and blood markers in 70 patients with and without ulcers. The goal was to better understand what causes these wounds, not to test a new tre…

This study looked at whether intravenous iron treatments (ferric carboxymaltose or ferric derisomaltose) can cause a rare side effect called methemoglobinemia, where blood can't carry oxygen properly. Researchers measured methemoglobin levels in 50 anemic patients before and afte…

This completed study looked at 209 patients with bacterial endocarditis, a serious heart valve infection, to understand how common anemia is and what causes it. Researchers measured blood markers for inflammation and anemia from diagnosis up to 6 months after hospital discharge. …

This study followed 58 babies with sickle cell disease from 3 months to 2 years old to find early clues that might predict a life-threatening spleen complication called acute splenic sequestration. Researchers took blood samples and used special scans to measure spleen size and f…