Rutgers, The State University Of New Jersey

This study is testing whether tirzepatide, a drug used for weight loss, can help people with early-stage hormone receptor-positive, HER2-negative breast cancer lose at least 5% of their body weight during their regular cancer treatment. About 40 participants will take the drug an…

This study tests two counseling approaches—Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement—to help 420 adults on methadone treatment reduce tobacco smoking and other drug use. Participants will receive these therapies and be monitored for days of drug and …

This study tests whether giving a higher-than-standard dose of buprenorphine (32 mg instead of 12 mg) to people with opioid use disorder in the emergency department is safe and helps more of them start addiction treatment within a week. About 140 adults who test positive for fent…

This study tests whether taking statins can prevent heart problems caused by HER2-targeted therapy in women with early-stage breast cancer. About 60 participants will receive statins alongside their cancer treatment to see if it reduces treatment delays or early stops due to hear…

This study looks at whether adjusting the dose of chemotherapy drugs (5-FU or capecitabine) based on a person's DPYD gene test can reduce severe side effects. About 100 adults with certain cancers (like colorectal, breast, or head/neck) will take part. The goal is to see if perso…

This study looks at whether a liver transplant can help people with a certain type of advanced bile duct cancer that hasn't spread. Participants first receive chemotherapy to control the cancer, then undergo a liver transplant. The goal is to see if this approach helps them live …

This study is testing a smartphone app designed to help women in Nepal manage gestational diabetes during pregnancy. The app provides culturally tailored support for self-care, such as tracking blood sugar and lifestyle habits. Researchers will compare outcomes like blood sugar l…

This study tests if a single daily dose of long-acting insulin can control blood sugar in pregnant women with diabetes as well as the standard regimen of long-acting insulin plus mealtime shots. About 176 participants will be randomly assigned to either one daily injection or mul…

This study tests a new way of giving three chemotherapy drugs (TAS-102, oxaliplatin, and irinotecan) along with a targeted therapy (bevacizumab) to people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this combination ca…

This study tests whether adding the drug tislelizumab after standard local treatments (like radiation) can help prevent advanced liver cancer from coming back. About 35 adults with inoperable liver cancer will receive tislelizumab to target any remaining cancer cells. The main go…

This study looks at how different types of exercise affect brain health and Alzheimer's risk in older African Americans. About 280 people aged 60 and older who are not very active will either take cardio-dance classes or strength, flexibility, and balance classes for 6 months. Re…

This study tests whether melatonin, a common sleep aid, can prevent kidney damage caused by the antibiotic vancomycin in hospitalized patients. Researchers will give melatonin or a placebo to 300 adults aged 18 to 75 who need vancomycin for at least three days. The goal is to see…

This study tests whether sulfasalazine, a drug used for arthritis, can prevent preterm birth in women who have had one before. The drug aims to lower a stress hormone linked to early labor. About 50 pregnant women will take either sulfasalazine or a placebo, and researchers will …

This study tests a digital sleep therapy (Sleepio) in teens aged 14-18 who were recently hospitalized for suicide risk and have trouble sleeping. Participants will either get the 6-session app-based treatment plus usual care, or usual care alone. The goal is to see if improving s…

This study tests a special numbing injection (temporo-masseteric nerve block) to see if it lowers pain after wisdom tooth removal. About 20 adults will have the injection during sedation and then report their pain and painkiller use for a week. The goal is to find a better way to…

This study tests whether a special gel called RADA-16 can reduce bleeding and pain after tonsil removal surgery. About 134 adults having their tonsils out will either get the gel or standard care. They will report their symptoms every other day for 15 days after surgery.

This study compares two methods for controlling pain after same-day orthopedic surgeries like ACL repair or rotator cuff surgery. One group gets a continuous pain pump that delivers medication through a small tube, while the other gets a single nerve block injection before surger…

This study tests if a higher dose of radiation (40-50 Gy over 10 sessions) can better relieve pain from cancer that has spread to bones or other areas. About 124 adults with cancer and significant pain will receive this treatment to see if more people get complete pain relief at …

This study looks at two wound dressings used after surgery for severe hidradenitis suppurativa (HS), a painful skin condition. The newer dressing, Pelashield™ PainGuard™, contains silver to fight bacteria and lidocaine to numb pain. It will be compared to the standard Restrata® d…

This study looks at whether a special numbing injection called the Twin Block can reduce jaw muscle pain and the need for opioid painkillers after wisdom tooth removal. About 48 healthy adults who have jaw pain one day after surgery will receive either the Twin Block or a placebo…

This study looks at whether updating radiation plans at set times during treatment can lower side effects for people with non-small cell lung cancer. As tumors shrink from radiation, healthy tissue can get exposed, so researchers want to see if planned adjustments help. About 34 …

This study explores whether a culturally tailored Latin dance program can improve sleep quality for Hispanic cancer survivors. Researchers will enroll 40 adults who have finished primary cancer treatment and have trouble sleeping. Participants will either join dance classes or co…

This study looks at whether giving a numbing injection to the throat during vocal cord surgery can help reduce pain, coughing, and improve voice recovery afterward. About 28 adults with benign vocal cord growths will receive either the numbing medicine or a placebo (salt water) d…

