CHILDREN

This study tests the long-term safety of finerenone, a drug that helps control a key system involved in kidney damage, in children aged 1 to 18 with chronic kidney disease and proteinuria. All 100 participants will take finerenone alongside their usual ACE inhibitor or ARB medica…

This study tests whether adding calcitriol to vitamin D2 helps children with cholestatic liver disease correct their vitamin D deficiency faster than vitamin D2 alone. Cholestasis makes it hard for the body to absorb vitamin D. The trial will enroll 54 children and track vitamin …

This study tests a combination of drugs (liposomal mitoxantrone, capecitabine, and anlotinib) in children, adolescents, and young adults whose solid tumors have returned or not responded to previous treatments. The goal is to see if this regimen can shrink tumors or stop them fro…

This study tests a drug called romiplostim N01 in children, adolescents, and young adults (ages 6-24) with cancer who develop low platelet counts from chemotherapy. The drug is given as a weekly shot to help the body produce more platelets. The goal is to see if it can safely and…

This study tests whether a single injection of Telpegfilgrastim works better than daily Filgrastim shots to prevent fever and low white blood cells in children and young adults (ages 6-24) with solid tumors receiving strong chemotherapy. About 132 participants will receive either…

This study tests whether a structured nutrition program can prevent malnutrition in children with solid tumors. About 400 children will receive a team-based nutrition plan including special diets. The goal is to improve weight, height, and overall health during treatment.

This study looks at whether treating children with a mild form of underactive thyroid (subclinical hypothyroidism) using a medication called levothyroxine can improve how well their hearts pump blood. The researchers will measure heart function in 40 children aged 4 to 15 before …

This study tests two mouthwashes—one with probiotics (good bacteria) and one with ethyl lauroyl arginate—to see which better reduces cavity-causing bacteria, plaque, and acidity in the mouths of Egyptian children aged 6 to 12. Researchers will measure bacteria levels and plaque b…

This early trial tests if blinatumomab, a drug used for certain blood cancers, can help children with severe lupus that hasn't improved with other treatments. Six children will receive two short courses of the drug and be monitored for a year. The main goals are to check safety a…

This study tests whether giving ozone gas through the rectum can help protect the brain in children who have suffered a brain injury. 120 children aged 1 month to 18 years will either receive up to 80 rectal ozone sessions plus standard rehab, or rehab alone. The main goal is to …

This study tests a 9-session group program for parents of children aged 6 months to 3 years, focusing on healthy eating, physical activity, and sleep. About 526 families from Spain will take part, with half receiving the program and half getting usual care. The goal is to see if …

This study tests whether a special solution (taurolidine) placed inside the catheter can prevent infections better than the standard saltwater solution. About 148 children with cancer who need a central catheter will take part. The goal is to see if the taurolidine lock reduces t…

This study tests whether giving tuberculosis (TB) prevention drugs immediately to children and teens who live with someone with active TB can stop them from getting infected. About 647 participants aged 5 to 17 will be randomly assigned to receive either immediate treatment or st…

This study tests whether a high-flow nasal cannula (HFNC) can prevent dangerously low oxygen levels in children aged 2-10 during anesthesia before intubation. Researchers will compare safe apnea time—how long oxygen stays above 95%—in 48 healthy children. If effective, HFNC could…

This study looks at whether acupuncture can improve symptoms of ADHD in children ages 6 to 12. Researchers will give some kids acupuncture plus herbal medicine, and others just herbs, then compare results using parent surveys and interviews. The goal is to see if adding acupunctu…

This study looks at whether watching a cartoon or playing a mobile game for 10 minutes before surgery can lower anxiety and fear in children aged 7 to 12 who are hospitalized for appendicitis. About 69 children will be split into three groups: one watches a cartoon, one plays a m…

This study tests whether a single dose of methadone, a long-acting opioid, can control pain better than standard short-acting opioids (like fentanyl) in infants and young children after cleft palate repair. About 60 children aged 6 months to 4 years will participate. The goal is …

