PREGNANCY

This study tests the safety and immune response of the MVA-BN mpox vaccine in 359 pregnant and postpartum women in the Democratic Republic of the Congo. Some women receive the vaccine during pregnancy, others right after giving birth, and a small group gets it as an emergency sho…

This study looks at two different ways to prevent tuberculosis (TB) in pregnant women who also have HIV. About 252 pregnant women will take either a daily TB prevention pill for one month or a weekly pill for three months. The goal is to see if these treatments are safe and how t…

This study tests whether taking omega-3 fatty acid supplements can slow the rise of triglycerides (a type of blood fat) in pregnant women who have higher-than-normal levels. High triglycerides in pregnancy may increase the chance of having a large baby. The study involves 40 preg…

This study tests whether attending prenatal care in a group setting, rather than one-on-one visits, helps pregnant women with type 2 or gestational diabetes better control their blood sugar and manage weight after delivery. About 117 English-speaking women up to 34 weeks pregnant…

This study looks at whether delivering healthy meals to the homes of low-income Black pregnant women can improve their diet, help them gain the right amount of weight during pregnancy, and support better blood pressure. About 17 women with overweight or obesity are receiving meal…

This study tests a team-based care model for pregnant and postpartum women with opioid use disorder in low-resource clinics. About 1,350 participants will receive coordinated support to start and stay on medication, reduce overdose risk, and improve well-child visits. The goal is…

This study tests a mobile health program (i-PregMom app) to help pregnant women control their blood sugar and weight gain. About 160 first-time mothers will use the app from early pregnancy (10-14 weeks) to mid-pregnancy (24-28 weeks). The goal is to see if the app improves healt…

This study tests whether combining text message support for pregnant women who smoke with special training for their OB doctors can help them quit. About 840 women from Duke and Pitt will take part. All receive smoking cessation texts; some doctors get extra counseling training. …

This study tests whether having obstetric providers manage care for a full year after childbirth can improve blood pressure and blood sugar control in mothers with high blood pressure or diabetes. About 100 pregnant women with these conditions and Medicaid insurance will receive …

This study looks at whether testing pregnant women for malaria in the first trimester using a highly sensitive rapid test, and treating those who test positive, can prevent serious problems like low birth weight, preterm birth, stillbirth, or newborn death. Over 2,000 women in ea…

This pilot study is testing a lifestyle physical activity program to help pregnant women cut down on cannabis use. The study includes 50 pregnant women aged 18 and older who used cannabis at least once a week before pregnancy and want to stop. Participants will be guided to incre…

This study tests whether giving riboflavin (vitamin B2) alone or with folate can prevent high blood pressure in pregnant women who have a specific gene change (MTHFR TT genotype). About 2250 women in early pregnancy will be screened for the gene, and those with the variant will r…

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the number of live births in women under 37 who are having a type of IVF called ICSI. About 366 couples took part. The goal is to see if this simple change can improve…

This study tests whether listening to educational podcasts can reduce intense fear of childbirth in couples. About 50 pregnant women and their partners will be randomly assigned to receive podcast training or standard care. The goal is to lower anxiety, improve emotional well-bei…

This study looks at whether teaching ThetaHealing meditation to first-time pregnant women can help reduce their pain and fear during labor. Forty healthy women in their first pregnancy will learn the meditation method before birth and use it during labor. Researchers will also us…

This study tests a device called Emagina that uses a small balloon to train the pelvic floor muscles during pregnancy. The goal is to see if it makes the perineum more flexible and reduces tears or the need for stitches during childbirth. About 88 first-time mothers will either u…

This study looks at whether a special mindfulness class (Mindfulness-Based Childbirth and Parenting) can help pregnant women with high anxiety feel better. Sixty pregnant women will be randomly assigned to either the mindfulness class or a standard childbirth class. Researchers w…

This study looks at whether progressive muscle relaxation and finger grip exercises can lower stress, anxiety, and fatigue while improving sleep in pregnant women with preeclampsia. About 90 women will be split into three groups: one doing relaxation exercises, one doing finger g…

This pilot study tests whether giving calcium carbonate to pregnant women during labor induction can safely shorten the time needed and reduce the amount of oxytocin (a labor-inducing drug). Researchers also want to see if it lowers the chance of stalled labor and C-sections. The…

This study looks at whether a structured exercise program during the second and third trimester can improve fitness, blood pressure, and weight gain in first-time mothers, and also benefit the baby's health. Researchers will measure heart and lung fitness, blood markers, and newb…

This study tests whether using a virtual reality (VR) relaxation program can reduce nausea and vomiting, improve sleep quality, and increase comfort in pregnant women. About 90 women in early pregnancy (6-14 weeks) will either use VR relaxation or receive standard care. The goal …

This study looks at whether eating dates during the first three months of pregnancy can reduce vomiting from morning sickness and improve iron levels. About 40 pregnant women will either eat dates, take standard anti-nausea medication, or follow their usual diet. The goal is to f…

This study tested a 10-week mindful eating self-help program for pregnant women who binge eat. It aimed to see if the program was easy to use and helped improve eating habits and well-being. The study was withdrawn before enrolling any participants, so no results are available.