This study is testing a new smartphone app that uses mindfulness techniques to help people with cancer quit smoking. About 50 adult cancer survivors who smoke at least one cigarette a day and want to quit in the next month will try the app. Researchers will measure how easy the a…

This study looks at whether a special therapy can help children aged 3 to 17 who have severe problem behaviors, like aggression or self-injury. The therapy involves practicing times when the child can have their way and times when they cannot, to see if this reduces the return of…

This study looks at whether a type of talk therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) can help older African Americans sleep better and think more clearly. About 20 people aged 60 and older with long-term insomnia will take part. They will either join 8 week…

This study aims to understand how genes influence the risk of kidney disease. Anyone 18 or older living in the US can join, even without a kidney disease diagnosis. Participation is online and involves completing health surveys and providing a saliva sample by mail. Participants …

This study tests a digital tool called mySmartSkin that helps melanoma survivors do thorough skin self-exams at home. About 385 people who had melanoma surgery in the past 3 months to 5 years will use the app. The goal is to see if the app helps them check all body parts and lead…

This study looks at how genes influence breast cancer risk. Anyone 18 or older living in the US can join, even if you don't have cancer. You fill out online surveys and mail in a saliva sample. Participants may get free genetic ancestry information.

This study is looking at the genetic makeup of tumors from 1,100 people with rare or hard-to-treat cancers. By finding specific gene changes, researchers hope to better understand these cancers and identify potential new treatment options. The goal is to improve diagnosis and car…

This study looks at how hormone receptor-positive/HER2-negative breast cancer uses energy (sugar). About 16 people with early-stage breast cancer will get a special glucose infusion before surgery. Researchers will then analyze tumor samples to understand the cancer's metabolism.…

This study is testing a training program called DECIDE for healthcare providers who care for pregnant and new mothers with mental health conditions. The training teaches providers how to communicate better and make shared decisions with their patients. Researchers will ask 35 pro…

This study looks at how a brain stimulation technique called TMS can change the way we process space and rewards while navigating in a virtual environment. Researchers will measure brain waves in 60 healthy adults to see if TMS can boost or reduce activity in a brain area linked …

This study looks at children aged 3 to 17 who have serious problem behaviors like aggression or self-injury. Researchers want to understand why some children's behavior gets worse at the very start of a common treatment called extinction. By observing 40 children, they hope to fi…

This study looks at whether educational events about clean beauty can help Black women in Newark, NJ make safer choices with hair products. Many products marketed to Black women contain chemicals that may affect hormones or increase cancer risk. Researchers will survey about 120 …

This study looks at how the choices we make affect what we remember. Researchers will record brain activity from 50 epilepsy patients while they perform decision-making and memory tasks. The goal is to understand the brain mechanisms linking decision-making and memory, which coul…

This study looks at how tiny particles in the blood, called extracellular vesicles, affect blood flow in people with type 2 diabetes. Researchers want to understand if exercise can change these particles and improve blood vessel health. About 60 adults with or without diabetes wi…

This study looks at how attention and specific thinking strategies influence decision-making and brain activity in people with schizophrenia or schizoaffective disorder compared to those without. Researchers will use brain scans and eye-tracking while participants play gambling-l…

This study trains high school students to encourage their adult family members to get screened for cancer. Researchers want to see if this youth-led approach increases screening rates and knowledge. About 84 teens and adults are taking part.

This study tests a culturally tailored coaching program to help Hispanic smokers and former smokers decide whether to get screened for lung cancer. About 91 participants will work with bilingual patient navigators who guide them through the decision process. The goal is to see if…

This study looks at how breathing in ozone, a common air pollutant, affects the cells in your lungs. Healthy adults will breathe filtered air and low-level ozone on separate days. After each session, they will cough up a sample to measure how active their immune cells are. The go…

This study aims to find the best location on the brain to apply magnetic stimulation (TMS) to increase reward-related brain activity in smokers. Researchers will test different targeting methods in 36 nicotine-dependent adults across three sessions. The goal is to see which targe…

This study tests whether playing a web-based game called the Breakfast Game can improve thinking skills in healthy adults aged 60-75. Participants will play the game for 10 sessions over a month and take thinking tests before, after, and three months later. The goal is to see if …

This study looks at whether a health coach can help people at high risk for lung cancer make better decisions about getting screened. About 594 current or former smokers aged 50-77 will either get coaching or usual care. The goal is to see if coaching leads to more informed choic…

This study looks at whether charcoal-filtered cigarettes change how people smoke and their exposure to harmful chemicals. About 252 adult smokers who smoke at least 5 cigarettes daily will take part. Over 5 weeks, they will smoke either charcoal-filtered or regular cigarettes, an…

This study aims to understand how genes influence the risk of developing pulmonary hypertension, a serious lung condition. Anyone 18 or older living in the US can join, even without a diagnosis. Participants complete online health surveys and provide a saliva sample by mail, and …

This pilot study is testing a nerve block injection in the jaw muscles of 20 healthy adults. Researchers will measure how bite force and muscle activity change after the injection, at 30 minutes, 2 hours, and 2 weeks. Participants will also share their experience. The goal is to …