This study tests whether injecting botulinum toxin-A (like Botox) into the bladder can help children with certain bladder problems that haven't improved with standard treatments. It includes children under 18 with either dysfunctional voiding (trouble peeing normally) or nighttim…

This study tests whether a nose spray containing two drugs, dexmedetomidine and esketamine, can reduce pain after tonsil and adenoid surgery in children aged 3 to 7. About 160 kids will receive either the drug combo or a placebo spray right after anesthesia. Researchers will trac…

This study tests whether watching a short educational cartoon about surgery can lower anxiety in children aged 7 to 12 before an elective procedure. About 159 children will be randomly assigned to watch the educational cartoon, a fun cartoon they already like, or receive standard…

This study tests two hands-on therapies—scooping mobilization and dynamic cupping—to see which better improves elbow movement and function in children aged 6-13 with stiffness after a fracture. Twenty-eight children will receive one of the treatments combined with electrotherapy …

This study looks at whether adding biofeedback (a therapy that uses sensors to help children learn to control their pelvic muscles) to standard bladder training helps children with dysfunctional voiding (trouble peeing normally). About 124 children under 18 will be randomly assig…

This study compares two types of exercise—cognitive-motor training (combining thinking tasks with movement) and Pilates—to see which better improves balance in children with Down syndrome. Thirty-two children aged 8 to 13 will be randomly assigned to one of the two groups and tra…

This study is testing whether high-dose omega-3 fatty acids can reduce ADHD symptoms like inattention and impulsivity in children and adolescents who are deficient in omega-3. About 100 participants will take omega-3 supplements or a placebo for 12 weeks. The goal is to see if th…

This study tests whether giving children oral melatonin or a nebulized drug called dexmedetomidine before surgery can reduce confusion and agitation when they wake up after adenotonsillectomy. About 96 children aged 3 to 7 will be randomly assigned to one of three groups: melaton…

This study tests a nasal spray combining two medicines (dexmedetomidine and esketamine) to help children aged 1-6 relax before surgery. The goal is to find the best dose that makes kids calm enough for a smooth start to anesthesia. About 80 children will take part to see how well…

This study uses safe brain imaging techniques (NIRS and EEG) to see how the brain controls movement in people with and without cerebral palsy. Researchers will compare brain activity patterns and test whether biofeedback training can help people with cerebral palsy improve their …

This study tests a new way to treat the surface of zirconia dental bridges before bonding them to teeth. Researchers compare a nano-structured alumina coating to standard sandblasting in 80 people missing a front tooth. The goal is to see which method helps the bridge stay in pla…

This study tests whether using game-like features—such as earning points, maintaining streaks, and leveling up—can help children aged 9 to 12 stick to completing health-related questionnaires. About 160 children will use a mobile app with different reward schemes, including finan…

This study tests whether a personalized lung volume optimization maneuver can improve heart and lung function in children on ventilators. It includes two groups: children recovering from heart surgery and those with severe respiratory failure. Researchers will adjust ventilator p…

This study looks at whether a structured physical activity program can improve thinking and learning in children who had heart surgery. Researchers will compare these children to those having other surgeries and healthy kids. The goal is to see if exercise helps with memory, atte…

This study checks if a new device called the K-Pull dynamometer can reliably measure leg muscle strength in healthy children aged 5 to 16. Researchers will compare its results to a standard machine to see how accurate it is. The goal is to provide a simple, portable way to assess…

This study looks at the long-term health of children (16 years and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's transplant or medications.…

This study tests two methods of teaching CPR to 550 primary school children in Spain. One group gets a 2-hour hands-on session with a nurse and mannequins; the other watches a short video and does a puzzle. Researchers will measure which group learns CPR better, aiming to improve…

This study follows 300 children under age 3 who were conceived through IVF or ICSI. Researchers will measure their growth, brain development, and reproductive health to see if these conception methods have any effects. No new treatments are being tested—the goal is simply to gath…

This study looks at how drinking milk or eating yogurt affects thinking and memory in healthy children ages 9 to 14. Researchers will give kids different dairy snacks and test their attention, memory, and mood over two hours. The goal is to understand if dairy products can help k…