CHILDREN

This trial tests whether a WhatsApp-based program called SmileConnect can help parents improve their children's oral health. The program sends educational messages, reminders, videos, and fun brushing activities to parents of primary school children aged 5-12. Researchers will co…

This study follows children aged 9–12 with an underdeveloped upper jaw (maxillary retrognathism) causing a reverse bite. They receive standard interceptive orthodontic treatments, such as facemasks or other appliances, to guide jaw growth. Researchers track changes in jaw positio…

This study tests whether giving two antiviral drugs—entecavir followed by pegylated interferon—can help children aged 3 to 6 with chronic hepatitis B achieve a functional cure (clearing the virus from the blood). About 80 children will be randomly assigned to receive either entec…

This study tests whether adding pegylated interferon to entecavir helps young children (ages 3-6) with chronic hepatitis B achieve a functional cure, meaning the virus becomes undetectable. Sixty children will receive either entecavir alone or entecavir followed by the combinatio…

This study tests a special optical film called S.T.O.P®KIT that attaches to eyeglasses. The goal is to slow down the growth of the eye in children aged 6 to 10 with mild farsightedness, which may help prevent nearsightedness later. 180 children will be split into two groups: one …

This trial tests whether a combination of esketamine and remimazolam can reduce breathing problems in children aged 6 to 12 during gastroscopy, compared to the traditional propofol-based sedation. Children have smaller airways and lower oxygen reserves, making them more prone to …

Dental injections are a major source of fear for children, but numbing gels and sprays may help. This study compares four common topical anesthetics—benzocaine spray, benzocaine gel, lidocaine spray, and lidocaine gel—to see which one best reduces pain and anxiety in 160 children…

This study tests whether an activity book called 'Think-Find-Solve' can improve insulin self-management in children aged 8-12 with type 1 diabetes. Forty children and their parents will take part, with one group using the book for three months. The goal is to see if the book help…

This study tests whether a gentle yoga program done at the bedside can help children start moving earlier after surgery. Early movement can speed recovery, reduce pain, and lower the risk of complications like pneumonia or blood clots. The yoga includes breathing exercises and si…

This study tests whether adding exercise sessions and asthma education to usual care helps children aged 10-17 manage their asthma better. 60 participants will be randomly placed into one of three groups: usual care only, education only, or exercise plus education. The goal is to…

This study tests whether a 10-week camp program can help children and teens (ages 7-14) reduce binge eating. Some parents will also receive special training to see if it adds extra benefit. Researchers will follow participants for up to 5 years to track lasting effects.

This study looks at whether a fast, bedside test (SPOTFIRE) can help doctors better treat children with respiratory infections in the emergency department. About 720 children aged 2 months to 18 years will be randomly assigned to either get the rapid test or standard care. The go…

This study tests whether short, teacher-led activity breaks during regular school hours can improve children's enjoyment of physical activity and overall health. About 810 primary school children will take part, with some classes doing 5-minute active breaks each hour for 12 week…

This small study will test whether a type of therapy called Compassion Focused Therapy, combined with Loving Kindness Meditation, can help children aged 12-17 with epilepsy who feel anxious, stressed, or ashamed about their condition. Participants will attend three online therapy…

This study looks at whether children with ADHD and their parents will actually use a digital app called LUSHA for three months. The app is designed as a game to motivate behavior change and improve parent-child interaction. Researchers will track how often families use the app an…

This study tests whether letting children watch cartoons or giving them a gentle foot massage before surgery can reduce their nausea, pain, and anxiety. About 105 children aged 4 to 6 will be assigned to one of three groups: watching a cartoon, receiving reflexology, or standard …

This study looks at whether an 8-week CrossFit program can make kids aged 7 to 11 stronger, fitter, and happier. Thirty children will be split into two groups: one does CrossFit twice a week, the other continues their normal routine. Researchers will measure physical changes like…

This study looks at whether a special breathing maneuver during heart surgery can improve heart and lung function in children with congenital heart disease. About 80 children will be randomly assigned to receive either the maneuver or standard care. The goal is to see if this app…

This study follows 93 children aged 5-18 with brain tumors who are receiving radiation therapy. Researchers will track their nutrition and quality of life over time to see how they are connected. The goal is to create a nutrition plan and early warning system to help these childr…

This study will track 200 children admitted to the pediatric intensive care unit (PICU) to see how imbalances in minerals like sodium, potassium, and calcium affect their outcomes. Researchers aim to find which imbalances are linked to higher death rates and identify factors that…