CHILDREN

This Phase 3 study is testing the MVA-BN mpox vaccine in 344 infants and children aged 4 to 24 months in the Democratic Republic of the Congo, a region heavily affected by mpox. Researchers are comparing a standard dose to a half-dose to see if the lower dose is still effective a…

This study looks at children with congenital heart disease who take the blood thinner rivaroxaban after a Fontan procedure. The goal is to see how often serious or minor bleeding happens. Researchers will collect data from regular doctor visits for up to 2 years. No extra tests o…

This trial tests the drug hydroxyurea in 811 children with sickle cell anemia across Africa. The goal is to see if it is safe and effective, and to make it more available. Children take daily doses adjusted for their weight, and doctors monitor blood counts and fetal hemoglobin l…

This study tests a new way to manage blood flow and oxygen in children right after heart surgery. The goal is to help their bodies use oxygen better during the critical first 8 hours, which may prevent dangerous drops in blood pressure or heart function. About 300 children weighi…

This study evaluates 12 different healthy lifestyle programs for children aged 4 to 12 who are overweight. About 1,000 kids and their parents will take part in activities like sports, nutrition advice, and behavior coaching. Researchers will measure changes in quality of life, BM…

This study focuses on children aged 7 to 11 with a high waist-to-height ratio, a sign of possible fatty liver disease (MASLD). Researchers will test a simple screening method and a lifestyle program involving school, clinic, family, and community support. The goal is to improve e…

This phase 2 trial tests different chemotherapy regimens in 133 children with retinoblastoma, a rare eye cancer. The goal is to shrink tumors and avoid removing the eye or using radiation. Treatments include intravenous and intra-arterial chemotherapy, sometimes combined with las…

This study tests a program for children ages 3 to 6 that includes monthly health lessons and extra physical activity at school. The goal is to see if these activities help children maintain a healthy weight. About 1,500 children in Suzhou, China, are taking part.

This study tests whether simple distraction tools—a ShotBlocker device and a finger puppet—can reduce pain and fear in children aged 5 to 10 during blood draws. About 90 children will be randomly assigned to use one of these tools or receive standard care. The goal is to see if t…

This study tests whether placing a colorful, washable walkway mat in front of children's beds can reduce pain and fear and help them start moving sooner after abdominal surgery. About 74 children aged 4–10 will be involved. The mat is designed to distract and encourage kids to wa…

This study tests a new rehabilitation approach for children aged 6-14 with dysfunctional voiding, a condition where the bladder doesn't empty properly. The researchers compare standard pelvic floor muscle training with ultrasound guidance to a newer method that adds dynamic neuro…

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, nutrition advice, mental health support, and parent groups to help families feel calmer and more in control. About 100 children and their families will take part to see if this approac…

This study tests whether giving children a palm stimulator or a stress ball to squeeze during a respiratory swab can reduce their pain, fear, and distress. About 35 children aged 6 to 12 will be randomly assigned to use one of these tools or receive standard care. Researchers wil…

This study aims to understand why some parents of children aged 0-4 years are hesitant about vaccines. Researchers will use machine learning to analyze survey responses from 600 parents in Turkey. The goal is to build a model that can predict vaccine refusal, helping public healt…

This study examines autoimmune hyperthyroidism in children diagnosed before age 6, focusing on their symptoms, growth, and response to treatment. Researchers will compare these young children with older children who have the same condition. The goal is to identify patterns that c…

This study will use brain imaging to understand how virtual reality (VR) helps children manage pain. Twenty healthy kids aged 6-17 will wear a blood pressure cuff to create mild pain while playing VR games, watching a passive VR video, or using an iPad. Researchers will measure b…

This study was designed to see if doctors could predict kidney damage in children after heart surgery by using an ultrasound probe in the esophagus and a light-based oxygen sensor on the skin. The goal was to catch kidney problems early. However, the study was withdrawn before an…

This study looked at whether adding special movement-and-thinking games to regular gym class helps preschool children think faster and balance better. Fifty typically developing kids took part; half did the extra activities twice a week for 8 weeks, while the other half only had …

This study looks at how secondhand smoke impacts the gum health of 146 children. Researchers will measure specific proteins in saliva that signal inflammation, along with cotinine, a marker of smoke exposure. The goal is to better understand the early effects of passive smoking o…

This study tests whether a team charter—a simple written agreement that clarifies roles and coordination—can help doctors and staff screen children for depression more consistently and connect them to mental health services faster. Forty healthcare providers at a children's hospi…

This study looks at whether a child's body position (sitting vs. lying down) changes the results of a test that measures anal and rectal pressures. Researchers will compare these positions in 120 children aged 5 to 18, some with constipation and some without. The goal is to find …

This study looks at how different types of footwear affect brain activity in 37 children aged 6-7 years. Each child walks while wearing no shoes, minimalist shoes, and regular structured shoes, and their brain waves are recorded with a wireless EEG cap. The goal is to see if shoe…