This study looks at health insurance records to check if taking prucalopride for constipation during pregnancy is safe for mothers and babies. Researchers will compare pregnant women who took prucalopride, those who took other constipation medicines, and those who took no prescri…

This study aims to understand how drugs like cocaine, alcohol, marijuana, and cigarettes taken during pregnancy affect the way mothers and babies bond. Researchers will look at the baby's brain and behavior shortly after birth. The study involves 150 mothers and their newborns.

This study follows about 728 pregnant women who took Wegovy for weight loss and compares them to similar pregnant women who did not take the drug. Researchers will track birth defects and other health outcomes in babies up to one year old. The goal is to better understand the saf…

This study tests a special education program for first-time mothers that combines hypnosis techniques with breastfeeding information. The goal is to see if it helps mothers feel more confident and motivated to breastfeed. About 80 healthy pregnant women will take part, and resear…

This study follows 9,000 pregnant women in Zambia from early pregnancy through one year after birth. Researchers collect medical information and biological samples to learn why some babies are born too early. The goal is to find new ways to prevent preterm birth and stillbirth.

This study looks at how a mother's stress and mental health may affect her body's ability to handle sugar during pregnancy, which is linked to gestational diabetes. Researchers will study 150 pregnant women to find patterns that could help identify those at risk earlier. The goal…

This study looks at health records of about 1,100 women who took Wegovy during pregnancy and compares them to those who did not. The goal is to see if the drug increases risks for birth defects or other problems in babies. Researchers will use insurance claims data to track outco…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study aims to understand how the body's response to insulin changes during pregnancy in people with type 1 diabetes. Researchers will analyze data from continuous glucose monitors and insulin pumps used by 100 participants from before pregnancy to six months after birth. The…

This study looks at whether giving fatty acid supplements to pregnant African American women living in low-income areas can lower their stress and improve their baby's growth and brain development. About 168 women will take part, and researchers will track stress levels and baby …

This study adapts an existing support program to help pregnant and postpartum women living with HIV in Ghana cope with stigma and stay healthy. Researchers will interview women and providers, then test the adapted program with 90 pregnant women to see if it reduces stigma and imp…

This study looks at sleep health in 50 pregnant women with low income. Researchers will use a home sleep test and a wrist monitor to measure sleep. They want to see how sleep relates to heart health and social factors. The goal is to create better sleep screening and treatments f…

This study looks at whether showing a short video to pregnant women at least 24 hours before a planned C-section helps them better understand the risks and benefits of anesthesia. Researchers will compare how well these women make informed decisions about their care versus those …

This study was designed to see if a special MRI technique could measure blood flow in the placenta during pregnancy. The goal was to compare placentas in pregnancies where the baby is growing poorly (IUGR) with healthy pregnancies. However, the study was withdrawn before any part…

This study gathered expert doctors to create a list of safe skin care practices for pregnant women. The goal was to help mothers keep their skin healthy without harming their baby. The experts agreed on which ingredients to use, like vitamin C and hyaluronic acid, and which to av…

This study looks at whether a simple urine pregnancy test taken 2 weeks after a medication abortion can reliably show the abortion is complete, instead of waiting the usual 4 weeks. About 400 people with very early pregnancies (up to 42 days) will take weekly tests and answer sym…

This study was designed to see if a device called ClearSight™ can accurately measure blood flow changes in pregnant women at term. Researchers planned to compare it with a standard ultrasound method during a leg-raising test. The goal was to help doctors give fluids more safely d…

This study looks at whether using virtual reality (VR) during a C-section can lower the risk of postpartum depression and anxiety. About 98 pregnant women will be split into a VR group and a control group. Researchers will measure mood changes and certain blood chemicals linked t…

This study looks at how making birth control more affordable affects women's choices and outcomes. Researchers are tracking about 5,000 women in Michigan to see if easier access to contraception changes things like pregnancy rates, education, jobs, and financial stability. The go…

This study aims to create clear, expert-backed recommendations for using vitamins, minerals, and other supplements during pregnancy. Currently, there is a lot of variation in how doctors prescribe these products. The study will involve 15 specialists who will answer questions in …

This study looks at whether a brief home visitation program for pregnant and new mothers can help them connect with community resources, feel more confident about their health, and lower their stress. Half of the 450 participants will receive free home visits from a non-nurse vis…

This study is creating a large collection of biological samples and health data from 3,000 people with gynecological disorders, infertility, or pregnancy-related conditions. The goal is to help researchers better understand these health issues, including their genetic causes. Par…

This study looks at how much of the drug sugammadex crosses the placenta from mother to baby. Researchers will use donated placentas in a lab model to measure drug levels. The goal is to understand possible risks to the fetus when the drug is given during pregnancy. Sixteen place…

This study looks at whether group nutrition classes help pregnant women gain weight within recommended ranges. About 216 women with uncomplicated pregnancies will either attend three weekly nutrition classes plus a cooking session, or receive standard care with a brochure. Resear…

This study was designed to test a program called PROMOTE, which trains healthcare providers to counsel pregnant patients about workplace accommodations and rights. Researchers planned to compare how often providers discussed work-related issues and whether patients experienced be…