CHILDREN

This study tests two types of mouthwash—one with good bacteria (probiotics) and one with a special ingredient (ethyl lauroyl arginate)—to see which better reduces cavity-causing germs, plaque buildup, and acidity in the mouths of Egyptian schoolchildren aged 6 to 12. About 66 hea…

This study tests whether a structured nutrition program can prevent malnutrition in children with solid tumors. About 400 children will receive either standard care or a team-based nutrition plan that includes special short-peptide supplements. The goal is to improve weight, heig…

This study looks at the long-term safety of adding finerenone to standard blood pressure medicines for children aged 1 to 18 with chronic kidney disease and protein in their urine. About 100 participants who were in a previous finerenone study will take the drug for up to 18 mont…

This study tests whether a new drug called Telpegfilgrastim, given as a single shot, works better than the standard daily Filgrastim to prevent low white blood cell counts (neutropenia) in children and young adults aged 6-24 with solid tumors. About 132 participants will receive …

This study tests a combination of drugs (liposomal mitoxantrone, capecitabine, and anlotinib) in children, adolescents, and young adults aged 6 to 24 whose solid tumors have returned or not responded to treatment. The goal is to see if this combo can shrink tumors or stop them fr…

This early-stage trial tests whether blinatumomab, a drug used for certain blood cancers, can safely control severe lupus in children. Six participants will receive two short courses of the drug and be monitored for a year. The goal is to see if it reduces disease activity and si…

This study tests whether giving ozone gas through the rectum can help protect the brain in children who have suffered a brain injury from events like trauma, infection, or lack of oxygen. About 120 children from 1 month to 18 years old will receive the treatment while in intensiv…

This study looks at whether levothyroxine, a thyroid hormone medication, can improve heart function in children with subclinical hypothyroidism (a mild form of underactive thyroid). Researchers will measure heart pumping ability in 40 children aged 4 to 15 before and after treatm…

This study tests whether giving tuberculosis (TB) preventive medicine right away to children and teens who live with a TB patient can stop them from getting infected. About 647 kids aged 5 to 17 will be split into two groups: one gets the medicine immediately, the other gets stan…

This study tests whether a taurolidine lock solution, placed inside the catheter after each use, can prevent infections better than a standard saline lock. The trial involves 148 children and young adults with cancer who need a central catheter. Participants are randomly assigned…

This study tests a program designed to prevent childhood obesity in vulnerable families with children aged 6 months to 3 years. About 526 families with at least one parent who has overweight or obesity will take part. The program includes group sessions on healthy eating, physica…

This study tests whether a high-flow nasal cannula (HFNC) can prevent dangerously low oxygen levels in children during the critical moment when anesthesia stops their breathing before a breathing tube is placed. Researchers will enroll 48 healthy children aged 2-10 and measure ho…

This study looks at whether watching a short educational cartoon about the operating room can help lower anxiety in children aged 7 to 12 who are about to have surgery. About 159 kids will be split into three groups: one watches the educational cartoon, one watches a fun cartoon,…

This study tests whether injecting botulinum toxin-A (like Botox) into the bladder can help children under 18 who have trouble urinating or wet the bed at night and haven't improved with standard treatments. The goal is to see if it improves symptoms and to check for side effects…

This study tests a nasal spray combining two medicines (dexmedetomidine and esketamine) to help children aged 1-6 relax before surgery. The goal is to find the best dose that makes kids calm enough for a smooth start to anesthesia. 80 children will participate, and researchers wi…

This study looks at two hands-on treatments—scooping mobilization and dynamic cupping—to see which works better for children ages 6 to 13 with stiff elbows after a broken bone. Each child gets one of the therapies plus electrical stimulation for 4 weeks. The goal is to improve el…

This study tests whether a long-acting opioid (methadone) works better than short-acting opioids (fentanyl/hydromorphone) for pain control after cleft palate repair in infants and young children aged 6 months to 4 years. The goal is to reduce the total amount of opioids needed an…

This study compares two types of exercise—cognitive-motor training (combining thinking and movement) and Pilates—to see which better improves balance and stability in children with Down syndrome. Thirty-two children aged 8 to 13 will participate in 8 weeks of supervised sessions.…

This study tests whether high-dose omega-3 supplements can reduce ADHD symptoms like inattention and impulsivity in children and teens who are deficient in omega-3. About 100 participants will take omega-3 or a placebo for 12 weeks. The goal is to see if this natural supplement c…

This study tests whether a nasal spray containing two medicines (dexmedetomidine and esketamine) can safely reduce pain in children aged 3-7 after tonsil and adenoid surgery. About 160 children will receive either the spray or a placebo, and their pain levels will be tracked for …

This study tests whether giving children oral melatonin or a nebulized drug called dexmedetomidine before tonsil surgery can reduce confusion and agitation when they wake up. It involves 96 children aged 3 to 7. The goal is to find a better way to keep kids calm and comfortable a…

This study compares standard bladder training with and without biofeedback for children who have trouble emptying their bladder properly. About 124 children under 18 with dysfunctional voiding will participate. The goal is to see if adding biofeedback—a technique that uses sensor…

This study tests a drug called romiplostim N01 in children and young adults (ages 6-24) with cancer who have low platelets from chemotherapy. The goal is to see if weekly injections can safely raise platelet counts and reduce bleeding risk. About 50 participants will receive the …

This study tests whether adding acupuncture to herbal treatment can improve ADHD symptoms in children aged 6 to 12. Researchers will measure attention, behavior, and quality of life using parent questionnaires and interviews. The goal is to see if acupuncture offers extra benefit…

This study tests whether game-like rewards (points, streaks, and levels) help children aged 9-12 stick to healthy behaviors. About 160 kids will be split into four groups, each with a different reward system. The goal is to see which approach best encourages long-term participati…

This study looks at how physical activity affects thinking and learning in children born with heart problems. Researchers will compare these children to others having different surgeries or healthy peers. They will also test if a structured exercise program after heart surgery im…

This study uses safe brain imaging techniques (NIRS and EEG) to see which parts of the brain are active during movement in people with cerebral palsy and healthy volunteers. Researchers hope to learn how the brain controls muscles differently in cerebral palsy, which could lead t…

This study looks at how drinking milk or eating yogurt affects thinking and memory in healthy children aged 9 to 14. Researchers will test kids' attention, memory, and mood after they consume different dairy products. The goal is to understand how dairy might help the brain throu…

This study checks if a new device called the K-Pull dynamometer can reliably measure leg strength in healthy children aged 5 to 16. Researchers will compare it to a standard machine to see if it works well. The goal is to provide a simple, accurate way to assess leg function in k…

This study looks at the best way to teach CPR to kids in primary school. About 550 healthy children will either get a 2-hour hands-on session with a nurse and mannequin, or a short video and puzzle activity. The goal is to see which method helps them learn CPR better, so more peo…

This study tests a personalized breathing maneuver in children on ventilators—either after heart surgery or with severe lung failure. The goal is to see if adjusting the breathing machine settings can improve heart and lung function, reduce time on the ventilator, and lower the n…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…

This study looks at 300 children under age 3 who were conceived using advanced fertility methods like ICSI and frozen embryo transfer. Researchers will measure their growth, development, and reproductive health to see if these methods have any effects. The goal is to learn more, …