CHILDREN

This study tests the safety and immune response of the MVA-BN mpox vaccine in 344 infants and children aged 4 to 24 months in the Democratic Republic of the Congo. Half of the children receive a full dose and half receive a half dose, both given as two shots 28 days apart. The go…

This study tests whether chemotherapy followed by local treatments can control retinoblastoma (an eye cancer in children) and avoid removing the eye or using radiation. About 133 children with different stages of the disease will receive tailored drug regimens. The main goal is t…

This study focuses on children aged 7 to 11 who are overweight and at risk for MASLD, a common liver condition. Researchers are testing a simple waist measurement (waist-to-height ratio) as a screening tool and will evaluate a lifestyle program involving school, clinic, family, a…

This study tests a new way to manage blood flow and oxygen in children after heart surgery. The goal is to prevent serious problems like low blood pressure and cardiac arrest by focusing on oxygen use in the body during the critical first 8 hours after surgery. About 300 children…

This study tests the safety and benefits of hydroxyurea, a medicine that helps control sickle cell disease, in children aged 3 to 10 in Africa. The goal is to make this treatment more widely available, especially for kids diagnosed early through newborn screening. The trial invol…

This study looks at children with congenital heart disease who take the blood thinner rivaroxaban after a Fontan procedure. The goal is to see how often serious or minor bleeding happens in real-world use. Researchers will collect data from medical records of 61 children for up t…

This study tests a program to help preschool children ages 3 to 6 in Suzhou, China, maintain a healthy weight. About 1,486 children will take part. The program includes healthy eating, physical activity, and education for families and teachers. Researchers will measure changes in…

This study tests whether a low-cost, colorful walkway (like a game mat) can help children aged 4-10 feel less pain and fear when they first get up after abdominal surgery. The walkway is meant to distract kids and make moving feel more like play. Researchers will measure pain, fe…

This study is testing a new way of running a diabetes clinic for children under 10. The clinic uses play, healthy lifestyle coaching, and parent support groups to help families manage diabetes with less stress. Researchers will measure if this approach improves quality of life fo…

This study tests a new exercise method called Dynamic Neuromuscular Stabilization training combined with ultrasound-guided pelvic floor exercises in children aged 6-14 who have trouble emptying their bladder. The goal is to see if this approach reduces leftover urine after going …

This study looks at whether using a palm stimulator or a stress ball can reduce pain, fear, and distress in children aged 6 to 12 during a respiratory panel collection (a nose or throat swab). About 35 hospitalized children will be randomly assigned to use one of these tools or r…

This study looks at how different types of shoes affect brain activity in 37 children aged 6-7. Kids walked while wearing no shoes, minimalist shoes, or regular shoes, and their brain waves were recorded with a special headset. The goal is to understand how footwear might influen…

This study looks at community programs in Rotterdam that help overweight children aged 4 to 12 and their families adopt healthier habits. About 1,000 children will take part in activities focused on diet, exercise, and motor skills. Researchers will measure changes in quality of …

This study looks at why parents of children aged 0-48 months are hesitant about vaccines. Researchers will use machine learning to find patterns and predict which parents might refuse vaccines. The goal is to help public health officials create better strategies to address concer…

This study looked at whether adding special movement-and-thinking games to regular gym class helps preschool children think faster and balance better. Fifty typically developing kids took part; half did the extra activities twice a week for 8 weeks, while the other half only had …

This study planned to test if using ultrasound and oxygen sensors during heart surgery could help doctors predict kidney injury in children. The goal was to find a faster way to spot kidney problems right in the operating room. However, the study was withdrawn before any patients…

This study looks at children diagnosed with autoimmune hyperthyroidism before age 6, tracking their symptoms, lab results, and growth over time. Researchers will compare these young patients with older children who have the same condition. The goal is to better understand how the…

This study looks at whether a child's body position (sitting vs lying down) changes the results of a test that measures pressure in the rectum and anal canal. Researchers will compare 60 children with constipation and 60 without, all aged 5 to 18. The goal is to find the best pos…

This study looks at whether a team-based plan can help doctors and staff better screen children for depression and connect them to mental health services. About 40 healthcare workers at a children's hospital will use a team charter to clarify roles and improve coordination. The g…

This study looks at how virtual reality (VR) affects the brain when children feel pain. Twenty healthy kids aged 6-17 will wear a blood pressure cuff to create mild pain and a brain scanner to measure brain activity while using VR games, watching a VR video, or playing an iPad ga…

This study looks at how secondhand smoke affects the gums of 146 healthy children. Researchers measure a protein linked to inflammation (S100A8/A9) and a nicotine byproduct (cotinine) in saliva. The goal is to understand early gum changes from smoke exposure, not to test a treatm…