INTRAHEPATIC CHOLANGIOCARCINOMA

This study is for people with a type of liver cancer called intrahepatic cholangiocarcinoma that cannot be removed with surgery but hasn't spread. Participants will receive chemotherapy first, and if their cancer stays stable or shrinks for at least 6 months, they may get a liver…

This study tests a new way to give radiation for liver cancer that uses real-time MRI to guide the beam and adjust the plan during a single treatment session. It aims to improve survival and reduce side effects compared to standard radiation. The trial is for adults with certain …

This study is for people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be removed by surgery. It compares two treatments delivered directly to the liver's blood supply—HAI-FUDR/DEX and SIRT—both given alongside standard chemotherapy. The goal is to shr…

This study tests whether a liver transplant after a special type of internal radiation (SIRT) and chemotherapy can help people with advanced bile duct cancer that cannot be removed by surgery. The goal is to see if this approach improves survival over 3 years. The study plans to …

This study looks at whether a chemotherapy pump placed in the liver's main blood vessel is safe and practical for people with colorectal cancer or bile duct cancer that has spread to the liver. About 80 participants will get the pump surgically implanted and then choose to have t…

This study compares standard chemotherapy (gemcitabine and oxaliplatin) alone versus the same drugs plus a liver-directed chemotherapy (HAI FUDR/dexamethasone) in people with bile duct cancer that has spread only to the liver and cannot be removed. The goal is to see if adding th…

This study tests a new combination of drugs for people with advanced intrahepatic cholangiocarcinoma, a type of liver cancer that cannot be removed by surgery. About 35 participants will receive an oral drug called chidamide along with standard chemotherapy and immunotherapy. The…

This study tests a combination of two drugs (pemigatinib and durvalumab) in people with advanced bile duct cancer that has a specific change in the FGFR-2 gene and has not responded to prior treatment. The goal is to see if this combination can shrink tumors or slow the cancer. A…

This study tests a new drug called ALE.P03 in adults with advanced cancers (cervical, lung, colorectal, bile duct, or bladder) that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to target a protein called Claudin-1 found on these tumor…

This early-stage study is testing the safety of a new method to deliver chemotherapy directly into the abdomen for patients with advanced bile duct or gallbladder cancer that has spread there. The method, called PIPAC, uses a special device to spray chemotherapy as a fine mist du…

This study aims to develop a blood test that uses tiny particles called exosomes and machine learning to help doctors accurately tell apart two common types of liver cancer—hepatocellular carcinoma and cholangiocarcinoma—before surgery. Researchers will collect blood samples from…

This study tests whether people with liver cancer can recover at home after a procedure that delivers chemotherapy directly to the tumor, instead of staying in the hospital. About 206 adults with liver cancer will be randomly assigned to either home or hospital recovery. Research…